Childhood germ cell tumor

MedGen UID:: 75907
•Concept ID:: C0279014
•: Neoplastic Process

Synonyms:	Childhood Germ Cell Neoplasm; childhood germ cell neoplasm; Childhood Germ Cell Tumor; childhood germ cell tumor; paediatric germ cell cancer; paediatric germ cell neoplasm; paediatric germ cell tumour; pediatric germ cell cancer; Pediatric Germ Cell Neoplasm; pediatric germ cell neoplasm; Pediatric Germ Cell Tumor; pediatric germ cell tumor

Monarch Initiative:	MONDO:0003751

Definition

A germ cell tumor that occurs during childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChildhood germ cell tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Childhood neoplasm
        Childhood germ cell tumor
        Childhood Benign Germ Cell Tumor
        Childhood Mature Teratoma
        Childhood central nervous system mature teratoma
        Childhood mature teratoma of the ovary
        Childhood Testicular Mature Teratoma
        Childhood central nervous system germ cell tumor
        Central nervous system endodermal sinus tumor
        Childhood central nervous system embryonal carcinoma
        Childhood central nervous system germinoma
        Childhood brain germinoma
        Childhood central nervous system mixed germ cell tumor
        Childhood Central Nervous System Teratoma
        Childhood central nervous system immature teratoma
        Childhood germ cell brain tumor
        Pediatric CNS choriocarcinoma
        Childhood Extracranial Germ Cell Tumor
        Childhood gonadal germ cell tumor
        Childhood testicular germ cell tumor
        Pediatric ovarian germ cell tumor
        Childhood Germinomatous Germ Cell Tumor
        Childhood Seminoma
        Pediatric ovarian dysgerminoma
        Childhood Nongerminomatous Germ Cell Tumor
        Childhood Choriocarcinoma
        Childhood choriocarcinoma of the ovary
        Childhood testicular choriocarcinoma
        Childhood Embryonal Carcinoma
        Childhood embryonal testis carcinoma
        Childhood ovarian embryonal carcinoma
        Childhood endodermal sinus tumor
        Childhood ovarian yolk sac tumor
        Childhood Testicular Yolk Sac Tumor
        Childhood Ovarian Nongerminomatous Germ Cell Tumor
        Childhood teratoma of the ovary
        Childhood Teratoma
        Childhood Immature Teratoma
        Childhood Testicular Teratoma
        Childhood Testicular Non-Seminomatous Germ Cell Tumor
        Childhood testicular mixed embryonal carcinoma and teratoma
        Malignant childhood germ cell neoplasm
        Childhood Extragonadal Malignant Germ Cell Tumor
        Childhood Malignant Ovarian Germ Cell Tumor
        Childhood Ovarian Mixed Germ Cell Tumor
        Childhood Malignant Testicular Germ Cell Tumor
        Childhood testicular mixed germ cell cancer
        Childhood Mixed Germ Cell Tumor
        Recurrent Childhood Malignant Germ Cell Tumor
        Refractory Childhood Malignant Germ Cell Tumor

Professional guidelines

PubMed

National UK guidelines for the management of paediatric craniopharyngioma.

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682

Modern treatment of retinoblastoma: A 2020 review.

Ancona-Lezama D, Dalvin LA, Shields CL
Indian J Ophthalmol 2020 Nov;68(11):2356-2365. doi: 10.4103/ijo.IJO_721_20. PMID: 33120616 Free PMC Article

Updates in Diagnosis, Management, and Treatment of Neuroblastoma.

Swift CC, Eklund MJ, Kraveka JM, Alazraki AL
Radiographics 2018 Mar-Apr;38(2):566-580. doi: 10.1148/rg.2018170132. PMID: 29528815

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Recent clinical studies

Etiology

Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors.

Lengert AVH, Pereira LDNB, Cabral ERM, Gomes INF, Jesus LM, Gonçalves MFS, Rocha AOD, Tassinari TA, Silva LSD, Laus AC, Vidal DO, Pinto MT, Reis RM, Lopes LF
Front Biosci (Landmark Ed) 2022 Aug 16;27(8):245. doi: 10.31083/j.fbl2708245. PMID: 36042160

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Diagnosis

Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures.

Santarosa Vieira AG, da Silva LS, Albino da Silva EC, Laus AC, Faria TMV, van Helvoort Lengert A, Martins GE, de Oliveira MA, Reis RM, Lopes LF, Pinto MT
Mol Oncol 2024 Jun;18(6):1593-1607. Epub 2024 May 9 doi: 10.1002/1878-0261.13617. PMID: 38725152 Free PMC Article

Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors.

See all (2)