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Salivary Gland Sialadenoma Papilliferum

MedGen UID:
234770
•Concept ID:
C1335910
•
Neoplastic Process

Definition

An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate. It is generally asymptomatic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Sialadenoma Papilliferum

Professional guidelines

PubMed

Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm.
Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T
Histopathology 2020 Feb;76(3):411-422. Epub 2019 Dec 1 doi: 10.1111/his.13990. PMID: 31505033

Recent clinical studies

Etiology

Pulmonary sialadenoma papilliferum and its mimics: what you need to know.
Gao HW, Sun PL
Histopathology 2022 Dec;81(6):715-723. Epub 2022 Aug 17 doi: 10.1111/his.14733. PMID: 35918179
Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Salivary Sialadenoma Papilliferum Consists of Two Morphologically, Immunophenotypically, and Genetically Distinct Subtypes.
Hsieh MS, Bishop JA, Wang YP, Poh CF, Cheng YL, Lee YH, Jin YT, Chang JYF
Head Neck Pathol 2020 Jun;14(2):489-496. Epub 2019 Aug 31 doi: 10.1007/s12105-019-01068-4. PMID: 31473937Free PMC Article
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248

Diagnosis

Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands.
Sasaki E, Masago K, Kogure Y, Fujita S, Iwakoshi A, Kuroda H, Tsuzuki T, Tsuta K, Matsushita H, Oki M
Mod Pathol 2023 Jun;36(6):100182. Epub 2023 Apr 5 doi: 10.1016/j.modpat.2023.100182. PMID: 37028599
Pulmonary sialadenoma papilliferum and its mimics: what you need to know.
Gao HW, Sun PL
Histopathology 2022 Dec;81(6):715-723. Epub 2022 Aug 17 doi: 10.1111/his.14733. PMID: 35918179
Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature.
Chen S, Peng J, Yuan C, Sun L, Zhang R, Sun Y
Diagn Pathol 2021 Mar 12;16(1):22. doi: 10.1186/s13000-021-01084-5. PMID: 33712056Free PMC Article
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Sialadenoma papilliferum of the bronchus: a rare tumour of salivary gland origin.
Campisi A, Dell'Amore A, Bertolaccini L, Ricci C, Cancellieri A, Stella F
Adv Respir Med 2020;88(3):267-270. doi: 10.5603/ARM.2020.0111. PMID: 32706109

Prognosis

Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Sialadenoma papilliferum of the bronchus: a rare tumour of salivary gland origin.
Campisi A, Dell'Amore A, Bertolaccini L, Ricci C, Cancellieri A, Stella F
Adv Respir Med 2020;88(3):267-270. doi: 10.5603/ARM.2020.0111. PMID: 32706109
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248
Sialadenoma papilliferum.
Cleary KR, Batsakis JG
Ann Otol Rhinol Laryngol 1990 Sep;99(9 Pt 1):756-8. doi: 10.1177/000348949009900918. PMID: 2396815

Clinical prediction guides

Sialadenopapillary Ductal Tumors: Unifying the Spectrum of Sialadenoma Papilliferum-like Tumors With Low Malignant Potential.
Hahn E, Weinreb I, Seethala RR, O'Regan E, Baumhoer D, Bilodeau EA, Gagan J, Sabatini PJB, Ko YCK, Binmadi N, McComb RJ, Leong IT, Bishop JA
Am J Surg Pathol 2025 Jan 1;49(1):45-50. Epub 2024 Oct 30 doi: 10.1097/PAS.0000000000002325. PMID: 39473274
Uncommon case of cytopathological features of sialadenoma papilliferum.
Oyama Y, Nishida H, Kondo Y, Kusaba T, Kawamura K, Fujimoto A, Yokomine Y, Kiyooka S, Iwao S, Hirakawa K, Kawano K, Daa T
Diagn Cytopathol 2023 Jul;51(7):E224-E227. Epub 2023 Apr 13 doi: 10.1002/dc.25139. PMID: 37052154
Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Coexpression of intermediate-sized filaments in sialadenoma papilliferum and other salivary gland neoplasms.
Nakahata A, Deguchi H, Yanagawa T, Yoshida H, Sato M, Hayashi Y
J Oral Pathol Med 1990 Aug;19(7):313-8. doi: 10.1111/j.1600-0714.1990.tb00851.x. PMID: 1700116

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