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Female Reproductive System Precancerous Condition

MedGen UID:
272628
•Concept ID:
C1333604
•
Disease or Syndrome

Definition

A precancerous lesion that arises from the female reproductive system. Representative examples include atypical endometrial hyperplasia, endometrial intraepithelial neoplasia, and cervical intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale Reproductive System Precancerous Condition

Professional guidelines

PubMed

The significance of HPV L1 and Ki-67 detection in cervical intraepithelial neoplasm screening.
Luo Y, Cai M, Shen P, Chen H, Yao J
Minerva Med 2019 Dec;110(6):586-587. Epub 2019 Jul 9 doi: 10.23736/S0026-4806.19.05916-0. PMID: 31295980
High-grade cervical dysplasia: pathophysiology, diagnosis, and treatment.
Zsemlye M
Obstet Gynecol Clin North Am 2008 Dec;35(4):615-21; ix. doi: 10.1016/j.ogc.2008.09.008. PMID: 19061820
Current concepts in obstetrics and gynecology: The patient with an abnormal Pap smear--screening techniques and management.
Richart RM
N Engl J Med 1980 Feb 7;302(6):332-4. doi: 10.1056/NEJM198002073020606. PMID: 6985710

Recent clinical studies

Etiology

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Endometrial Carcinoma and its Precursors.
Javadian P, Nezhat F
Adv Exp Med Biol 2020;1242:59-72. doi: 10.1007/978-3-030-38474-6_4. PMID: 32406028
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article

Diagnosis

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva.
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
The Origin of Ovarian Cancer Species and Precancerous Landscape.
Shih IM, Wang Y, Wang TL
Am J Pathol 2021 Jan;191(1):26-39. Epub 2020 Oct 1 doi: 10.1016/j.ajpath.2020.09.006. PMID: 33011111Free PMC Article
Endometrial Carcinoma and its Precursors.
Javadian P, Nezhat F
Adv Exp Med Biol 2020;1242:59-72. doi: 10.1007/978-3-030-38474-6_4. PMID: 32406028
Vulval squamous cell carcinoma and its precursors.
Singh N, Gilks CB
Histopathology 2020 Jan;76(1):128-138. doi: 10.1111/his.13989. PMID: 31846523
The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article

Therapy

Cervicovaginal microbiome, high-risk HPV infection and cervical cancer: Mechanisms and therapeutic potential.
Huang R, Liu Z, Sun T, Zhu L
Microbiol Res 2024 Oct;287:127857. Epub 2024 Jul 26 doi: 10.1016/j.micres.2024.127857. PMID: 39121703
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses.
Arbyn M, Smith SB, Temin S, Sultana F, Castle P; Collaboration on Self-Sampling and HPV Testing
BMJ 2018 Dec 5;363:k4823. doi: 10.1136/bmj.k4823. PMID: 30518635Free PMC Article
Fertility-preserving surgical procedures for patients with gynecologic malignancies.
Rasool N, Rose PG
Clin Obstet Gynecol 2010 Dec;53(4):804-14. doi: 10.1097/GRF.0b013e3181f97d02. PMID: 21048447

Prognosis

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Cervicovaginal microbiome and natural history of HPV in a longitudinal study.
Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, Gonzalez P, Safaeian M, Schiffman M, Burk RD; Costa Rica HPV Vaccine Trial (CVT) Group
PLoS Pathog 2020 Mar;16(3):e1008376. Epub 2020 Mar 26 doi: 10.1371/journal.ppat.1008376. PMID: 32214382Free PMC Article
The importance of cryosurgery in gynecological practice.
Wojciech R
Ginekol Pol 2011 Aug;82(8):618-22. PMID: 21957608
Reid's Colposcopic Index.
Ferris DG, Greenberg MD
J Fam Pract 1994 Jul;39(1):65-70. PMID: 7517993
Cervical intraepithelial neoplasia.
Richart RM
Pathol Annu 1973;8:301-28. PMID: 4583016

Clinical prediction guides

Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer.
Zhang T, Zhuang L, Muaibati M, Wang D, Abasi A, Tong Q, Ma D, Jin L, Huang X
EBioMedicine 2023 Jun;92:104612. Epub 2023 May 22 doi: 10.1016/j.ebiom.2023.104612. PMID: 37224771Free PMC Article
Management of ASC-US/HPV positive post-menopausal woman.
Bruno MT, Coco A, Di Pasqua S, Bonanno G
Virol J 2019 Mar 28;16(1):39. doi: 10.1186/s12985-019-1145-5. PMID: 30922353Free PMC Article
Malignant transformation of endometriosis and its clinical significance.
Nezhat F, Apostol R, Mahmoud M, el Daouk M
Fertil Steril 2014 Aug;102(2):342-4. Epub 2014 May 28 doi: 10.1016/j.fertnstert.2014.04.050. PMID: 24880652
The importance of cryosurgery in gynecological practice.
Wojciech R
Ginekol Pol 2011 Aug;82(8):618-22. PMID: 21957608
Reid's Colposcopic Index.
Ferris DG, Greenberg MD
J Fam Pract 1994 Jul;39(1):65-70. PMID: 7517993

Recent systematic reviews

A systematic review of laser therapy for vulvar skin conditions.
Kim K, Desai M, Elsensohn A, Kraus CN
J Am Acad Dermatol 2023 May;88(5):1200-1201. Epub 2023 Jan 11 doi: 10.1016/j.jaad.2023.01.003. PMID: 36639033
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N
BJOG 2020 Jan;127(2):171-180. Epub 2019 Jul 17 doi: 10.1111/1471-0528.15854. PMID: 31237400
Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis.
Kyrgiou M, Athanasiou A, Paraskevaidi M, Mitra A, Kalliala I, Martin-Hirsch P, Arbyn M, Bennett P, Paraskevaidis E
BMJ 2016 Jul 28;354:i3633. doi: 10.1136/bmj.i3633. PMID: 27469988Free PMC Article
Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis.
Ebisch RM, Rovers MM, Bosgraaf RP, van der Pluijm-Schouten HW, Melchers WJ, van den Akker PA, Massuger LF, Bekkers RL
BJOG 2016 Jan;123(1):59-66. Epub 2015 Jul 14 doi: 10.1111/1471-0528.13530. PMID: 26177672

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