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Central nervous system hematopoietic neoplasm

MedGen UID:
234101
•Concept ID:
C1332882
•
Neoplastic Process
Synonyms: central nervous system haematopoietic and lymphoid system neoplasm; central nervous system haematopoietic neoplasms; central nervous system haematopoietic tumour; central nervous system hematologic cancer; Central Nervous System Hematopoietic and Lymphoid Cell Neoplasm; central nervous system hematopoietic and lymphoid system neoplasm; Central Nervous System Hematopoietic Neoplasm; central nervous system hematopoietic neoplasm; Central Nervous System Hematopoietic Neoplasms; central nervous system hematopoietic neoplasms; Central Nervous System Hematopoietic Tumor; central nervous system hematopoietic tumor; CNS haematopoietic neoplasm; CNS haematopoietic tumour; CNS Hematopoietic Neoplasm; CNS hematopoietic neoplasm; CNS Hematopoietic Tumor; CNS hematopoietic tumor; haematopoietic and lymphoid system neoplasm of central nervous system; haematopoietic neoplasm of central nervous system; haematopoietic neoplasm of CNS; haematopoietic neoplasm of the central nervous system; haematopoietic neoplasm of the CNS; haematopoietic tumour of central nervous system; haematopoietic tumour of the central nervous system; hematopoietic and lymphoid system neoplasm of central nervous system; Hematopoietic Neoplasm of Central Nervous System; hematopoietic neoplasm of central nervous system; Hematopoietic Neoplasm of CNS; hematopoietic neoplasm of CNS; Hematopoietic Neoplasm of the Central Nervous System; hematopoietic neoplasm of the central nervous system; Hematopoietic Neoplasm of the CNS; hematopoietic neoplasm of the CNS; Hematopoietic Tumor of Central Nervous System; hematopoietic tumor of central nervous system; Hematopoietic Tumor of the Central Nervous System; hematopoietic tumor of the central nervous system; Lymphomas and Hemopoietic Neoplasms of CNS; lymphomas and hemopoietic neoplasms of CNS; Lymphomas and Hemopoietic Neoplasms of the CNS; lymphomas and hemopoietic neoplasms of the CNS
 
Monarch Initiative: MONDO:0003641

Definition

A neoplasm of hematopoietic and lymphoid cell origin that affects the brain, meninges, or spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system hematopoietic neoplasm

Professional guidelines

PubMed

Inpatient recognition and management of HLH.
Zoref-Lorenz A, Ellis M, Jordan MB
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):259-266. doi: 10.1182/hematology.2023000509. PMID: 38066887Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490

Recent clinical studies

Etiology

Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Cytokines in CAR T Cell-Associated Neurotoxicity.
Gust J, Ponce R, Liles WC, Garden GA, Turtle CJ
Front Immunol 2020;11:577027. Epub 2020 Dec 16 doi: 10.3389/fimmu.2020.577027. PMID: 33391257Free PMC Article
Blastic Plasmacytoid Dendritic Cell Neoplasm in Children.
Li Y, Sun V, Sun W, Pawlowska A
Hematol Oncol Clin North Am 2020 Jun;34(3):601-612. Epub 2020 Mar 9 doi: 10.1016/j.hoc.2020.01.008. PMID: 32336423
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
Garcia-Manero G, Kantarjian HM
Hematol Oncol Clin North Am 2000 Dec;14(6):1381-96, x-xi. doi: 10.1016/s0889-8588(05)70192-1. PMID: 11147229

Diagnosis

Inpatient recognition and management of HLH.
Zoref-Lorenz A, Ellis M, Jordan MB
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):259-266. doi: 10.1182/hematology.2023000509. PMID: 38066887Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
How I Diagnose Rosai-Dorfman Disease.
Ravindran A, Rech KL
Am J Clin Pathol 2023 Jul 5;160(1):1-10. doi: 10.1093/ajcp/aqad047. PMID: 37167084
Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology.
Pollyea DA, Altman JK, Assi R, Bixby D, Fathi AT, Foran JM, Gojo I, Hall AC, Jonas BA, Kishtagari A, Lancet J, Maness L, Mangan J, Mannis G, Marcucci G, Mims A, Moriarty K, Mustafa Ali M, Neff J, Nejati R, Olin R, Percival ME, Perl A, Przespolewski A, Rao D, Ravandi F, Shallis R, Shami PJ, Stein E, Stone RM, Sweet K, Thota S, Uy G, Vachhani P, Cassara CJ, Freedman-Cass DA, Stehman K
J Natl Compr Canc Netw 2023 May;21(5):503-513. doi: 10.6004/jnccn.2023.0025. PMID: 37156478
Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article

