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Vulvar inverted follicular keratosis

MedGen UID:
274414
•Concept ID:
C1520084
•
Neoplastic Process
Synonyms: inverted follicular keratosis of mammalian vulva; mammalian vulva inverted follicular keratosis; Vulvar Inverted Follicular Keratosis; vulvar inverted follicular keratosis
 
Monarch Initiative: MONDO:0006621

Definition

Seborrheic keratosis that arises from follicular structures in the vulva. It is characterized by the presence of prominent squamous eddies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar inverted follicular keratosis

Recent clinical studies

Etiology

HPV42-associated Seborrhoeic Keratosis-like Lesion of the Cervix: First Reported Case With High-grade Morphology.
Talia KL, Rahimi S, Hawkes D, McCluggage WG
Int J Gynecol Pathol 2022 Nov 1;41(6):649-654. Epub 2021 Nov 12 doi: 10.1097/PGP.0000000000000835. PMID: 35072991
Vulvar seborrheic keratosis: is there a relationship to human papillomavirus?
Reutter JC, Geisinger KR, Laudadio J
J Low Genit Tract Dis 2014 Apr;18(2):190-4. doi: 10.1097/LGT.0b013e3182952357. PMID: 24556611
Pigmented lesions of the vulva.
Venkatesan A
Dermatol Clin 2010 Oct;28(4):795-805. doi: 10.1016/j.det.2010.08.007. PMID: 20883921
Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis.
Bai H, Cviko A, Granter S, Yuan L, Betensky RA, Crum CP
Hum Pathol 2003 Jun;34(6):559-64. doi: 10.1016/s0046-8177(03)00184-9. PMID: 12827609
Non-ulcerative basal cell carcinoma arising on the genitalia.
Takahashi H
J Dermatol 2000 Dec;27(12):798-801. doi: 10.1111/j.1346-8138.2000.tb02285.x. PMID: 11211798

Diagnosis

Urologic Dermatology: a Review.
Stamm AW, Kobashi KC, Stefanovic KB
Curr Urol Rep 2017 Aug;18(8):62. doi: 10.1007/s11934-017-0712-9. PMID: 28667573
Benign Tumors and Tumor-like Lesions of the Vulva.
Heller DS
Clin Obstet Gynecol 2015 Sep;58(3):526-35. doi: 10.1097/GRF.0000000000000133. PMID: 26125957
Pigmented vulvar lesions.
Edwards L
Dermatol Ther 2010 Sep-Oct;23(5):449-57. doi: 10.1111/j.1529-8019.2010.01349.x. PMID: 20868400
Vulvar seborrheic keratosis.
Shier RM, Rasty G
J Obstet Gynaecol Can 2007 Dec;29(12):967. doi: 10.1016/S1701-2163(16)32695-0. PMID: 18053380
Vulvar melanoma.
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827

Prognosis

Non-ulcerative basal cell carcinoma arising on the genitalia.
Takahashi H
J Dermatol 2000 Dec;27(12):798-801. doi: 10.1111/j.1346-8138.2000.tb02285.x. PMID: 11211798
Vulvar melanoma.
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827

Clinical prediction guides

Dermoscopic and clinical features of pigmented skin lesions of the genital area.
Cengiz FP, Emiroglu N, Wellenhof RH
An Bras Dermatol 2015 Mar-Apr;90(2):178-83. doi: 10.1590/abd1806-4841.20153294. PMID: 25830986Free PMC Article
Vulvar melanocytic nevi: a dermoscopic investigation.
Virgili A, Zampino MR, Marzola A, Corazza M
Dermatology 2010 Aug;221(1):55-62. Epub 2010 May 13 doi: 10.1159/000278259. PMID: 20484874
Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma.
Roth LM, Look KY
Int J Gynecol Pathol 2000 Oct;19(4):369-73. doi: 10.1097/00004347-200010000-00012. PMID: 11109167

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