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Borderline Ovarian Endometrioid Adenofibroma

MedGen UID:
267755
•Concept ID:
C1511262
•
Neoplastic Process

Definition

An epithelial neoplasm that arises from the ovary characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells. The surrounding ovarian stroma is fibrotic. There is no evidence of stromal invasion. [from NCI]

Recent clinical studies

Etiology

TFF3 Expression as Stratification Marker in Borderline Epithelial Tumors of the Ovary.
El-Balat A, Schmeil I, Karn T, Becker S, Sänger N, Holtrich U, Arsenic R
Pathol Oncol Res 2018 Apr;24(2):277-282. Epub 2017 May 3 doi: 10.1007/s12253-017-0240-4. PMID: 28470574
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848
On the histogenesis and morphology of ovarian carcinomas.
Dallenbach-Hellweg G
J Cancer Res Clin Oncol 1984;107(2):71-80. doi: 10.1007/BF00399375. PMID: 6715398
Ovarian endometrioid adenofibromatous and cystadenofibromatous tumors: benign, proliferating, and malignant.
Roth LM, Czernobilsky B, Langley FA
Cancer 1981 Oct 15;48(8):1838-45. doi: 10.1002/1097-0142(19811015)48:8<1838::aid-cncr2820480822>3.0.co;2-r. PMID: 7284979

Diagnosis

Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma.
Miyama Y, Ogasawara A, Hasegawa K, Yasuda M
Int J Gynecol Pathol 2024 Jul 1;43(4):362-372. Epub 2024 Mar 4 doi: 10.1097/PGP.0000000000001002. PMID: 38870078
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Morphological and Immunohistochemical Reevaluation of Tumors Initially Diagnosed as Ovarian Endometrioid Carcinoma With Emphasis on High-grade Tumors.
Lim D, Murali R, Murray MP, Veras E, Park KJ, Soslow RA
Am J Surg Pathol 2016 Mar;40(3):302-12. doi: 10.1097/PAS.0000000000000550. PMID: 26551621Free PMC Article
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826

Therapy

Benign, borderline, and malignant endometrioid neoplasia arising in endometriosis in association with tamoxifen therapy.
McCluggage WG, Bryson C, Lamki H, Boyle DD
Int J Gynecol Pathol 2000 Jul;19(3):276-9. doi: 10.1097/00004347-200007000-00013. PMID: 10907178
Ovarian endometrioid adenocarcinoma coexistent with benign and borderline endometrioid adenofibroma: a case report.
Ushijima K, Nishida T, Muraoka Y, Sugiyama T, Okura N, Shinagawa A, Imaishi K, Yakushiji M
J Obstet Gynaecol Res 1998 Apr;24(2):161-6. doi: 10.1111/j.1447-0756.1998.tb00069.x. PMID: 9631607

Prognosis

Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma.
Miyama Y, Ogasawara A, Hasegawa K, Yasuda M
Int J Gynecol Pathol 2024 Jul 1;43(4):362-372. Epub 2024 Mar 4 doi: 10.1097/PGP.0000000000001002. PMID: 38870078
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Morphological and Immunohistochemical Reevaluation of Tumors Initially Diagnosed as Ovarian Endometrioid Carcinoma With Emphasis on High-grade Tumors.
Lim D, Murali R, Murray MP, Veras E, Park KJ, Soslow RA
Am J Surg Pathol 2016 Mar;40(3):302-12. doi: 10.1097/PAS.0000000000000550. PMID: 26551621Free PMC Article
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Atypical and borderline endometrioid adenofibromas of the ovary. A report of 27 cases.
Bell DA, Scully RE
Am J Surg Pathol 1985 Mar;9(3):205-14. doi: 10.1097/00000478-198503000-00004. PMID: 3993832

Clinical prediction guides

Premature Classification of Early-stage Endometrioid Ovarian Carcinoma With Mesonephric-like Differentiation as Mesonephric-like Adenocarcinoma.
Miyama Y, Ogasawara A, Hasegawa K, Yasuda M
Int J Gynecol Pathol 2024 Jul 1;43(4):362-372. Epub 2024 Mar 4 doi: 10.1097/PGP.0000000000001002. PMID: 38870078
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Morphological and Immunohistochemical Reevaluation of Tumors Initially Diagnosed as Ovarian Endometrioid Carcinoma With Emphasis on High-grade Tumors.
Lim D, Murali R, Murray MP, Veras E, Park KJ, Soslow RA
Am J Surg Pathol 2016 Mar;40(3):302-12. doi: 10.1097/PAS.0000000000000550. PMID: 26551621Free PMC Article
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848

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