Therapy

Prevention and management of secondary central nervous system lymphoma.
Bobillo S, Khwaja J, Ferreri AJM, Cwynarski K
Haematologica 2023 Mar 1;108(3):673-689. doi: 10.3324/haematol.2022.281457. PMID: 36384246Free PMC Article
Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Checkpoint inhibition in meningiomas.
Bi WL, Wu WW, Santagata S, Reardon DA, Dunn IF
Immunotherapy 2016 Jun;8(6):721-31. doi: 10.2217/imt-2016-0017. PMID: 27197540
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
Garcia-Manero G, Kantarjian HM
Hematol Oncol Clin North Am 2000 Dec;14(6):1381-96, x-xi. doi: 10.1016/s0889-8588(05)70192-1. PMID: 11147229

Prognosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies.
Vadillo E, Dorantes-Acosta E, Pelayo R, Schnoor M
Blood Rev 2018 Jan;32(1):36-51. Epub 2017 Aug 15 doi: 10.1016/j.blre.2017.08.006. PMID: 28830639
Checkpoint inhibition in meningiomas.
Bi WL, Wu WW, Santagata S, Reardon DA, Dunn IF
Immunotherapy 2016 Jun;8(6):721-31. doi: 10.2217/imt-2016-0017. PMID: 27197540

Clinical prediction guides

Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease.
Abla O
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):386-395. doi: 10.1182/hematology.2023000439. PMID: 38066856Free PMC Article
Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant.
Scordo M, Wang TP, Ahn KW, Chen Y, Ahmed S, Awan FT, Beitinjaneh A, Chen A, Chow VA, Dholaria B, Epperla N, Farooq U, Ghosh N, Grover N, Hamad N, Hildebrandt GC, Holmberg L, Hong S, Inwards DJ, Jimenez-Jimenez A, Karmali R, Kenkre VP, Khimani F, Klyuchnikov E, Krem MM, Munshi PN, Nieto Y, Prestidge T, Ramakrishnan Geethakumari P, Rezvani AR, Riedell PA, Seo S, Shah NN, Solh M, Yared JA, Kharfan-Dabaja MA, Herrera A, Hamadani M, Sauter CS
JAMA Oncol 2021 Jul 1;7(7):993-1003. doi: 10.1001/jamaoncol.2021.1074. PMID: 33956047Free PMC Article
Literature review on cancer risk in children born after fertility treatment suggests increased risk of haematological cancers.
Reigstad MM, Oldereid NB, Omland AK, Storeng R
Acta Paediatr 2017 May;106(5):698-709. Epub 2017 Mar 3 doi: 10.1111/apa.13755. PMID: 28128867
Checkpoint inhibition in meningiomas.
Bi WL, Wu WW, Santagata S, Reardon DA, Dunn IF
Immunotherapy 2016 Jun;8(6):721-31. doi: 10.2217/imt-2016-0017. PMID: 27197540
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
Omuro A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS
Blood 2015 Feb 26;125(9):1403-10. Epub 2015 Jan 7 doi: 10.1182/blood-2014-10-604561. PMID: 25568347Free PMC Article

Recent systematic reviews

Bruton's Tyrosine Kinase Inhibitors in Refractory or Relapsing Primary Central Nervous System Lymphoma: A Meta-analysis and Systematic Review.
Guo HP, Dang XL, Kang L, Liu C, Liu XW
World Neurosurg 2024 Aug;188:161-169. Epub 2024 Apr 17 doi: 10.1016/j.wneu.2024.04.066. PMID: 38641241
Autologous hematopoietic cell transplantation versus whole-brain radiotherapy consolidation in primary central nervous system lymphoma: A systematic review and meta-analysis.
Epperla N, Reljic T, Chowdhury SM, Ferreri AJM, Kumar A, Hamadani M
Hematol Oncol 2023 Feb;41(1):88-96. Epub 2022 Oct 6 doi: 10.1002/hon.3083. PMID: 36192141
Optimum Methotrexate Exposure in Patients With Suspected or Confirmed CNS Invasive Hematological Malignancies: A Systematic Critical Review.
Faria MJ, Rita D, Rui B, Fernanda T
Ther Drug Monit 2023 Jun 1;45(3):287-292. Epub 2023 Jan 10 doi: 10.1097/FTD.0000000000001022. PMID: 35971672
Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review.
Madsen ML, Due H, Ejskjær N, Jensen P, Madsen J, Dybkær K
Cancer Chemother Pharmacol 2019 Sep;84(3):471-485. Epub 2019 Jun 18 doi: 10.1007/s00280-019-03884-5. PMID: 31214762Free PMC Article
Literature review on cancer risk in children born after fertility treatment suggests increased risk of haematological cancers.
Reigstad MM, Oldereid NB, Omland AK, Storeng R
Acta Paediatr 2017 May;106(5):698-709. Epub 2017 Mar 3 doi: 10.1111/apa.13755. PMID: 28128867

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