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Inverted follicular keratosis

MedGen UID:
87190
•Concept ID:
C0334019
•
Neoplastic Process
Synonyms: inverted folicular keratosis; Inverted Follicular Keratosis; inverted follicular keratosis; Inverted keratosis
SNOMED CT: Inverted follicular keratosis (394728005); Inverted keratosis (15112009); Inverted follicular keratosis (15112009)
 
Monarch Initiative: MONDO:0006563

Definition

Seborrheic keratosis that arises from follicular structures in the skin. It presents as a solitary nodule in the skin and is characterized by the presence of prominent squamous eddies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInverted follicular keratosis

Professional guidelines

PubMed

Dermoscopy in Primary Care.
Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161
Lentigo maligna: diagnosis and treatment.
De Luca EV, Perino F, Di Stefani A, Coco V, Fossati B, Peris K
G Ital Dermatol Venereol 2020 Apr;155(2):179-189. Epub 2018 Apr 19 doi: 10.23736/S0392-0488.18.06003-0. PMID: 29683288
Paraneoplastic Itch Management.
Rowe B, Yosipovitch G
Curr Probl Dermatol 2016;50:149-54. Epub 2016 Aug 23 doi: 10.1159/000446060. PMID: 27578084

Recent clinical studies

Etiology

Dermatoscopic profiling of inverted follicular keratosis in different skin phenotypes.
Demirdağ HG, Akay BN
Clin Exp Dermatol 2024 Aug 22;49(9):984-990. doi: 10.1093/ced/llae008. PMID: 38183679
Periocular inverted follicular keratosis: a retrospective series over 17 years.
Díez-Montero C, González González D, Pérez Martínez E, Schellini S, Galindo-Ferreiro A
Jpn J Ophthalmol 2019 Mar;63(2):210-214. Epub 2019 Jan 2 doi: 10.1007/s10384-018-00650-7. PMID: 30604112
Cutaneous Horn of the Eyelid in 13 Cases.
Pointdujour-Lim R, Marous MR, Satija CE, Douglass AM, Eagle RC Jr, Shields JA, Shields CL
Ophthalmic Plast Reconstr Surg 2017 Jul/Aug;33(4):233-236. doi: 10.1097/IOP.0000000000000816. PMID: 27811637
Inverted follicular keratosis of the nasal vestibule.
Villaret AB, Gily B, Aga A
Otolaryngol Head Neck Surg 2009 Aug;141(2):288-9. Epub 2009 Jun 4 doi: 10.1016/j.otohns.2009.02.031. PMID: 19643268

Diagnosis

Periocular inverted follicular keratosis: a retrospective series over 17 years.
Díez-Montero C, González González D, Pérez Martínez E, Schellini S, Galindo-Ferreiro A
Jpn J Ophthalmol 2019 Mar;63(2):210-214. Epub 2019 Jan 2 doi: 10.1007/s10384-018-00650-7. PMID: 30604112
Inverted follicular keratosis.
Soylu L, Akcali C, Aydogan LB, Ozsahinoglu C, Tuncer I
Am J Otolaryngol 1993 Jul-Aug;14(4):247-8. doi: 10.1016/0196-0709(93)90068-i. PMID: 8214316
Inverted follicular keratosis.
Sassani JW, Yanoff M
Am J Ophthalmol 1979 Jun;87(6):810-3. doi: 10.1016/0002-9394(79)90359-3. PMID: 453311
Inverted follicular keratosis.
Azzopardi JG, Laurini R
J Clin Pathol 1975 Jun;28(6):465-71. doi: 10.1136/jcp.28.6.465. PMID: 1141446Free PMC Article
INVERTED FOLLICULAR KERATOSIS.
MEHREGAN AH
Arch Dermatol 1964 Feb;89:229-35. doi: 10.1001/archderm.1964.01590260067012. PMID: 14081564

Therapy

Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding.
Pezzini C, Vassallo C, Grasso V, Rivetti N, Borroni G
Am J Dermatopathol 2015 Apr;37(4):323-5. doi: 10.1097/DAD.0000000000000083. PMID: 25238450
Inverted follicular keratosis of the nasal vestibule.
Villaret AB, Gily B, Aga A
Otolaryngol Head Neck Surg 2009 Aug;141(2):288-9. Epub 2009 Jun 4 doi: 10.1016/j.otohns.2009.02.031. PMID: 19643268

Prognosis

Periocular inverted follicular keratosis: a retrospective series over 17 years.
Díez-Montero C, González González D, Pérez Martínez E, Schellini S, Galindo-Ferreiro A
Jpn J Ophthalmol 2019 Mar;63(2):210-214. Epub 2019 Jan 2 doi: 10.1007/s10384-018-00650-7. PMID: 30604112
Pseudoepitheliomatous changes in a case of vegetating Darier–White disease: a unique histopathological finding.
Pezzini C, Vassallo C, Grasso V, Rivetti N, Borroni G
Am J Dermatopathol 2015 Apr;37(4):323-5. doi: 10.1097/DAD.0000000000000083. PMID: 25238450

Clinical prediction guides

Dermatoscopic profiling of inverted follicular keratosis in different skin phenotypes.
Demirdağ HG, Akay BN
Clin Exp Dermatol 2024 Aug 22;49(9):984-990. doi: 10.1093/ced/llae008. PMID: 38183679
Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases.
Goto K, Ogawa K, Hishima T, Oishi N, Tomita O, Tsuyuki T, Oda T, Iwahashi Y, Inaba Y, Honma K
Am J Dermatopathol 2022 Dec 1;44(12):891-899. Epub 2022 Jul 6 doi: 10.1097/DAD.0000000000002245. PMID: 36395445
Inverted follicular keratosis: dermoscopic and reflectance confocal microscopic features.
Armengot-Carbo M, Abrego A, Gonzalez T, Alarcon I, Alos L, Carrera C, Malvehy J, Puig S
Dermatology 2013;227(1):62-6. Epub 2013 Aug 24 doi: 10.1159/000351715. PMID: 23988627
Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma.
Roth LM, Look KY
Int J Gynecol Pathol 2000 Oct;19(4):369-73. doi: 10.1097/00004347-200010000-00012. PMID: 11109167
Inverted follicular keratosis and papillomavirus infection.
Hori K
Am J Dermatopathol 1991 Apr;13(2):145-51. doi: 10.1097/00000372-199104000-00007. PMID: 1851400

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