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Central nervous system endodermal sinus tumor

MedGen UID:
234604
•Concept ID:
C1377613
•
Neoplastic Process
Synonyms: central nervous system endodermal sinus tumor; Childhood Central Nervous System Endodermal Sinus Neoplasm; childhood central nervous system endodermal sinus neoplasm; Childhood Central Nervous System Endodermal Sinus Tumor; childhood central nervous system endodermal sinus tumor; childhood central nervous system endodermal sinus tumour; Childhood Central Nervous System Yolk Sac Neoplasm; Childhood Central Nervous System Yolk Sac Tumor; paediatric central nervous system endodermal sinus neoplasm; Pediatric Central Nervous System Endodermal Sinus Neoplasm; pediatric central nervous system endodermal sinus neoplasm; Pediatric Central Nervous System Endodermal Sinus Tumor; Pediatric Central Nervous System Yolk Sac Neoplasm; Pediatric Central Nervous System Yolk Sac Tumor
 
Monarch Initiative: MONDO:0003401

Definition

A yolk sac tumor that arises from the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system endodermal sinus tumor

Professional guidelines

PubMed

Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Guerra RN, Oliveira-Junior JJ, Mouchrek-Filho JC, Liberio SA, Lima MV, Paim DB, Brito CX, Mendonça C, Nascimento FR, Pereira AL
J Oral Pathol Med 2012 Aug;41(7):527-32. Epub 2012 Jun 12 doi: 10.1111/j.1600-0714.2012.01165.x. PMID: 22687139
Preliminary observations for a new treatment in children with primary intracranial yolk sac tumor or embryonal carcinoma. Report of five cases.
Ushio Y, Kochi M, Kuratsu J, Itoyama Y, Marubayashi T
J Neurosurg 1999 Jan;90(1):133-7. doi: 10.3171/jns.1999.90.1.0133. PMID: 10413166
Pineal region masses: differential diagnosis.
Smirniotopoulos JG, Rushing EJ, Mena H
Radiographics 1992 May;12(3):577-96. doi: 10.1148/radiographics.12.3.1609147. PMID: 1609147

Recent clinical studies

Etiology

Clinical characteristics and prognostic factors of male yolk sac tumor: a Surveillance, Epidemiology, and End Results program study.
Geng R, Zheng Z, Lin Y, Li Y, Ge G, Zhang J, Wang C, Dai X, Ye Q, Zhen J, Zhang Y, Fu C, Li Y
World J Urol 2021 Apr;39(4):1211-1217. Epub 2020 Jun 19 doi: 10.1007/s00345-020-03311-y. PMID: 32562046
Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report.
Mukasa A, Yanagisawa S, Saito K, Tanaka S, Takai K, Shibahara J, Ikegami M, Nakao Y, Takeshita K, Matsutani M, Saito N
J Neurosurg Spine 2017 Mar;26(3):319-324. Epub 2016 Dec 2 doi: 10.3171/2016.8.SPINE16465. PMID: 27911225
Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571
Frontal intraparenchymal schwannoma: an unusual presentation.
Vaishya S, Sharma MS
Childs Nerv Syst 2004 Apr;20(4):247-50. Epub 2004 Jan 13 doi: 10.1007/s00381-003-0852-8. PMID: 14722719
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Diagnosis

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review.
Isaji T, Iwami K, Ato F, Watanabe T, Takahashi E, Miyachi S
Intern Med 2023 Mar 15;62(6):915-921. Epub 2022 Aug 20 doi: 10.2169/internalmedicine.9447-22. PMID: 35989277Free PMC Article
Two Male Infants each with a Cerebellar Mass.
Jung Koh E, Kim SK, Park SH, Yeoun Lee J, Wang KC, Hoon Phi J
Brain Pathol 2019 Jan;29(1):143-144. doi: 10.1111/bpa.12683. PMID: 30600595Free PMC Article
The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review.
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195
Pineal region masses: differential diagnosis.
Smirniotopoulos JG, Rushing EJ, Mena H
Radiographics 1992 May;12(3):577-96. doi: 10.1148/radiographics.12.3.1609147. PMID: 1609147
Successful treatment of a pineal endodermal sinus tumor. Case report.
Kirkove CS, Brown AP, Symon L
J Neurosurg 1991 May;74(5):832-6. doi: 10.3171/jns.1991.74.5.0832. PMID: 2013783

