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Recurrent Medulloblastoma

MedGen UID:
235539
•Concept ID:
C1335712
•
Neoplastic Process
Synonym: Relapsed Medulloblastoma

Definition

The reemergence of medulloblastoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.
Kostaras X, Easaw JC
J Neurooncol 2013 Oct;115(1):1-8. Epub 2013 Jul 23 doi: 10.1007/s11060-013-1206-3. PMID: 23877361
PCNU in the treatment of recurrent medulloblastoma and ependymoma--a POG Study.
Ragab AH, Burger P, Badnitsky S, Krischer J, Van Eys J
J Neurooncol 1986;3(4):341-2. doi: 10.1007/BF00165583. PMID: 3958779

Recent clinical studies

Etiology

Rare cases of medulloblastoma with hypermutation.
Bagchi A, Beddows I, Cornelius A, Robinson GW, Jewell SD
Cancer Rep (Hoboken) 2022 May;5(5):e1521. Epub 2021 Aug 5 doi: 10.1002/cnr2.1521. PMID: 34351088Free PMC Article
Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II screening trial.
Levy AS, Krailo M, Chi S, Villaluna D, Springer L, Williams-Hughes C, Fouladi M, Gajjar A
Pediatr Blood Cancer 2021 Aug;68(8):e29031. Epub 2021 Apr 12 doi: 10.1002/pbc.29031. PMID: 33844469Free PMC Article
Surgery for recurrent medulloblastoma: A review.
Rolland A, Aquilina K
Neurochirurgie 2021 Feb;67(1):69-75. Epub 2019 Jul 24 doi: 10.1016/j.neuchi.2019.06.008. PMID: 31351079
Targeting the medulloblastoma: a molecular-based approach.
Luzzi S, Giotta Lucifero A, Brambilla I, Semeria Mantelli S, Mosconi M, Foiadelli T, Savasta S
Acta Biomed 2020 Jun 30;91(7-S):79-100. doi: 10.23750/abm.v91i7-S.9958. PMID: 32608377Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article

Diagnosis

Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen: A Nonrandomized Controlled Trial.
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Rare cases of medulloblastoma with hypermutation.
Bagchi A, Beddows I, Cornelius A, Robinson GW, Jewell SD
Cancer Rep (Hoboken) 2022 May;5(5):e1521. Epub 2021 Aug 5 doi: 10.1002/cnr2.1521. PMID: 34351088Free PMC Article
Surgery for recurrent medulloblastoma: A review.
Rolland A, Aquilina K
Neurochirurgie 2021 Feb;67(1):69-75. Epub 2019 Jul 24 doi: 10.1016/j.neuchi.2019.06.008. PMID: 31351079
Targeting the medulloblastoma: a molecular-based approach.
Luzzi S, Giotta Lucifero A, Brambilla I, Semeria Mantelli S, Mosconi M, Foiadelli T, Savasta S
Acta Biomed 2020 Jun 30;91(7-S):79-100. doi: 10.23750/abm.v91i7-S.9958. PMID: 32608377Free PMC Article
Infectious meningitis mimicking recurrent medulloblastoma on magnetic resonance imaging. Case report.
Fouladi M, Heideman R, Langston JW, Kun LE, Thompson SJ, Gajjar A
J Neurosurg 1999 Sep;91(3):499-502. doi: 10.3171/jns.1999.91.3.0499. PMID: 10470828

Therapy

Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen: A Nonrandomized Controlled Trial.
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II screening trial.
Levy AS, Krailo M, Chi S, Villaluna D, Springer L, Williams-Hughes C, Fouladi M, Gajjar A
Pediatr Blood Cancer 2021 Aug;68(8):e29031. Epub 2021 Apr 12 doi: 10.1002/pbc.29031. PMID: 33844469Free PMC Article
Surgery for recurrent medulloblastoma: A review.
Rolland A, Aquilina K
Neurochirurgie 2021 Feb;67(1):69-75. Epub 2019 Jul 24 doi: 10.1016/j.neuchi.2019.06.008. PMID: 31351079
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Infectious meningitis mimicking recurrent medulloblastoma on magnetic resonance imaging. Case report.
Fouladi M, Heideman R, Langston JW, Kun LE, Thompson SJ, Gajjar A
J Neurosurg 1999 Sep;91(3):499-502. doi: 10.3171/jns.1999.91.3.0499. PMID: 10470828

