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Human Papillomavirus-Related Vulvar Squamous Cell Carcinoma

MedGen UID:
272727
•Concept ID:
C1334059
•
Neoplastic Process
Synonyms: HPV-Related Vulvar Squamous Cell Carcinoma; Human Papilloma Virus Related Vulvar Squamous Cell Carcinoma; Human Papilloma Virus-Related Vulvar Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the vulva and is caused by human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman Papillomavirus-Related Vulvar Squamous Cell Carcinoma

Professional guidelines

PubMed

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review.
Pham CT, Juhasz M, Sung CT, Mesinkovska NA
J Am Acad Dermatol 2020 Jan;82(1):202-212. Epub 2019 May 11 doi: 10.1016/j.jaad.2019.04.067. PMID: 31085272

Recent clinical studies

Etiology

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies.
Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM
Head Neck 2014 Jun;36(6):819-25. Epub 2013 Sep 2 doi: 10.1002/hed.23379. PMID: 23720126
Incidence of potentially human papillomavirus-related neoplasms in the United States, 1978 to 2007.
Kurdgelashvili G, Dores GM, Srour SA, Chaturvedi AK, Huycke MM, Devesa SS
Cancer 2013 Jun 15;119(12):2291-9. Epub 2013 Apr 11 doi: 10.1002/cncr.27989. PMID: 23580435Free PMC Article
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720
(Pre)malignancies of the female anogenital tract in renal transplant recipients.
Meeuwis KA, van Rossum MM, Hoitsma AJ, de Hullu JA
Transplantation 2011 Jan 15;91(1):8-10. doi: 10.1097/tp.0b013e3181fbd008. PMID: 21452406

Diagnosis

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Postpartum regression of human papillomavirus-related vulvar cancer: A case report.
Murakami M, Taniguchi S, Murakami T, Imamura H, Marutsuka K, Shimamoto T
J Obstet Gynaecol Res 2022 Nov;48(11):2982-2987. Epub 2022 Aug 16 doi: 10.1111/jog.15389. PMID: 35975323
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720
(Pre)malignancies of the female anogenital tract in renal transplant recipients.
Meeuwis KA, van Rossum MM, Hoitsma AJ, de Hullu JA
Transplantation 2011 Jan 15;91(1):8-10. doi: 10.1097/tp.0b013e3181fbd008. PMID: 21452406
Extensive human papillomavirus-related disease (bowenoid papulosis, Bowen's disease, and squamous cell carcinoma) in a patient with hairy cell leukemia: clinical and immunologic evaluation after an interferon alfa trial.
Lebbe C, Rybojad M, Ochonisky S, Miclea JM, Verola O, Cordoliani F, Ablon G, Morel P
J Am Acad Dermatol 1993 Oct;29(4):644-6. doi: 10.1016/s0190-9622(08)81872-5. PMID: 8408802

Therapy

The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review.
Pham CT, Juhasz M, Sung CT, Mesinkovska NA
J Am Acad Dermatol 2020 Jan;82(1):202-212. Epub 2019 May 11 doi: 10.1016/j.jaad.2019.04.067. PMID: 31085272
(Pre)malignancies of the female anogenital tract in renal transplant recipients.
Meeuwis KA, van Rossum MM, Hoitsma AJ, de Hullu JA
Transplantation 2011 Jan 15;91(1):8-10. doi: 10.1097/tp.0b013e3181fbd008. PMID: 21452406
Genetic aberrations detected by comparative genomic hybridisation in vulvar cancers.
Allen DG, Hutchins AM, Hammet F, White DJ, Scurry JP, Tabrizi SN, Garland SM, Armes JE
Br J Cancer 2002 Mar 18;86(6):924-8. doi: 10.1038/sj.bjc.6600112. PMID: 11953825Free PMC Article
Extensive human papillomavirus-related disease (bowenoid papulosis, Bowen's disease, and squamous cell carcinoma) in a patient with hairy cell leukemia: clinical and immunologic evaluation after an interferon alfa trial.
Lebbe C, Rybojad M, Ochonisky S, Miclea JM, Verola O, Cordoliani F, Ablon G, Morel P
J Am Acad Dermatol 1993 Oct;29(4):644-6. doi: 10.1016/s0190-9622(08)81872-5. PMID: 8408802

Prognosis

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies.
Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM
Head Neck 2014 Jun;36(6):819-25. Epub 2013 Sep 2 doi: 10.1002/hed.23379. PMID: 23720126
Epithelial-mesenchymal transition-like events in vulvar cancer and its relation with HPV.
Rodrigues IS, Lavorato-Rocha AM, de M Maia B, Stiepcich MM, de Carvalho FM, Baiocchi G, Soares FA, Rocha RM
Br J Cancer 2013 Jul 9;109(1):184-94. Epub 2013 Jun 18 doi: 10.1038/bjc.2013.273. PMID: 23778524Free PMC Article
Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia.
Pinto AP, Degen M, Barron P, Crum CP, Rheinwald JG
Mod Pathol 2013 Nov;26(11):1498-507. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.85. PMID: 23765247
Prognostic significance of epithelial disorders adjacent to invasive vulvar carcinomas.
Rouzier R, Morice P, Haie-Meder C, Lhomme C, Avril MF, Duvillard P, Castaigne D
Gynecol Oncol 2001 Jun;81(3):414-9. doi: 10.1006/gyno.2001.6198. PMID: 11371131

Clinical prediction guides

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients.
Watson CH, Spinosa D, Hayes T, Scott A, Jackson L, Thacker JK, Sherman KL, Moss HA, Havrilesky LJ, McNally JL
J Low Genit Tract Dis 2023 Apr 1;27(2):120-124. Epub 2023 Feb 3 doi: 10.1097/LGT.0000000000000723. PMID: 36745862
Postpartum regression of human papillomavirus-related vulvar cancer: A case report.
Murakami M, Taniguchi S, Murakami T, Imamura H, Marutsuka K, Shimamoto T
J Obstet Gynaecol Res 2022 Nov;48(11):2982-2987. Epub 2022 Aug 16 doi: 10.1111/jog.15389. PMID: 35975323
Epithelial-mesenchymal transition-like events in vulvar cancer and its relation with HPV.
Rodrigues IS, Lavorato-Rocha AM, de M Maia B, Stiepcich MM, de Carvalho FM, Baiocchi G, Soares FA, Rocha RM
Br J Cancer 2013 Jul 9;109(1):184-94. Epub 2013 Jun 18 doi: 10.1038/bjc.2013.273. PMID: 23778524Free PMC Article
Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia.
Pinto AP, Degen M, Barron P, Crum CP, Rheinwald JG
Mod Pathol 2013 Nov;26(11):1498-507. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.85. PMID: 23765247

Recent systematic reviews

The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review.
Pham CT, Juhasz M, Sung CT, Mesinkovska NA
J Am Acad Dermatol 2020 Jan;82(1):202-212. Epub 2019 May 11 doi: 10.1016/j.jaad.2019.04.067. PMID: 31085272

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