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Bladder diffuse clear cell adenocarcinoma

MedGen UID:
267058
•Concept ID:
C1511187
•
Neoplastic Process
Synonyms: Bladder Diffuse Clear Cell Adenocarcinoma; bladder diffuse clear cell adenocarcinoma
 
Monarch Initiative: MONDO:0003810

Definition

A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a diffuse pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder diffuse clear cell adenocarcinoma

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705

Recent clinical studies

Etiology

Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes.
Khan R, Pari B, Puszynski K
Genes (Basel) 2024 Apr 30;15(5) doi: 10.3390/genes15050577. PMID: 38790205Free PMC Article
'Pseudomesotheliomatous' carcinomas of the pleura: a 10-year analysis of cases from the Environmental Lung Disease Research Group, Cardiff.
Attanoos RL, Gibbs AR
Histopathology 2003 Nov;43(5):444-52. doi: 10.1046/j.1365-2559.2003.01674.x. PMID: 14636270
Clear cell carcinoma of the urinary bladder: a report and comparison of four tumors of mullerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems.
Oliva E, Amin MB, Jimenez R, Young RH
Am J Surg Pathol 2002 Feb;26(2):190-7. doi: 10.1097/00000478-200202000-00005. PMID: 11812940
Nephrogenic adenoma. A report of 15 cases, review of the literature, and comparison with clear cell adenocarcinoma of the urinary tract.
Young RH, Scully RE
Am J Surg Pathol 1986 Apr;10(4):268-75. PMID: 3706613

Diagnosis

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Clinical and pathological characteristics of metastatic tumors to the urinary bladder.
Huang W, Warrick JI, Chen G
Ann Diagn Pathol 2023 Oct;66:152179. Epub 2023 Jul 11 doi: 10.1016/j.anndiagpath.2023.152179. PMID: 37453217
Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma.
Herawi M, Drew PA, Pan CC, Epstein JI
Hum Pathol 2010 Apr;41(4):594-601. Epub 2010 Jan 8 doi: 10.1016/j.humpath.2009.10.011. PMID: 20060152
Clear cell carcinoma of the urinary bladder: a report and comparison of four tumors of mullerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems.
Oliva E, Amin MB, Jimenez R, Young RH
Am J Surg Pathol 2002 Feb;26(2):190-7. doi: 10.1097/00000478-200202000-00005. PMID: 11812940
Clear cell adenocarcinoma of the bladder and urethra. A report of three cases and review of the literature.
Young RH, Scully RE
Am J Surg Pathol 1985 Nov;9(11):816-26. doi: 10.1097/00000478-198511000-00005. PMID: 2416225

Therapy

The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Prognosis

Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes.
Khan R, Pari B, Puszynski K
Genes (Basel) 2024 Apr 30;15(5) doi: 10.3390/genes15050577. PMID: 38790205Free PMC Article
APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA.
Ye B, Shi J, Kang H, Oyebamiji O, Hill D, Yu H, Ness S, Ye F, Ping J, He J, Edwards J, Zhao YY, Guo Y
RNA Biol 2020 Nov;17(11):1666-1673. Epub 2019 Oct 18 doi: 10.1080/15476286.2019.1679585. PMID: 31607216Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations.
Kaplan I, Hodak E, Ackerman L, Mimouni D, Anhalt GJ, Calderon S
Oral Oncol 2004 Jul;40(6):553-62. doi: 10.1016/j.oraloncology.2003.09.020. PMID: 15063382

Clinical prediction guides

Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes.
Khan R, Pari B, Puszynski K
Genes (Basel) 2024 Apr 30;15(5) doi: 10.3390/genes15050577. PMID: 38790205Free PMC Article
APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA.
Ye B, Shi J, Kang H, Oyebamiji O, Hill D, Yu H, Ness S, Ye F, Ping J, He J, Edwards J, Zhao YY, Guo Y
RNA Biol 2020 Nov;17(11):1666-1673. Epub 2019 Oct 18 doi: 10.1080/15476286.2019.1679585. PMID: 31607216Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

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