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Invasive ductal and lobular carcinoma

MedGen UID:
235231
•Concept ID:
C1334277
•
Neoplastic Process
Synonyms: Infiltrating Ductal and Lobular Carcinoma; infiltrating ductal and lobular carcinoma; Invasive Breast Ductal Carcinoma and Lobular Carcinoma; Invasive Duct and Lobular Carcinoma; invasive duct and lobular carcinoma; Invasive Ductal and Lobular Carcinoma; invasive ductal and lobular carcinoma
 
Monarch Initiative: MONDO:0005050

Definition

An invasive ductal breast carcinoma associated with a lobular carcinomatous component. The lobular carcinomatous component may be in situ or invasive. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive ductal and lobular carcinoma

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of invasive ductal and lobular carcinoma: analyses of 54,832 taiwan cancer registry index cases.
Chen BF, Tsai YF, Lien PJ, Lin YS, Feng CJ, Chen YJ, Cheng HF, Tseng LM, Huang CC
Breast Cancer Res Treat 2023 Oct;201(3):547-560. Epub 2023 Jul 20 doi: 10.1007/s10549-023-07044-5. PMID: 37470893
Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage.
Meyer D, Kames J, Bar H, Komar AA, Alexaki A, Ibla J, Hunt RC, Santana-Quintero LV, Golikov A, DiCuccio M, Kimchi-Sarfaty C
Genome Med 2021 Jul 28;13(1):122. doi: 10.1186/s13073-021-00935-6. PMID: 34321100Free PMC Article
ASSESSMENT OF THE VALUE OF METHYLATION FEATURES IN DIFFERENT TISSUES FOR PREOPERATIVE IDENTIFICATION OF HIGH-RISK BREAST TUMORS.
Kankava K, Kvaratskhelia E, Burkadze G, Tsikhiseli G, Azanishvili T, Tkemaladze T, Abzianidze E
Georgian Med News 2019 Apr;(289):143-151. PMID: 31215897

Recent clinical studies

Etiology

Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
Shah OS, Nasrazadani A, Foldi J, Atkinson JM, Kleer CG, McAuliffe PF, Johnston TJ, Stallaert W, da Silva EM, Selenica P, Dopeso H, Pareja F, Mandelker D, Weigelt B, Reis-Filho JS, Bhargava R, Lucas PC, Lee AV, Oesterreich S
Proc Natl Acad Sci U S A 2024 Jul 30;121(31):e2322068121. Epub 2024 Jul 23 doi: 10.1073/pnas.2322068121. PMID: 39042692Free PMC Article
Differentiation of invasive ductal and lobular carcinoma of the breast using MRI radiomic features: a pilot study.
Maiti S, Nayak S, Hebbar KD, Pendem S
F1000Res 2024;13:91. Epub 2024 Mar 14 doi: 10.12688/f1000research.146052.2. PMID: 38571894Free PMC Article
Clinical characteristics and treatment outcomes of invasive ductal and lobular carcinoma: analyses of 54,832 taiwan cancer registry index cases.
Chen BF, Tsai YF, Lien PJ, Lin YS, Feng CJ, Chen YJ, Cheng HF, Tseng LM, Huang CC
Breast Cancer Res Treat 2023 Oct;201(3):547-560. Epub 2023 Jul 20 doi: 10.1007/s10549-023-07044-5. PMID: 37470893
Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic Grade.
Metzger-Filho O, Ferreira AR, Jeselsohn R, Barry WT, Dillon DA, Brock JE, Vaz-Luis I, Hughes ME, Winer EP, Lin NU
Oncologist 2019 Jul;24(7):e441-e449. Epub 2018 Dec 5 doi: 10.1634/theoncologist.2018-0363. PMID: 30518616Free PMC Article
Mixed invasive ductal and lobular carcinoma has distinct clinical features and predicts worse prognosis when stratified by estrogen receptor status.
Xiao Y, Ma D, Ruan M, Zhao S, Liu XY, Jiang YZ, Shao ZM
Sci Rep 2017 Sep 4;7(1):10380. doi: 10.1038/s41598-017-10789-x. PMID: 28871133Free PMC Article

Diagnosis

Differentiation of invasive ductal and lobular carcinoma of the breast using MRI radiomic features: a pilot study.
Maiti S, Nayak S, Hebbar KD, Pendem S
F1000Res 2024;13:91. Epub 2024 Mar 14 doi: 10.12688/f1000research.146052.2. PMID: 38571894Free PMC Article
Clinical characteristics and treatment outcomes of invasive ductal and lobular carcinoma: analyses of 54,832 taiwan cancer registry index cases.
Chen BF, Tsai YF, Lien PJ, Lin YS, Feng CJ, Chen YJ, Cheng HF, Tseng LM, Huang CC
Breast Cancer Res Treat 2023 Oct;201(3):547-560. Epub 2023 Jul 20 doi: 10.1007/s10549-023-07044-5. PMID: 37470893
The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast.
Zhao H
Breast Cancer 2021 Jan;28(1):187-195. Epub 2020 Aug 18 doi: 10.1007/s12282-020-01146-4. PMID: 32812198
Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic Grade.
Metzger-Filho O, Ferreira AR, Jeselsohn R, Barry WT, Dillon DA, Brock JE, Vaz-Luis I, Hughes ME, Winer EP, Lin NU
Oncologist 2019 Jul;24(7):e441-e449. Epub 2018 Dec 5 doi: 10.1634/theoncologist.2018-0363. PMID: 30518616Free PMC Article
Mixed invasive ductal and lobular carcinoma has distinct clinical features and predicts worse prognosis when stratified by estrogen receptor status.
Xiao Y, Ma D, Ruan M, Zhao S, Liu XY, Jiang YZ, Shao ZM
Sci Rep 2017 Sep 4;7(1):10380. doi: 10.1038/s41598-017-10789-x. PMID: 28871133Free PMC Article

