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Benign ovarian mucinous tumor

MedGen UID:
267038
•Concept ID:
C1511100
•
Neoplastic Process
Synonyms: Benign Ovarian Mucinous Neoplasm; benign ovarian mucinous neoplasm; Benign Ovarian Mucinous Tumor; benign ovarian mucinous tumor; ovarian mucinous neoplasm, benign
 
Monarch Initiative: MONDO:0036915

Definition

A non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of neoplastic epithelium that resembles the epithelium of the endocervix or gastrointestinal tract. There is no evidence of atypia. It includes mucinous adenofibroma, mucinous cystadenofibroma, and mucinous cystadenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign ovarian mucinous tumor

Professional guidelines

PubMed

Retrospective Study of the Epidemiology, Pathology, and Therapeutic Management in Patients With Mucinous Ovarian Tumors.
Zhang Y, Li C, Luo S, Su Y, Gang X, Chu P, Zhang J, Wu H, Liu G
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820946423. doi: 10.1177/1533033820946423. PMID: 32783505Free PMC Article

Recent clinical studies

Etiology

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Low-grade Serous Neoplasia of the Female Genital Tract.
Folkins AK, Longacre TA
Surg Pathol Clin 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006. PMID: 31097112
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article
Well-differentiated serous neoplasms of the ovary.
Longacre TA, Kempson RL, Hendrickson MR
Pathology (Phila) 1993;1(2):255-306. PMID: 9420921

Diagnosis

Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Low-grade Serous Neoplasia of the Female Genital Tract.
Folkins AK, Longacre TA
Surg Pathol Clin 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006. PMID: 31097112
Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant.
Williams RM, Lee C, Galassi TV, Harvey JD, Leicher R, Sirenko M, Dorso MA, Shah J, Olvera N, Dao F, Levine DA, Heller DA
Sci Adv 2018 Apr;4(4):eaaq1090. Epub 2018 Apr 18 doi: 10.1126/sciadv.aaq1090. PMID: 29675469Free PMC Article
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Fibrous tumours of the ovary: aetiologies and MRI features.
Montoriol PF, Mons A, Da Ines D, Bourdel N, Tixier L, Garcier JM
Clin Radiol 2013 Dec;68(12):1276-83. Epub 2013 Aug 9 doi: 10.1016/j.crad.2013.07.005. PMID: 23937826

Therapy

A report of twenty cases of ovarian Brenner tumor and literature review: a case series study.
Lou Z, Mei L, Wan Z, Zhang W, Gao J
BMC Womens Health 2024 Aug 27;24(1):471. doi: 10.1186/s12905-024-03316-4. PMID: 39192213Free PMC Article
Discriminative diagnosis of ovarian endometriosis cysts and benign mucinous cystadenomas based on the ConvNeXt algorithm.
Miao K, Lv Q, Zhang L, Zhao N, Dong X
Eur J Obstet Gynecol Reprod Biol 2024 Jul;298:135-139. Epub 2024 May 13 doi: 10.1016/j.ejogrb.2024.05.010. PMID: 38756053
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Intraoperative rupture of benign mucinous cystadenoma does not increase its recurrence rate.
Mizrachi Y, Weiner E, Keidar R, Kerner R, Golan A, Sagiv R
Arch Gynecol Obstet 2015 May;291(5):1135-9. Epub 2014 Nov 12 doi: 10.1007/s00404-014-3543-7. PMID: 25388920
Mucinous tumors of the ovary: current thoughts on diagnosis and management.
Brown J, Frumovitz M
Curr Oncol Rep 2014 Jun;16(6):389. doi: 10.1007/s11912-014-0389-x. PMID: 24777667Free PMC Article

Prognosis

The molecular origin and taxonomy of mucinous ovarian carcinoma.
Cheasley D, Wakefield MJ, Ryland GL, Allan PE, Alsop K, Amarasinghe KC, Ananda S, Anglesio MS, Au-Yeung G, Böhm M, Bowtell DDL, Brand A, Chenevix-Trench G, Christie M, Chiew YE, Churchman M, DeFazio A, Demeo R, Dudley R, Fairweather N, Fedele CG, Fereday S, Fox SB, Gilks CB, Gourley C, Hacker NF, Hadley AM, Hendley J, Ho GY, Hughes S, Hunstman DG, Hunter SM, Jobling TW, Kalli KR, Kaufmann SH, Kennedy CJ, Köbel M, Le Page C, Li J, Lupat R, McNally OM, McAlpine JN, Mes-Masson AM, Mileshkin L, Provencher DM, Pyman J, Rahimi K, Rowley SM, Salazar C, Samimi G, Saunders H, Semple T, Sharma R, Sharpe AJ, Stephens AN, Thio N, Torres MC, Traficante N, Xing Z, Zethoven M, Antill YC, Scott CL, Campbell IG, Gorringe KL
Nat Commun 2019 Sep 2;10(1):3935. doi: 10.1038/s41467-019-11862-x. PMID: 31477716Free PMC Article
Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Well-differentiated serous neoplasms of the ovary.
Longacre TA, Kempson RL, Hendrickson MR
Pathology (Phila) 1993;1(2):255-306. PMID: 9420921

Clinical prediction guides

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Characterization and clinical significance of the CADM1/HER2/STAT3 axis in serous ovarian tumors.
Wu D, Lei Y, Liu Q, Hu H, Li H, Xie L, Zhou J
Medicine (Baltimore) 2021 Feb 26;100(8):e23777. doi: 10.1097/MD.0000000000023777. PMID: 33663040Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Clinical and ultrasound features of benign, borderline, and malignant invasive mucinous ovarian tumors.
Pascual A, Guerriero S, Rams N, Juez L, Ajossa S, Graupera B, Hereter L, Cappai A, Pero M, Perniciano M, Errasti T, Parra J, Solis M, Alcázar JL
Eur J Gynaecol Oncol 2017;38(3):382-386. PMID: 29693878
Unmasking the complexities of mucinous ovarian carcinoma.
Frumovitz M, Schmeler KM, Malpica A, Sood AK, Gershenson DM
Gynecol Oncol 2010 Jun;117(3):491-6. Epub 2010 Mar 23 doi: 10.1016/j.ygyno.2010.02.010. PMID: 20332054Free PMC Article

Recent systematic reviews

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.
Milanetto AC, Tonello AS, Valotto G, Munari G, Luchini C, Fassan M, Pasquali C
Virchows Arch 2021 Jul;479(1):179-189. Epub 2021 Jan 28 doi: 10.1007/s00428-021-03029-1. PMID: 33511431Free PMC Article
Role of Imaging Tools for the Diagnosis of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.
Borrelli GM, de Mattos LA, Andres MP, Gonçalves MO, Kho RM, Abrão MS
J Minim Invasive Gynecol 2017 Mar-Apr;24(3):353-363. Epub 2016 Dec 24 doi: 10.1016/j.jmig.2016.12.012. PMID: 28027973
Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis: a systematic review and meta-analysis.
Macedo AC, da Rosa MI, Lumertz S, Medeiros LR
Int J Gynecol Cancer 2014 Sep;24(7):1222-31. doi: 10.1097/IGC.0000000000000192. PMID: 25078339
A systematic review of papers examining the use of intraoperative frozen section in predicting the final diagnosis of ovarian lesions.
Heatley MK
Int J Gynecol Pathol 2012 Mar;31(2):111-5. doi: 10.1097/PGP.0b013e318226043b. PMID: 22317865

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