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Bladder adenocarcinoma

MedGen UID:
76014
•Concept ID:
C0279682
•
Neoplastic Process
Synonyms: Adenocarcinoma of bladder; Adenocarcinoma of Bladder; adenocarcinoma of bladder; Adenocarcinoma of the Bladder; adenocarcinoma of the bladder; Adenocarcinoma of the Urinary Bladder; adenocarcinoma of the urinary bladder; Adenocarcinoma of urinary bladder; Adenocarcinoma of Urinary Bladder; adenocarcinoma of urinary bladder; blad; Bladder Adenocarcinoma; bladder adenocarcinoma; Bladder Adenocarcinoma Excluding Clear Cell Adenocarcinoma and Endometrioid Adenocarcinoma; Bladder Adenocarcinoma NOS; Bladder Adenocarcinoma, NOS; Bladder Adenocarcinoma, Not Otherwise Specified; Urinary Bladder Adenocarcinoma; urinary bladder adenocarcinoma
SNOMED CT: Adenocarcinoma of bladder (255110003); Adenocarcinoma of urinary bladder (255110003)
 
Monarch Initiative: MONDO:0002751

Definition

A rare adenocarcinoma arising from metaplastic bladder epithelium. It is frequently associated with long-standing local irritation. The majority of cases originate from the trigone and the posterior wall of the bladder. This group does not include clear cell and endometrioid adenocarcinomas. [from NCI]

Professional guidelines

PubMed

Facing treatment of non-urothelial bladder cancers in the immunotherapy era.
Grilo I, Rodrigues C, Soares A, Grande E
Crit Rev Oncol Hematol 2020 Sep;153:103034. Epub 2020 Jun 20 doi: 10.1016/j.critrevonc.2020.103034. PMID: 32622321
TRPM8: a potential target for cancer treatment.
Liu Z, Wu H, Wei Z, Wang X, Shen P, Wang S, Wang A, Chen W, Lu Y
J Cancer Res Clin Oncol 2016 Sep;142(9):1871-81. Epub 2016 Jan 23 doi: 10.1007/s00432-015-2112-1. PMID: 26803314
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748

Recent clinical studies

Etiology

Atypical Presentation of Gall Bladder Adenocarcinoma as Paraneoplastic Myeloneuropathy.
Majeed AK, Datta D, Aggarwal D, Panda B, Kumar R
Clin Nucl Med 2024 Nov 1;49(11):e585-e586. Epub 2024 Jul 1 doi: 10.1097/RLU.0000000000005352. PMID: 38968557
Mutational signature and prognosis in adenocarcinoma of the bladder.
Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Identification of SKOR2 IgG as a novel biomarker of paraneoplastic neurologic syndrome.
Rezk M, Pittock SJ, Kapadia RK, Knight AM, Guo Y, Gupta P, LaFrance-Corey RG, Zekeridou A, McKeon A, Dasari S, Mills JR, Dubey D
Front Immunol 2023;14:1243946. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1243946. PMID: 37795104Free PMC Article
Axillary nodal metastasis of operated gallbladder carcinoma: remote site of aggression-a case report.
Vats M, Bains L, Lal P, Mandal S
BMC Surg 2022 Jan 15;22(1):16. doi: 10.1186/s12893-022-01477-3. PMID: 35033032Free PMC Article
Non-urothelial carcinomas of the bladder.
Park S, Reuter VE, Hansel DE
Histopathology 2019 Jan;74(1):97-111. doi: 10.1111/his.13719. PMID: 30565306

Diagnosis

Non-urothelial carcinomas of the bladder.
Park S, Reuter VE, Hansel DE
Histopathology 2019 Jan;74(1):97-111. doi: 10.1111/his.13719. PMID: 30565306
Mimickers of urothelial neoplasia.
Kryvenko ON, Epstein JI
Ann Diagn Pathol 2019 Feb;38:11-19. Epub 2018 Sep 26 doi: 10.1016/j.anndiagpath.2018.09.012. PMID: 30380401
Hepatobiliary and pancreatic: coexisting cancers: Hepatic neuroendocrine carcinomas with gall bladder adenocarcinoma.
Lu J, Xiong XZ, Cheng NS
J Gastroenterol Hepatol 2014;29(7):1343. doi: 10.1111/jgh.12626. PMID: 25040620
Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.
Zhong M, Gersbach E, Rohan SM, Yang XJ
Arch Pathol Lab Med 2013 Mar;137(3):371-81. doi: 10.5858/arpa.2012-0076-RA. PMID: 23451748
Malignant urachal lesions.
Sheldon CA, Clayman RV, Gonzalez R, Williams RD, Fraley EE
J Urol 1984 Jan;131(1):1-8. doi: 10.1016/s0022-5347(17)50167-6. PMID: 6361280