Therapy

Utility of four-quadrant random sections in mastectomy specimens.
Gupta D, Nath M, Layfield LJ
Breast J 2003 Jul-Aug;9(4):307-11. doi: 10.1046/j.1524-4741.2003.09411.x. PMID: 12846866

Prognosis

Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
Shah OS, Nasrazadani A, Foldi J, Atkinson JM, Kleer CG, McAuliffe PF, Johnston TJ, Stallaert W, da Silva EM, Selenica P, Dopeso H, Pareja F, Mandelker D, Weigelt B, Reis-Filho JS, Bhargava R, Lucas PC, Lee AV, Oesterreich S
Proc Natl Acad Sci U S A 2024 Jul 30;121(31):e2322068121. Epub 2024 Jul 23 doi: 10.1073/pnas.2322068121. PMID: 39042692Free PMC Article
Distinct signatures of codon and codon pair usage in 32 primary tumor types in the novel database CancerCoCoPUTs for cancer-specific codon usage.
Meyer D, Kames J, Bar H, Komar AA, Alexaki A, Ibla J, Hunt RC, Santana-Quintero LV, Golikov A, DiCuccio M, Kimchi-Sarfaty C
Genome Med 2021 Jul 28;13(1):122. doi: 10.1186/s13073-021-00935-6. PMID: 34321100Free PMC Article
The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast.
Zhao H
Breast Cancer 2021 Jan;28(1):187-195. Epub 2020 Aug 18 doi: 10.1007/s12282-020-01146-4. PMID: 32812198
Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic Grade.
Metzger-Filho O, Ferreira AR, Jeselsohn R, Barry WT, Dillon DA, Brock JE, Vaz-Luis I, Hughes ME, Winer EP, Lin NU
Oncologist 2019 Jul;24(7):e441-e449. Epub 2018 Dec 5 doi: 10.1634/theoncologist.2018-0363. PMID: 30518616Free PMC Article
Mixed invasive ductal and lobular carcinoma has distinct clinical features and predicts worse prognosis when stratified by estrogen receptor status.
Xiao Y, Ma D, Ruan M, Zhao S, Liu XY, Jiang YZ, Shao ZM
Sci Rep 2017 Sep 4;7(1):10380. doi: 10.1038/s41598-017-10789-x. PMID: 28871133Free PMC Article

Clinical prediction guides

Clinical characteristics and treatment outcomes of invasive ductal and lobular carcinoma: analyses of 54,832 taiwan cancer registry index cases.
Chen BF, Tsai YF, Lien PJ, Lin YS, Feng CJ, Chen YJ, Cheng HF, Tseng LM, Huang CC
Breast Cancer Res Treat 2023 Oct;201(3):547-560. Epub 2023 Jul 20 doi: 10.1007/s10549-023-07044-5. PMID: 37470893
The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast.
Zhao H
Breast Cancer 2021 Jan;28(1):187-195. Epub 2020 Aug 18 doi: 10.1007/s12282-020-01146-4. PMID: 32812198
Mixed invasive ductal and lobular carcinoma has distinct clinical features and predicts worse prognosis when stratified by estrogen receptor status.
Xiao Y, Ma D, Ruan M, Zhao S, Liu XY, Jiang YZ, Shao ZM
Sci Rep 2017 Sep 4;7(1):10380. doi: 10.1038/s41598-017-10789-x. PMID: 28871133Free PMC Article
Surgical management of lobular carcinoma from a national screening program: a retrospective analysis.
Sharma SD, Barry M, O'Reilly EA, Kell MR
Eur J Surg Oncol 2015 Jan;41(1):79-85. Epub 2014 Oct 2 doi: 10.1016/j.ejso.2014.09.004. PMID: 25441933
Preoperative breast MRI and surgical outcomes in elderly women with invasive ductal and lobular carcinoma: a population-based study.
Fortune-Greeley AK, Wheeler SB, Meyer AM, Reeder-Hayes KE, Biddle AK, Muss HB, Carpenter WR
Breast Cancer Res Treat 2014 Jan;143(1):203-12. Epub 2013 Dec 4 doi: 10.1007/s10549-013-2787-4. PMID: 24305978Free PMC Article

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