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Spinal cord lymphoma

MedGen UID:
236836
•Concept ID:
C1336044
•
Neoplastic Process
Synonyms: Lymphoma of Spinal Cord; lymphoma of spinal cord; Lymphoma of the Spinal Cord; lymphoma of the spinal cord; Primary Spinal Cord Lymphoma; primary spinal cord lymphoma; spinal cord cancer; Spinal Cord Lymphoma; spinal cord lymphoma
 
Monarch Initiative: MONDO:0001892

Definition

A non-Hodgkin or Hodgkin lymphoma that arises in the spinal cord as a primary lesion. [from NCI]

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
Neuro Oncol 2019 Feb 19;21(3):296-305. doi: 10.1093/neuonc/noy192. PMID: 30418592Free PMC Article
Clinical Evaluation and Management of Radiation Fibrosis Syndrome.
Stubblefield MD
Phys Med Rehabil Clin N Am 2017 Feb;28(1):89-100. doi: 10.1016/j.pmr.2016.08.003. PMID: 27913002

Recent clinical studies

Etiology

Nomograms Predict Survival Outcome of Primary Intramedullary Spinal Cord Lymphoma Patients.
Wu Q, Yang Z, Xu Y
Med Sci Monit 2019 Oct 3;25:7418-7429. doi: 10.12659/MSM.919628. PMID: 31579048Free PMC Article
Primary B-cell Spinal Cord Lymphoma of the Cervical Spine.
Guzik G
Ortop Traumatol Rehabil 2018 Jun 30;20(3):219-227. doi: 10.5604/01.3001.0012.2131. PMID: 30152771
Primary intramedullary spinal cord lymphoma: a population-based study.
Yang W, Garzon-Muvdi T, Braileanu M, Porras JL, Caplan JM, Rong X, Huang J, Jallo GI
Neuro Oncol 2017 Mar 1;19(3):414-421. doi: 10.1093/neuonc/now178. PMID: 28011925Free PMC Article
Spinal cord tumors: new views and future directions.
Mechtler LL, Nandigam K
Neurol Clin 2013 Feb;31(1):241-68. doi: 10.1016/j.ncl.2012.09.011. PMID: 23186903
Primary intramedullary spinal cord lymphoma.
Flanagan EP, O'Neill BP, Porter AB, Lanzino G, Haberman TM, Keegan BM
Neurology 2011 Aug 23;77(8):784-91. Epub 2011 Aug 10 doi: 10.1212/WNL.0b013e31822b00b9. PMID: 21832220

Diagnosis

Primary intramedullary spinal-cord lymphoma (PISCL): a rare entity with a challenging diagnosis.
Martins ES, Duque C, Rebelo O, Batista S
BMJ Case Rep 2021 May 19;14(5) doi: 10.1136/bcr-2021-242548. PMID: 34011646Free PMC Article
Primary intramedullary spinal cord lymphoma: a population-based study.
Yang W, Garzon-Muvdi T, Braileanu M, Porras JL, Caplan JM, Rong X, Huang J, Jallo GI
Neuro Oncol 2017 Mar 1;19(3):414-421. doi: 10.1093/neuonc/now178. PMID: 28011925Free PMC Article
Primary CNS T-cell lymphoma of the spinal cord: case report and literature review.
Guzzetta M, Drexler S, Buonocore B, Donovan V
Lab Med 2015 Spring;46(2):159-63. doi: 10.1309/LM85GPXDT8NJSDAB. PMID: 25918197
Spinal cord tumors: new views and future directions.
Mechtler LL, Nandigam K
Neurol Clin 2013 Feb;31(1):241-68. doi: 10.1016/j.ncl.2012.09.011. PMID: 23186903
Primary intramedullary spinal cord lymphoma.
Flanagan EP, O'Neill BP, Porter AB, Lanzino G, Haberman TM, Keegan BM
Neurology 2011 Aug 23;77(8):784-91. Epub 2011 Aug 10 doi: 10.1212/WNL.0b013e31822b00b9. PMID: 21832220

