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Salivary Gland Ductal Papilloma

MedGen UID:
234768
•Concept ID:
C1335899
•
Neoplastic Process

Definition

A benign papillary neoplasm that arises from the salivary glands. This category includes intraductal papilloma, inverted ductal papilloma, and sialadenoma papilliferum. [from NCI]

Professional guidelines

PubMed

Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm.
Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T
Histopathology 2020 Feb;76(3):411-422. Epub 2019 Dec 1 doi: 10.1111/his.13990. PMID: 31505033

Recent clinical studies

Etiology

Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Retrospective Study of Buccal Mucosal Salivary Neoplasms.
Alramadhan SA, Fitzpatrick SG, Cohen DM, Bhattacharyya I, Islam MN
Head Neck Pathol 2020 Dec;14(4):1013-1020. Epub 2020 Jun 6 doi: 10.1007/s12105-020-01190-8. PMID: 32506376Free PMC Article
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Oral inverted ductal papilloma.
Cabov T, Macan D, Manojlović S, Ozegović M, Spicek J, Luksić I
Br J Oral Maxillofac Surg 2004 Feb;42(1):75-7. doi: 10.1016/s0266-4356(03)00195-5. PMID: 14706310
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248

Diagnosis

Extraoral type of intraductal papilloma in sublingual gland.
Wu L, Wang X, Zhou P, Luo J
Clin Hemorheol Microcirc 2024;87(1):137-139. doi: 10.3233/CH-231717. PMID: 37212087
Activating HRAS mutation in a case of inverted ductal papilloma of the salivary gland.
Ide F, Ito Y, Kikuchi K, Satomura K, Ogawa I, Yamamoto H
Pathol Int 2021 Dec;71(12):844-848. Epub 2021 Sep 21 doi: 10.1111/pin.13166. PMID: 34547823
Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Oral inverted ductal papilloma: not related to HPV.
Do Canto AM, Mistro FZ, Kignel S, Martins F, Palmieri M, Braz-Silva PH
Dermatol Online J 2017 Mar 15;23(3) PMID: 28329525

Therapy

Denture hyperplasia with areas simulating oral inverted ductal papilloma.
Vargas PA, Perez DE, Jorge J, Rangel AL, León JE, Almeida OP
Med Oral Patol Oral Cir Bucal 2005 Jul 1;10 Suppl 2:E117-21. PMID: 15995570

Prognosis

Extraoral type of intraductal papilloma in sublingual gland.
Wu L, Wang X, Zhou P, Luo J
Clin Hemorheol Microcirc 2024;87(1):137-139. doi: 10.3233/CH-231717. PMID: 37212087
Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Oral inverted ductal papilloma.
Cabov T, Macan D, Manojlović S, Ozegović M, Spicek J, Luksić I
Br J Oral Maxillofac Surg 2004 Feb;42(1):75-7. doi: 10.1016/s0266-4356(03)00195-5. PMID: 14706310

Clinical prediction guides

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361
Assessment of p16 expression and HPV infection in adenoid cystic carcinoma of the lacrimal gland.
Wang Y, Tian Y, Lin J, Chen L, Wang L, Hao P, Han R, Ying M, Li X, Tang X
Mol Vis 2018;24:143-152. Epub 2018 Feb 6 PMID: 29430168Free PMC Article
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study.
Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 May;107(5):e34-7. doi: 10.1016/j.tripleo.2009.01.019. PMID: 19426904

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