Therapy

Intracranial endodermal sinus tumors associated with growth hormone replacement therapy in a girl.
Tang Z, Shi X, Singh Khatri Chhetri KI, Qi X
J Neurosurg Pediatr 2012 Jan;9(1):49-53. doi: 10.3171/2011.10.PEDS1195. PMID: 22208321
Testicular cancer metastatic exclusively to the brain and spleen.
Nguyen MM, Corr AS, Evans CP
Urology 2004 Jan;63(1):176-8. doi: 10.1016/j.urology.2003.08.021. PMID: 14751386
An unusual presentation of an intra-parenchymatous frontal yolk sac tumour : case report.
Netalkar AS, Sharma RR, Mahapatra AK, Sousa J, Lad SD, Pawar SJ, Mishra GP, Musa MM
Neurol India 2001 Dec;49(4):395-7. PMID: 11799415
The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review.
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195
Successful treatment of a pineal endodermal sinus tumor. Case report.
Kirkove CS, Brown AP, Symon L
J Neurosurg 1991 May;74(5):832-6. doi: 10.3171/jns.1991.74.5.0832. PMID: 2013783

Prognosis

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review.
Isaji T, Iwami K, Ato F, Watanabe T, Takahashi E, Miyachi S
Intern Med 2023 Mar 15;62(6):915-921. Epub 2022 Aug 20 doi: 10.2169/internalmedicine.9447-22. PMID: 35989277Free PMC Article
Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report.
Mukasa A, Yanagisawa S, Saito K, Tanaka S, Takai K, Shibahara J, Ikegami M, Nakao Y, Takeshita K, Matsutani M, Saito N
J Neurosurg Spine 2017 Mar;26(3):319-324. Epub 2016 Dec 2 doi: 10.3171/2016.8.SPINE16465. PMID: 27911225
Primary skull-based yolk-sac tumour: case report and review of central nervous system germ cell tumours.
Verma R, Malone S, Canil C, Jansen G, Lesiuk H
J Neurooncol 2011 Jan;101(1):129-34. Epub 2010 May 26 doi: 10.1007/s11060-010-0215-8. PMID: 20503065
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184
Frontal intraparenchymal schwannoma: an unusual presentation.
Vaishya S, Sharma MS
Childs Nerv Syst 2004 Apr;20(4):247-50. Epub 2004 Jan 13 doi: 10.1007/s00381-003-0852-8. PMID: 14722719

Clinical prediction guides

Yolk sac tumor of the fourth ventricle in a 3-year-old boy: imaging features.
Ji Q, Ding C, Liu C, Li S
Childs Nerv Syst 2020 Dec;36(12):3123-3128. Epub 2020 Apr 6 doi: 10.1007/s00381-020-04600-y. PMID: 32253490
Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report.
Mukasa A, Yanagisawa S, Saito K, Tanaka S, Takai K, Shibahara J, Ikegami M, Nakao Y, Takeshita K, Matsutani M, Saito N
J Neurosurg Spine 2017 Mar;26(3):319-324. Epub 2016 Dec 2 doi: 10.3171/2016.8.SPINE16465. PMID: 27911225
Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571
Salivary evaluation of pediatric patients with cancer, before and after antineoplasic treatment.
Guerra RN, Oliveira-Junior JJ, Mouchrek-Filho JC, Liberio SA, Lima MV, Paim DB, Brito CX, Mendonça C, Nascimento FR, Pereira AL
J Oral Pathol Med 2012 Aug;41(7):527-32. Epub 2012 Jun 12 doi: 10.1111/j.1600-0714.2012.01165.x. PMID: 22687139
Nestin expression in central nervous system germ cell tumors.
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
Neurosurg Rev 2008 Apr;31(2):173-6; discussion 176-7. Epub 2007 Dec 19 doi: 10.1007/s10143-007-0115-3. PMID: 18092184

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