Prognosis

Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.
Echavidre W, Durivault J, Gotorbe C, Blanchard T, Pagnuzzi M, Vial V, Raes F, Broisat A, Villeneuve R, Amblard R, Garnier N, Ortholan C, Faraggi M, Serrano B, Picco V, Montemagno C
Cancer Res Commun 2023 Dec 7;3(12):2483-2496. doi: 10.1158/2767-9764.CRC-23-0298. PMID: 38009896Free PMC Article
Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen: A Nonrandomized Controlled Trial.
Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II screening trial.
Levy AS, Krailo M, Chi S, Villaluna D, Springer L, Williams-Hughes C, Fouladi M, Gajjar A
Pediatr Blood Cancer 2021 Aug;68(8):e29031. Epub 2021 Apr 12 doi: 10.1002/pbc.29031. PMID: 33844469Free PMC Article
Surgery for recurrent medulloblastoma: A review.
Rolland A, Aquilina K
Neurochirurgie 2021 Feb;67(1):69-75. Epub 2019 Jul 24 doi: 10.1016/j.neuchi.2019.06.008. PMID: 31351079
Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.
O'Reilly SM, Newlands ES, Glaser MG, Brampton M, Rice-Edwards JM, Illingworth RD, Richards PG, Kennard C, Colquhoun IR, Lewis P
Eur J Cancer 1993;29A(7):940-2. doi: 10.1016/s0959-8049(05)80198-4. PMID: 8499146

Clinical prediction guides

Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.
Echavidre W, Durivault J, Gotorbe C, Blanchard T, Pagnuzzi M, Vial V, Raes F, Broisat A, Villeneuve R, Amblard R, Garnier N, Ortholan C, Faraggi M, Serrano B, Picco V, Montemagno C
Cancer Res Commun 2023 Dec 7;3(12):2483-2496. doi: 10.1158/2767-9764.CRC-23-0298. PMID: 38009896Free PMC Article
Outcomes of intraventricular 131-I-omburtamab and external beam radiotherapy in patients with recurrent medulloblastoma and ependymoma.
Tringale KR, Wolden SL, Karajannis M, Haque S, Pasquini L, Yildirim O, Rosenblum M, Benhamida JK, Cheung NK, Souweidane M, Basu EM, Pandit-Taskar N, Zanzonico PB, Humm JL, Kramer K
J Neurooncol 2023 Mar;162(1):69-78. Epub 2023 Feb 28 doi: 10.1007/s11060-022-04235-w. PMID: 36853490Free PMC Article
Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II screening trial.
Levy AS, Krailo M, Chi S, Villaluna D, Springer L, Williams-Hughes C, Fouladi M, Gajjar A
Pediatr Blood Cancer 2021 Aug;68(8):e29031. Epub 2021 Apr 12 doi: 10.1002/pbc.29031. PMID: 33844469Free PMC Article
Biallelic loss of GNAS in a patient with pediatric medulloblastoma.
Tokita MJ, Nahas S, Briggs B, Malicki DM, Mesirov JP, Reyes IAC, Farnaes L, Levy ML, Kingsmore SF, Dimmock D, Crawford JR, Wechsler-Reya RJ
Cold Spring Harb Mol Case Stud 2019 Oct;5(5) Epub 2019 Oct 23 doi: 10.1101/mcs.a004572. PMID: 31624069Free PMC Article
Reirradiation of recurrent medulloblastoma: does clinical benefit outweigh risk for toxicity?
Wetmore C, Herington D, Lin T, Onar-Thomas A, Gajjar A, Merchant TE
Cancer 2014 Dec 1;120(23):3731-7. Epub 2014 Jul 30 doi: 10.1002/cncr.28907. PMID: 25080363Free PMC Article

Recent systematic reviews

Management of recurrent medulloblastoma in adult patients: a systematic review and recommendations.
Kostaras X, Easaw JC
J Neurooncol 2013 Oct;115(1):1-8. Epub 2013 Jul 23 doi: 10.1007/s11060-013-1206-3. PMID: 23877361

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