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AIDS-Related Malignant Anal Neoplasm

MedGen UID:
272258
•Concept ID:
C1332049
•
Neoplastic Process
Synonyms: AIDS-Related Malignant Anal Tumor; AIDS-Related Malignant Neoplasm of Anus; AIDS-Related Malignant Neoplasm of the Anus; AIDS-Related Malignant Tumor of Anus; AIDS-Related Malignant Tumor of the Anus

Definition

A malignant neoplasm arising from the anus and occurring in HIV-positive patients. Representative examples include squamous cell carcinoma and non-Hodgkin lymphoma. Homosexual HIV-positive men have an increased risk of developing such malignancies in comparison to the general male population. [from NCI]

Professional guidelines

PubMed

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399

Recent clinical studies

Etiology

Moving forward in HIV-associated cancer.
Gopal S, Achenbach CJ, Yanik EL, Dittmer DP, Eron JJ, Engels EA
J Clin Oncol 2014 Mar 20;32(9):876-80. Epub 2014 Feb 18 doi: 10.1200/JCO.2013.53.1376. PMID: 24550416Free PMC Article
Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399
Opportunistic infections.
Vazquez E
Posit Aware 1996 Sep-Oct;7(5):12-3. PMID: 11363782
AIDS-associated malignancies.
Krown SE
Cancer Chemother Biol Response Modif 1996;16:441-61. PMID: 8639393

Diagnosis

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Diagnosis and management of HPV-related anal dysplasia.
Greene MD
Nurse Pract 2009 May;34(5):45-51. doi: 10.1097/01.NPR.0000350571.53729.74. PMID: 19390399
Opportunistic infections.
Vazquez E
Posit Aware 1996 Sep-Oct;7(5):12-3. PMID: 11363782
AIDS-associated malignancies.
Krown SE
Cancer Chemother Biol Response Modif 1996;16:441-61. PMID: 8639393

Therapy

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Diagnosis and management of lymphomas and other cancers in HIV-infected patients.
Carbone A, Vaccher E, Gloghini A, Pantanowitz L, Abayomi A, de Paoli P, Franceschi S
Nat Rev Clin Oncol 2014 Apr;11(4):223-38. Epub 2014 Mar 11 doi: 10.1038/nrclinonc.2014.31. PMID: 24614140
Moving forward in HIV-associated cancer.
Gopal S, Achenbach CJ, Yanik EL, Dittmer DP, Eron JJ, Engels EA
J Clin Oncol 2014 Mar 20;32(9):876-80. Epub 2014 Feb 18 doi: 10.1200/JCO.2013.53.1376. PMID: 24550416Free PMC Article
Novel treatment of atypical human papillomavirus-associated epithelial hyperplasia with cidofovir.
Collette DC, Zechel MA
J Oral Maxillofac Surg 2011 Sep;69(9):2383-6. Epub 2011 Feb 3 doi: 10.1016/j.joms.2010.10.040. PMID: 21292369
Cancer and HIV infection.
Cottrill CP, Bottomley DM, Phillips RH
Clin Oncol (R Coll Radiol) 1997;9(6):365-80. doi: 10.1016/s0936-6555(97)80129-x. PMID: 9448965

Prognosis

Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.
Kan M, Wong PH, Press N, Wiseman SM
Expert Rev Anticancer Ther 2014 Apr;14(4):395-405. Epub 2014 Feb 9 doi: 10.1586/14737140.2013.877843. PMID: 24506785
Human papillomavirus, anal cancer, and screening considerations among HIV-infected individuals.
Cachay ER, Mathews WC
AIDS Rev 2013 Apr-Jun;15(2):122-33. PMID: 23681437
Novel treatment of atypical human papillomavirus-associated epithelial hyperplasia with cidofovir.
Collette DC, Zechel MA
J Oral Maxillofac Surg 2011 Sep;69(9):2383-6. Epub 2011 Feb 3 doi: 10.1016/j.joms.2010.10.040. PMID: 21292369
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
AIDS-associated malignancies.
Krown SE
Cancer Chemother Biol Response Modif 1996;16:441-61. PMID: 8639393

Clinical prediction guides

Non-AIDS-Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.
Zucchetto A, Virdone S, Taborelli M, Grande E, Camoni L, Pappagallo M, Regine V, Grippo F, Polesel J, Dal Maso L, Suligoi B, Frova L, Serraino D
J Acquir Immune Defic Syndr 2016 Oct 1;73(2):190-6. doi: 10.1097/QAI.0000000000001033. PMID: 27116048
Survival after cancer in Italian persons with AIDS, 1986-2005: a population-based estimation.
Dal Maso L, Suligoi B, Franceschi S, Braga C, Buzzoni C, Polesel J, Zucchetto A, Piselli P, Falcini F, Caldarella A, Zanetti R, Vercelli M, Guzzinati S, Russo A, Tagliabue G, Iachetta F, Ferretti S, Limina RM, Mangone L, Michiara M, Stracci F, Pirino DR, Piffer S, Giacomin A, Vitarelli S, Mazzoleni G, Iannelli A, Contrino ML, Fusco M, Tumino R, Fanetti AC, De Paoli P, Decarli A, Serraino D; Cancer and AIDS Registries Linkage Study
J Acquir Immune Defic Syndr 2014 Aug 1;66(4):428-35. doi: 10.1097/QAI.0000000000000184. PMID: 24798769
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA
Int J STD AIDS 2007 Feb;18(2):77-80. doi: 10.1258/095646207779949772. PMID: 17331275
Anal intraepithelial neoplasia in HIV positive people.
Martin F, Bower M
Sex Transm Infect 2001 Oct;77(5):327-31. doi: 10.1136/sti.77.5.327. PMID: 11588276Free PMC Article
Acquired immunodeficiency syndrome-associated cancers in Sub-Saharan Africa.
Thomas JO
Semin Oncol 2001 Apr;28(2):198-206. doi: 10.1016/s0093-7754(01)90092-2. PMID: 11301383

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