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Ovarian mucinous adenofibroma

MedGen UID:
309511
•Concept ID:
C1518723
•
Neoplastic Process
Synonyms: mucinous adenofibroma of ovary; Ovarian Mucinous Adenofibroma; ovarian mucinous adenofibroma; ovary mucinous adenofibroma
 
Monarch Initiative: MONDO:0003887

Definition

A benign neoplasm of the ovary characterized by the presence of glands with mucinous columnar epithelial cells in a fibrotic stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian mucinous adenofibroma

Professional guidelines

PubMed

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Results of treatment of primary ovarian carcinoma.
Saarikoski S, Selander K, Kauppila O, Raitala R, Pystynen P
Ann Chir Gynaecol 1982;71(3):156-60. PMID: 7114781

Recent clinical studies

Etiology

TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Eosinophilic Cells, Autoimplants, Degree of Cellular Proliferation, and Adenofibroma Pattern are Important Histologic Findings in Ovarian Borderline Tumors.
Karpathiou G, Venet M, Chauleur C, Honeyman F, Casteillo F, Peoc'h M
Int J Gynecol Pathol 2017 Sep;36(5):447-452. doi: 10.1097/PGP.0000000000000361. PMID: 28796659
Simple descriptors and simple rules of the International Ovarian Tumor Analysis (IOTA) Group: a prospective study of combined use for the description of adnexal masses.
Peces Rama A, Llanos Llanos MC, Sánchez Ferrer ML, Alcázar Zambrano JL, Martínez Mendoza A, Nieto Díaz A
Eur J Obstet Gynecol Reprod Biol 2015 Dec;195:7-11. Epub 2015 Aug 20 doi: 10.1016/j.ejogrb.2015.07.010. PMID: 26461961
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Endovaginal sonographic appearance of benign ovarian masses.
Atri M, Nazarnia S, Bret PM, Aldis AE, Kintzen G, Reinhold C
Radiographics 1994 Jul;14(4):747-60; discussion 761-2. doi: 10.1148/radiographics.14.4.7938766. PMID: 7938766

Diagnosis

Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series.
Vroobel KM, McCluggage WG
Int J Gynecol Pathol 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768. PMID: 33741765
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Simple descriptors and simple rules of the International Ovarian Tumor Analysis (IOTA) Group: a prospective study of combined use for the description of adnexal masses.
Peces Rama A, Llanos Llanos MC, Sánchez Ferrer ML, Alcázar Zambrano JL, Martínez Mendoza A, Nieto Díaz A
Eur J Obstet Gynecol Reprod Biol 2015 Dec;195:7-11. Epub 2015 Aug 20 doi: 10.1016/j.ejogrb.2015.07.010. PMID: 26461961
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Therapy

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Selective incorporation of total laparoscopic hysterectomy for adnexal pathology and body mass index.
O'Hanlan KA, Huang GS, Lopez L, Garnier AC
Gynecol Oncol 2004 Apr;93(1):137-43. doi: 10.1016/j.ygyno.2003.12.020. PMID: 15047227
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy.
Rose PG, Faulhaber P, Miraldi F, Abdul-Karim FW
Gynecol Oncol 2001 Jul;82(1):17-21. doi: 10.1006/gyno.2001.6246. PMID: 11426956

Prognosis

Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Ovarian carcinomas, including secondary tumors: diagnostically challenging areas.
Prat J
Mod Pathol 2005 Feb;18 Suppl 2:S99-111. doi: 10.1038/modpathol.3800312. PMID: 15492758

Clinical prediction guides

Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma.
Miyama Y, Ogasawara A, Hasegawa K, Yasuda M
Int J Gynecol Pathol 2024 Jul 1;43(4):362-372. Epub 2024 Mar 4 doi: 10.1097/PGP.0000000000001002. PMID: 38870078
TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Clinical value of human epididymis protein 4 and the Risk of Ovarian Malignancy Algorithm in differentiating borderline pelvic tumors from epithelial ovarian cancer in early stages.
Kotowicz B, Fuksiewicz M, Sobiczewski P, Spiewankiewicz B, Jonska-Gmyrek J, Skrzypczak M, Kowalska M
Eur J Obstet Gynecol Reprod Biol 2015 Nov;194:141-6. Epub 2015 Sep 12 doi: 10.1016/j.ejogrb.2015.09.008. PMID: 26398337
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
HISTOCHEMICAL OBSERVATIONS ON MUCINS IN HUMAN OVARIAN NEOPLASMS.
GARCIA-BUNUEL R, MONIS B
Cancer 1964 Sep;17:1108-18. doi: 10.1002/1097-0142(196409)17:9<1108::aid-cncr2820170903>3.0.co;2-8. PMID: 14211782

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