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Adult central nervous system embryonal carcinoma

MedGen UID:
234580
•Concept ID:
C1370503
•
Neoplastic Process
Synonyms: Adult Central Nervous System Embryonal Carcinoma; adult central nervous system embryonal carcinoma; Adult CNS Embryonal Carcinoma; adult CNS embryonal carcinoma; adult embryonal carcinoma of the central nervous system; Central nervous system embryonal carcinoma; Embryonal Carcinoma of Adult Central Nervous System; embryonal carcinoma of adult central nervous system; Embryonal Carcinoma of Adult CNS; embryonal carcinoma of adult CNS; Embryonal Carcinoma of the Adult Central Nervous System; embryonal carcinoma of the adult central nervous system; Embryonal Carcinoma of the Adult CNS; embryonal carcinoma of the adult CNS; embryonal carcinoma of the central nervous system of adults
 
Monarch Initiative: MONDO:0004155

Definition

A embryonal carcinoma of the central nervous system that occurs in an adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult central nervous system embryonal carcinoma

Professional guidelines

PubMed

Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Germ cell tumours of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes.
Sawamura Y, Ikeda J, Shirato H, Tada M, Abe H
Eur J Cancer 1998 Jan;34(1):104-10. doi: 10.1016/s0959-8049(97)10045-4. PMID: 9624246
Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies.
Daugaard G, Rørth M, von der Maase H, Skakkebaek NE
Ann Oncol 1992 Apr;3(4):283-9. doi: 10.1093/oxfordjournals.annonc.a058180. PMID: 1327076

Recent clinical studies

Etiology

Extragonadal Germ Cell Tumors: A Single Institution Experience with Clinicopathological Correlation.
Sekar MD, Pradeep I, Srinivas BH, Kayal S
Int J Surg Pathol 2024 Aug;32(5):865-874. Epub 2023 Oct 19 doi: 10.1177/10668969231201413. PMID: 37853749
Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Molecular diagnostics in embryonal brain tumors.
Eberhart CG
Brain Pathol 2011 Jan;21(1):96-104. doi: 10.1111/j.1750-3639.2010.00455.x. PMID: 21129063Free PMC Article
Testicular embryonal cell carcinoma metastasizing to the site of a previously excised cerebellar haemangioblastoma.
Chacko AG, Rajshekhar V, Chacko G
Br J Neurosurg 1996 Apr;10(2):197-200. doi: 10.1080/02688699650040377. PMID: 8861313

Diagnosis

Diseases Predisposing to Adrenocortical Malignancy (Li-Fraumeni Syndrome, Beckwith-Wiedemann Syndrome, and Carney Complex).
Jouinot A, Bertherat J
Exp Suppl 2019;111:149-169. doi: 10.1007/978-3-030-25905-1_9. PMID: 31588532
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Molecular diagnostics in embryonal brain tumors.
Eberhart CG
Brain Pathol 2011 Jan;21(1):96-104. doi: 10.1111/j.1750-3639.2010.00455.x. PMID: 21129063Free PMC Article
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Neuroendoscopic management of pineal region tumours.
Ferrer E, Santamarta D, Garcia-Fructuoso G, Caral L, Rumià J
Acta Neurochir (Wien) 1997;139(1):12-20; discussion 20-1. doi: 10.1007/BF01850862. PMID: 9059706

Therapy

Clonal evolution as pathogenetic mechanism in relapse of primary CNS lymphoma.
Pels H, Montesinos-Rongen M, Schaller C, Van Roost D, Schlegel U, Wiestler OD, Deckert M
Neurology 2004 Jul 13;63(1):167-9. doi: 10.1212/01.wnl.0000132649.24618.8a. PMID: 15249632
Recurrent intracranial germinoma outside the initial radiation field with progressive malignant transformation.
Kon H, Kumabe T, Jokura H, Shirane R
Acta Neurochir (Wien) 2002 Jun;144(6):611-6. doi: 10.1007/s00701-002-0951-4. PMID: 12111494
Isolated central nervous system relapse of non-seminomatous germ cell tumour of the testis. A case report and review of the literature.
Cohn DA, Stuart-Harris R
Oncology 2001;61(3):184-8. doi: 10.1159/000055372. PMID: 11574772
Therapeutic strategies and surgical results for pineal region tumours.
Tamaki N, Yin D
J Clin Neurosci 2000 Mar;7(2):125-8. doi: 10.1054/jocn.1999.0164. PMID: 10844797
Germ cell tumours of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes.
Sawamura Y, Ikeda J, Shirato H, Tada M, Abe H
Eur J Cancer 1998 Jan;34(1):104-10. doi: 10.1016/s0959-8049(97)10045-4. PMID: 9624246

Prognosis

Co-fractionation-mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain.
Zilocchi M, Rahmatbakhsh M, Moutaoufik MT, Broderick K, Gagarinova A, Jessulat M, Phanse S, Aoki H, Aly KA, Babu M
Nat Protoc 2023 Dec;18(12):3918-3973. Epub 2023 Nov 20 doi: 10.1038/s41596-023-00901-z. PMID: 37985878
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes.
Matsumoto L, Yamamoto T, Higashihara M, Sugimoto I, Kowa H, Shibahara J, Nakamura K, Shimizu J, Ugawa Y, Goto J, Dalmau J, Tsuji S
Mov Disord 2007 Apr 15;22(5):728-31. doi: 10.1002/mds.21314. PMID: 17269131Free PMC Article
Testicular embryonal cell carcinoma metastasizing to the site of a previously excised cerebellar haemangioblastoma.
Chacko AG, Rajshekhar V, Chacko G
Br J Neurosurg 1996 Apr;10(2):197-200. doi: 10.1080/02688699650040377. PMID: 8861313
Intracardiac mass as the initial manifestation of metastatic germ cell tumor.
Stein M, Reisner S, Lachter J, Haim N
Int J Cardiol 1994 Jul;45(3):230-2. doi: 10.1016/0167-5273(94)90170-8. PMID: 7960269

Clinical prediction guides

Extragonadal Germ Cell Tumors: A Single Institution Experience with Clinicopathological Correlation.
Sekar MD, Pradeep I, Srinivas BH, Kayal S
Int J Surg Pathol 2024 Aug;32(5):865-874. Epub 2023 Oct 19 doi: 10.1177/10668969231201413. PMID: 37853749
Co-fractionation-mass spectrometry to characterize native mitochondrial protein assemblies in mammalian neurons and brain.
Zilocchi M, Rahmatbakhsh M, Moutaoufik MT, Broderick K, Gagarinova A, Jessulat M, Phanse S, Aoki H, Aly KA, Babu M
Nat Protoc 2023 Dec;18(12):3918-3973. Epub 2023 Nov 20 doi: 10.1038/s41596-023-00901-z. PMID: 37985878
12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience.
Gao Y, Jiang J, Liu Q
Int J Clin Exp Pathol 2014;7(10):6965-72. Epub 2014 Sep 15 PMID: 25400782Free PMC Article
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184

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