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Central nervous system germ cell tumor

MedGen UID:
232040
•Concept ID:
C1332880
•
Neoplastic Process
Synonyms: Central Nervous System Germ Cell Neoplasm; central nervous system germ cell neoplasm; Central Nervous System Germ Cell Tumor; central nervous system germ cell tumor; central nervous system rare germ cell tumor; central nervous system rare germ cell tumour; CNS germ cell neoplasm; CNS Germ Cell Tumor; CNS germ cell tumor; CNS germ cell tumour; Germ Cell Neoplasm of Central Nervous System; germ cell neoplasm of central nervous system; Germ Cell Neoplasm of CNS; germ cell neoplasm of CNS; Germ Cell Neoplasm of the Central Nervous System; germ cell neoplasm of the central nervous system; Germ Cell Neoplasm of the CNS; germ cell neoplasm of the CNS; Germ Cell Tumor of Central Nervous System; germ cell tumor of central nervous system; Germ Cell Tumor of CNS; germ cell tumor of CNS; Germ Cell Tumor of the Central Nervous System; germ cell tumor of the central nervous system; Germ Cell Tumor of the CNS; germ cell tumor of the CNS; germ cell tumour of central nervous system; germ cell tumour of CNS; germ cell tumour of the central nervous system; germ cell tumour of the CNS
 
Monarch Initiative: MONDO:0003000

Definition

A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system germ cell tumor

Professional guidelines

PubMed

A novel lactate dehydrogenase-based risk score model to predict the prognosis of primary central nervous system germ cell tumor treated with chemoradiotherapy.
Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients.
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article

Recent clinical studies

Etiology

A novel lactate dehydrogenase-based risk score model to predict the prognosis of primary central nervous system germ cell tumor treated with chemoradiotherapy.
Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor.
Takano M, Kinoshita Y, Sugiyama K, Kolakshyapati M, Takayasu T, Yonezawa U, Taguchi A, Akiyama Y, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
Eur J Radiol 2021 Mar;136:109523. Epub 2021 Jan 7 doi: 10.1016/j.ejrad.2021.109523. PMID: 33460957
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location.
Coutinho V, Dellatolas G, Castaignede-Lalande C, Longaud-Vales A, Kieffer V, Guerrini-Rousseau L, Grill J, Valteau-Couanet D, Dufour C
J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428. doi: 10.1097/MPH.0000000000001200. PMID: 29746441
Delayed surgical resection of central nervous system germ cell tumors.
Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL
Neurosurgery 2002 Apr;50(4):727-33; discussion 733-4. doi: 10.1097/00006123-200204000-00008. PMID: 11904022

Diagnosis

Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor.
Takano M, Kinoshita Y, Sugiyama K, Kolakshyapati M, Takayasu T, Yonezawa U, Taguchi A, Akiyama Y, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
Eur J Radiol 2021 Mar;136:109523. Epub 2021 Jan 7 doi: 10.1016/j.ejrad.2021.109523. PMID: 33460957
Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients.
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Central Nervous System Germ Cell Tumors: A Review of the Literature.
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location.
Coutinho V, Dellatolas G, Castaignede-Lalande C, Longaud-Vales A, Kieffer V, Guerrini-Rousseau L, Grill J, Valteau-Couanet D, Dufour C
J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428. doi: 10.1097/MPH.0000000000001200. PMID: 29746441

Therapy

Delayed surgical resection of central nervous system germ cell tumors.
Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL
Neurosurgery 2002 Apr;50(4):727-33; discussion 733-4. doi: 10.1097/00006123-200204000-00008. PMID: 11904022
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study.
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL
J Clin Oncol 1996 Nov;14(11):2908-15. doi: 10.1200/JCO.1996.14.11.2908. PMID: 8918487

Prognosis

A novel lactate dehydrogenase-based risk score model to predict the prognosis of primary central nervous system germ cell tumor treated with chemoradiotherapy.
Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients.
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study.
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL
J Clin Oncol 1996 Nov;14(11):2908-15. doi: 10.1200/JCO.1996.14.11.2908. PMID: 8918487

Clinical prediction guides

A novel lactate dehydrogenase-based risk score model to predict the prognosis of primary central nervous system germ cell tumor treated with chemoradiotherapy.
Yao DC, Ye BK, Yao DJ, Guo CC
Clin Neurol Neurosurg 2024 Jan;236:108081. Epub 2023 Dec 7 doi: 10.1016/j.clineuro.2023.108081. PMID: 38091701
12p gain is predominantly observed in non-germinomatous germ cell tumors and identifies an unfavorable subgroup of central nervous system germ cell tumors.
Satomi K, Takami H, Fukushima S, Yamashita S, Matsushita Y, Nakazato Y, Suzuki T, Tanaka S, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, Yoshimoto K, Tamura K, Maehara T, Sakai K, Sugiyama K, Yokogami K, Takeshima H, Nonaka M, Asai A, Ushijima T, Matsutani M, Nishikawa R, Ichimura K
Neuro Oncol 2022 May 4;24(5):834-846. doi: 10.1093/neuonc/noab246. PMID: 34698864Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location.
Coutinho V, Dellatolas G, Castaignede-Lalande C, Longaud-Vales A, Kieffer V, Guerrini-Rousseau L, Grill J, Valteau-Couanet D, Dufour C
J Pediatr Hematol Oncol 2018 Oct;40(7):e424-e428. doi: 10.1097/MPH.0000000000001200. PMID: 29746441
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study.
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL
J Clin Oncol 1996 Nov;14(11):2908-15. doi: 10.1200/JCO.1996.14.11.2908. PMID: 8918487

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