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Childhood Testicular Yolk Sac Tumor

MedGen UID:
272473
•Concept ID:
C1333012
•
Neoplastic Process
Synonyms: Childhood Testicular Endodermal Sinus Neoplasm; Childhood Testicular Endodermal Sinus Tumor; Childhood Testicular Yolk Sac Neoplasm; Pediatric Testicular Endodermal Sinus Neoplasm; Pediatric Testicular Endodermal Sinus Tumor; Pediatric Testicular Yolk Sac Neoplasm; Pediatric Testicular Yolk Sac Tumor

Definition

A yolk sac tumor that arises from the testis during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Testicular Yolk Sac Tumor

Professional guidelines

PubMed

Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis.
Hou JY, Liu HC, Yeh TC, Sheu JC, Chen KH, Chang CY, Liang DC
Pediatr Neonatol 2015 Oct;56(5):301-6. Epub 2015 Feb 2 doi: 10.1016/j.pedneo.2014.12.003. PMID: 25769700
Testicular germ cell tumors in childhood: treatment results of 52 patients.
Güler E, Tezer Kutluk M, Büyükpamukçu N, Caglar M, Varan A, Akyüz C, Büyükpamukçu M
Pediatr Hematol Oncol 2004 Jan-Feb;21(1):49-56. PMID: 14660306
Conservative management of testicular endodermal sinus tumor in childhood.
Carroll WL, Kempson RL, Govan DE, Freiha FS, Shochat SJ, Link MP
J Urol 1985 Jun;133(6):1011-4. doi: 10.1016/s0022-5347(17)49354-2. PMID: 2582151

Recent clinical studies

Etiology

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Cytodiagnosis of yolk sac tumor.
Afroz N, Khan N, Chana RS
Indian J Pediatr 2004 Oct;71(10):939-42. doi: 10.1007/BF02830842. PMID: 15531841

Diagnosis

Unusual Presentation, Relapse, and Metastasis of a Pediatric Testicular Yolk Sac Tumor: Case Report.
Alshamsi H, Sarhan OM, Almatar A, Ali BA, Boqari D, Kawai FA
Urology 2021 Mar;149:e40-e43. Epub 2020 Oct 24 doi: 10.1016/j.urology.2020.10.014. PMID: 33141029
Sonographic appearance of a testicular yolk sac tumor in a 2-year-old boy.
Xu HX, Yi XP
J Clin Ultrasound 2007 Jan;35(1):55-7. doi: 10.1002/jcu.20249. PMID: 16960883
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Cytodiagnosis of yolk sac tumor.
Afroz N, Khan N, Chana RS
Indian J Pediatr 2004 Oct;71(10):939-42. doi: 10.1007/BF02830842. PMID: 15531841
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

Therapy

Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis.
Hou JY, Liu HC, Yeh TC, Sheu JC, Chen KH, Chang CY, Liang DC
Pediatr Neonatol 2015 Oct;56(5):301-6. Epub 2015 Feb 2 doi: 10.1016/j.pedneo.2014.12.003. PMID: 25769700
The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol.
Göbel U, Calaminus G, Schneider DT, Koch S, Teske C, Harms D
Klin Padiatr 2006 Nov-Dec;218(6):309-14. doi: 10.1055/s-2006-942275. PMID: 17080332
Teratomas in infancy and childhood.
Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP, Hass RJ, Waag K, Blohm ME, Dippert S, Teske C, Harms D
Med Pediatr Oncol 1998 Jul;31(1):8-15. doi: 10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID: 9607423
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
Göbel U, Calaminus G, Blohm M, Booss D, Felberbauer F, Hofmann U, Holschneider AM, Willnow U, Harms D
Klin Padiatr 1997 Jul-Aug;209(4):228-34. doi: 10.1055/s-2008-1043955. PMID: 9293455
Primary testicular tumors in children.
Lin JN, Wang KL, Chuang JH
Int Surg 1988 Jul-Sep;73(3):190-2. PMID: 2466012

Prognosis

Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
New concepts in the treatment of genitourinary cancer in childhood.
Walker RD
Semin Surg Oncol 1989;5(4):227-34. doi: 10.1002/ssu.2980050404. PMID: 2672229
Testicular tumours in children.
Livingstone RR, Sarembock LA
S Afr Med J 1986 Aug 2;70(3):168-9. PMID: 3461569
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Pediatric germ cell tumors presenting beyond childhood?
Oosterhuis JW, Stoop JA, Rijlaarsdam MA, Biermann K, Smit VT, Hersmus R, Looijenga LH
Andrology 2015 Jan;3(1):70-7. Epub 2014 Nov 27 doi: 10.1111/andr.305. PMID: 25427839
Teratomas in infancy and childhood.
Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP, Hass RJ, Waag K, Blohm ME, Dippert S, Teske C, Harms D
Med Pediatr Oncol 1998 Jul;31(1):8-15. doi: 10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID: 9607423
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
Göbel U, Calaminus G, Blohm M, Booss D, Felberbauer F, Hofmann U, Holschneider AM, Willnow U, Harms D
Klin Padiatr 1997 Jul-Aug;209(4):228-34. doi: 10.1055/s-2008-1043955. PMID: 9293455
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

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