Therapy

Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors.
Apolo AB, Girardi DM, Niglio SA, Nadal R, Kydd AR, Simon N, Ley L, Cordes LM, Chandran E, Steinberg SM, Lee S, Lee MJ, Rastogi S, Sato N, Cao L, Banday AR, Boudjadi S, Merino MJ, Toubaji A, Akbulut D, Redd B, Bagheri H, Costello R, Gurram S, Agarwal PK, Chalfin HJ, Valera V, Streicher H, Wright JJ, Sharon E, Figg WD, Parnes HL, Gulley JL, Saraiya B, Pal SK, Quinn D, Stein MN, Lara PN, Bottaro DP, Mortazavi A
J Clin Oncol 2024 Sep 1;42(25):3033-3046. Epub 2024 Jul 2 doi: 10.1200/JCO.23.02233. PMID: 38954785Free PMC Article
HER-2/neu over expression in gall bladder adenocarcinoma: A quest for potential therapeutic target.
Jain P, Goyal S, Chauhan G, Majumdar K, Ali S, Sakhuja P, Agarwal AK
Indian J Pathol Microbiol 2020 Apr-Jun;63(2):214-220. doi: 10.4103/IJPM.IJPM_664_19. PMID: 32317518
Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee.
Kim MJ, Kim YS, Oh SY, Lee S, Choi YJ, Seol YM, Park MJ, Kim KH, Park LC, Kang JH, Hwang IG, Lee SI, Lim ST, Kim HS, Lim HY, Rha SY, Kim HJ
Korean J Intern Med 2018 Mar;33(2):383-390. Epub 2016 Apr 6 doi: 10.3904/kjim.2015.162. PMID: 27048257Free PMC Article
A Case of Advanced Mucinous Adenocarcinoma of Bladder in an Adult Patient Treated With Capecitabine-Based Chemotherapy and Review of Literature.
Messina C, Dellepiane C, Caroti C, Sarocchi F, Ravetti GL, Boccardo F, Spina B
Clin Genitourin Cancer 2015 Oct;13(5):e365-8. Epub 2015 Apr 15 doi: 10.1016/j.clgc.2015.04.002. PMID: 25935564
Bladder metastasis from lung adenocarcinoma: a difficult differential diagnosis with primary bladder adenocarcinoma.
Cormio L, Sanguedolce F, Di Fino G, Massenio P, Liuzzi G, Bufo P, Carrieri G
World J Surg Oncol 2014 Apr 9;12:90. doi: 10.1186/1477-7819-12-90. PMID: 24716732Free PMC Article

Prognosis

Mutational signature and prognosis in adenocarcinoma of the bladder.
Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Identification of SKOR2 IgG as a novel biomarker of paraneoplastic neurologic syndrome.
Rezk M, Pittock SJ, Kapadia RK, Knight AM, Guo Y, Gupta P, LaFrance-Corey RG, Zekeridou A, McKeon A, Dasari S, Mills JR, Dubey D
Front Immunol 2023;14:1243946. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1243946. PMID: 37795104Free PMC Article
Axillary nodal metastasis of operated gallbladder carcinoma: remote site of aggression-a case report.
Vats M, Bains L, Lal P, Mandal S
BMC Surg 2022 Jan 15;22(1):16. doi: 10.1186/s12893-022-01477-3. PMID: 35033032Free PMC Article
Non-urothelial carcinomas of the bladder.
Park S, Reuter VE, Hansel DE
Histopathology 2019 Jan;74(1):97-111. doi: 10.1111/his.13719. PMID: 30565306
Serotonin and cancer: what is the link?
Sarrouilhe D, Clarhaut J, Defamie N, Mesnil M
Curr Mol Med 2015;15(1):62-77. doi: 10.2174/1566524015666150114113411. PMID: 25601469

Clinical prediction guides

Mutational signature and prognosis in adenocarcinoma of the bladder.
Yang G, Shahatiaili A, Bai S, Wang L, Jin D, Cao M, Su P, Liu Q, Tao K, Long Q, Shi Y, Xiao J, Tian F, Zhang L, Chen H, Su X
J Pathol 2024 Mar;262(3):334-346. Epub 2024 Jan 5 doi: 10.1002/path.6239. PMID: 38180342
Regular gastroscopy and colonoscopy during the evaluation of urachal cancer: do we really need them?
Luo MR, Cai TN, Lu JL, Liu ZH, Guo SJ, Liu ZW, Yao K, Qin ZK, Ye YL
BMC Cancer 2023 Nov 27;23(1):1156. doi: 10.1186/s12885-023-11531-9. PMID: 38012559Free PMC Article
Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype.
Almassi N, Whiting K, Toubaji A, Lenis AT, Jordan EJ, Won H, Regazzi AM, Chen YB, Gopalan A, Sirintrapun SJ, Fine SW, Tickoo SK, Ostrovnaya I, Pietzak EJ, Cha EK, Goh AC, Donahue TF, Herr HW, Donat SM, Dalbagni G, Bochner BH, Teo MY, Funt SA, Rosenberg JE, Reuter VE, Bajorin DF, Solit DB, Al-Ahmadie H, Iyer G
JCO Precis Oncol 2022 Jun;6:e2100392. doi: 10.1200/PO.21.00392. PMID: 35731998Free PMC Article
Pelvic lipomatosis associated with bilateral obstructive uropathy and proliferative cystitis.
Flor JMS, Gaston MJFV, Lapitan MCM
BMJ Case Rep 2021 Aug 17;14(8) doi: 10.1136/bcr-2019-233428. PMID: 34404639Free PMC Article
Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge.
Roy S, Smith MA, Cieply KM, Acquafondata MB, Parwani AV
Diagn Pathol 2012 Nov 2;7:151. doi: 10.1186/1746-1596-7-151. PMID: 23121893Free PMC Article

Recent systematic reviews

Bladder Metastases from Lung Cancer: Clinical and Pathological Implications: A Systematic Review.
Sanguedolce F, Loizzi D, Sollitto F, Di Bisceglie M, Lucarelli G, Carrieri G, Bufo P, Cormio L
Oncology 2017;92(3):125-134. Epub 2017 Jan 6 doi: 10.1159/000454731. PMID: 28056456

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