Therapy

Life threatening rare lymphomas presenting as longitudinally extensive transverse myelitis: a diagnostic challenge.
Tolvaj B, Hahn K, Nagy Z, Vadvári Á, Csomor J, Gelpi E, Illes Z, Garzuly F
Ideggyogy Sz 2020 Jul 30;73(7-08):275-285. doi: 10.18071/isz.73.0275. PMID: 32750245
Primary B-cell Spinal Cord Lymphoma of the Cervical Spine.
Guzik G
Ortop Traumatol Rehabil 2018 Jun 30;20(3):219-227. doi: 10.5604/01.3001.0012.2131. PMID: 30152771
Central nervous system lymphoproliferative disorder in pediatric kidney transplant recipients.
Traum AZ, Rodig NM, Pilichowska ME, Somers MJ
Pediatr Transplant 2006 Jun;10(4):505-12. doi: 10.1111/j.1399-3046.2006.00497.x. PMID: 16712612

Prognosis

Survival Outcome and Prognostic Factors of Primary Spinal Cord Lymphoma.
Qianjin D, Zhenguo C, Yang W, Baoshun D, Laiguang S
Turk Neurosurg 2024;34(2):216-223. doi: 10.5137/1019-5149.JTN.41081-22.3. PMID: 38497173
Nomograms Predict Survival Outcome of Primary Intramedullary Spinal Cord Lymphoma Patients.
Wu Q, Yang Z, Xu Y
Med Sci Monit 2019 Oct 3;25:7418-7429. doi: 10.12659/MSM.919628. PMID: 31579048Free PMC Article
Primary intramedullary spinal cord lymphoma: a population-based study.
Yang W, Garzon-Muvdi T, Braileanu M, Porras JL, Caplan JM, Rong X, Huang J, Jallo GI
Neuro Oncol 2017 Mar 1;19(3):414-421. doi: 10.1093/neuonc/now178. PMID: 28011925Free PMC Article
Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report.
Taylor JW, Flanagan EP, O'Neill BP, Siegal T, Omuro A, Deangelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, Hoang-Xuan K, Gonzalez-Aguilar A, Batchelor T, Blay JY, Korfel A, Betensky RA, Lopes MB, Schiff D
Neurology 2013 Nov 5;81(19):1690-6. Epub 2013 Oct 9 doi: 10.1212/01.wnl.0000435302.02895.f3. PMID: 24107866Free PMC Article
Primary intramedullary spinal cord lymphoma.
Flanagan EP, O'Neill BP, Porter AB, Lanzino G, Haberman TM, Keegan BM
Neurology 2011 Aug 23;77(8):784-91. Epub 2011 Aug 10 doi: 10.1212/WNL.0b013e31822b00b9. PMID: 21832220

Clinical prediction guides

Survival Outcome and Prognostic Factors of Primary Spinal Cord Lymphoma.
Qianjin D, Zhenguo C, Yang W, Baoshun D, Laiguang S
Turk Neurosurg 2024;34(2):216-223. doi: 10.5137/1019-5149.JTN.41081-22.3. PMID: 38497173
Nomograms Predict Survival Outcome of Primary Intramedullary Spinal Cord Lymphoma Patients.
Wu Q, Yang Z, Xu Y
Med Sci Monit 2019 Oct 3;25:7418-7429. doi: 10.12659/MSM.919628. PMID: 31579048Free PMC Article
Primary intramedullary spinal cord lymphoma: a population-based study.
Yang W, Garzon-Muvdi T, Braileanu M, Porras JL, Caplan JM, Rong X, Huang J, Jallo GI
Neuro Oncol 2017 Mar 1;19(3):414-421. doi: 10.1093/neuonc/now178. PMID: 28011925Free PMC Article

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