U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Testicular Mixed Embryonal Carcinoma and Seminoma

MedGen UID:
237003
•Concept ID:
C1336715
•
Neoplastic Process
Synonyms: Mixed Embryonal Carcinoma and Seminoma of Testis; Mixed Embryonal Carcinoma and Seminoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Embryonal Carcinoma and Seminoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Clues from natural history and results of treatment supporting the monoclonal origin of germ cell tumours.
Oliver RT
Cancer Surv 1990;9(2):333-68. PMID: 1964626

Recent clinical studies

Etiology

Survival of Testicular Pure Embryonal Carcinoma vs. Mixed Germ Cell Tumor Patients across All Stages.
Cano Garcia C, Panunzio A, Tappero S, Piccinelli ML, Barletta F, Incesu RB, Law KW, Scheipner L, Tian Z, Saad F, Shariat SF, Tilki D, Briganti A, De Cobelli O, Terrone C, Antonelli A, Banek S, Kluth LA, Chun FKH, Karakiewicz PI
Medicina (Kaunas) 2023 Feb 24;59(3) doi: 10.3390/medicina59030451. PMID: 36984452Free PMC Article
SOX2 and PRAME in the "reprogramming" of seminoma cells.
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34.
Ricci C, Franceschini T, Giunchi F, Borsato M, Mollica V, Massari F, Fiorentino M
Pathol Res Pract 2021 Nov;227:153637. Epub 2021 Sep 29 doi: 10.1016/j.prp.2021.153637. PMID: 34619577
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Sodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas.
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572

Diagnosis

Cytological spectrum of testicular malignancies with histopathological correlation: A retrospective analysis.
Kerkar A, Kundu R, Kaur A, Rohilla M, Gupta P, Gupta N, Srinivasan R, Kakkar N, Dey P
Diagn Cytopathol 2023 Oct;51(10):646-653. Epub 2023 Jul 14 doi: 10.1002/dc.25194. PMID: 37452481
Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34.
Ricci C, Franceschini T, Giunchi F, Borsato M, Mollica V, Massari F, Fiorentino M
Pathol Res Pract 2021 Nov;227:153637. Epub 2021 Sep 29 doi: 10.1016/j.prp.2021.153637. PMID: 34619577
Malignant germ cell tumours in the elderly: a histopathological review of 50 cases in men aged 60 years or over.
Berney DM, Warren AY, Verma M, Kudahetti S, Robson JM, Williams MW, Neal DE, Powles T, Shamash J, Oliver RT
Mod Pathol 2008 Jan;21(1):54-9. Epub 2007 Nov 2 doi: 10.1038/modpathol.3800978. PMID: 17975539
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Therapy

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.
Jostes S, Nettersheim D, Fellermeyer M, Schneider S, Hafezi F, Honecker F, Schumacher V, Geyer M, Kristiansen G, Schorle H
J Cell Mol Med 2017 Jul;21(7):1300-1314. Epub 2016 Dec 27 doi: 10.1111/jcmm.13059. PMID: 28026145Free PMC Article
Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Pagliaro LC
J Clin Oncol 2017 Apr 1;35(10):1036-1040. Epub 2016 Dec 19 doi: 10.1200/JCO.2016.70.6523. PMID: 27992270
Metastatic mixed germ-cell neoplasm presenting as retinal detachment.
Phelps PO, Kapadia AA, Chennuri R, Mehta DG
J Clin Oncol 2012 May 1;30(13):e133-6. Epub 2012 Mar 5 doi: 10.1200/JCO.2011.38.2093. PMID: 22393102
Recurrent seminomas: clinical features and biologic implications.
Som A, Zhu R, Guo CC, Efstathiou E, Xiao L, Pisters LL, Matin A, Tu SM
Urol Oncol 2012 Jul-Aug;30(4):494-501. Epub 2010 Sep 6 doi: 10.1016/j.urolonc.2010.05.011. PMID: 20822932Free PMC Article
Spermatic cord contamination in testicular cancer.
Nazeer T, Ro JY, Kee KH, Ayala AG
Mod Pathol 1996 Jul;9(7):762-6. PMID: 8832559

Prognosis

Age-incidence patterns of seminoma and nonseminoma among males and females in Germany and the United States, 2008-2016.
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34.
Ricci C, Franceschini T, Giunchi F, Borsato M, Mollica V, Massari F, Fiorentino M
Pathol Res Pract 2021 Nov;227:153637. Epub 2021 Sep 29 doi: 10.1016/j.prp.2021.153637. PMID: 34619577
Sodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas.
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572
Metastatic mixed germ-cell neoplasm presenting as retinal detachment.
Phelps PO, Kapadia AA, Chennuri R, Mehta DG
J Clin Oncol 2012 May 1;30(13):e133-6. Epub 2012 Mar 5 doi: 10.1200/JCO.2011.38.2093. PMID: 22393102
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Clinical prediction guides

TAMs PD-L1(+) in the reprogramming of germ cell tumors of the testis.
Melotti S, Ambrosi F, Franceschini T, Giunchi F, Filippo GD, Franchini E, Massari F, Mollica V, Tateo V, Bianchi FM, Colecchia M, Acosta AM, Lobo J, Fiorentino M, Ricci C
Pathol Res Pract 2023 Jul;247:154540. Epub 2023 May 18 doi: 10.1016/j.prp.2023.154540. PMID: 37209574
Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
SOX2 and PRAME in the "reprogramming" of seminoma cells.
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34.
Ricci C, Franceschini T, Giunchi F, Borsato M, Mollica V, Massari F, Fiorentino M
Pathol Res Pract 2021 Nov;227:153637. Epub 2021 Sep 29 doi: 10.1016/j.prp.2021.153637. PMID: 34619577
Sodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas.
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...