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Ganglioneuroma Component Present

MedGen UID:
274566
•Concept ID:
C1517446
•
Finding
Synonym: Ganglioneuromatous Element

Definition

A finding indicating the presence of large ganglion cells, neural cellular infiltrates and a stroma with Schwannian differentiation in a neoplastic tissue specimen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGanglioneuroma Component Present

Professional guidelines

PubMed

Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.
Zhang ZW, Guo X, Qi XP
Endocr Metab Immune Disord Drug Targets 2021;21(3):534-543. doi: 10.2174/1871530320666200910112230. PMID: 32914730
Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype.
Brat DJ, Gearing M, Goldthwaite PT, Wainer BH, Burger PC
Neuropathol Appl Neurobiol 2001 Jun;27(3):197-205. doi: 10.1046/j.1365-2990.2001.00311.x. PMID: 11489139
Dumbbell neurogenic tumors of the mediastinum. Diagnosis and management.
Akwari OE, Payne WS, Onofrio BM, Dines DE, Muhm JR
Mayo Clin Proc 1978 Jun;53(6):353-8. PMID: 651379

Recent clinical studies

Etiology

Robotic thoracic surgery for neurogenic tumors.
Niedermaier B, Griffo R, Grott M, Deissner H, Muley T, Neumann JO, Winter H, Eichhorn M
J Neurosurg 2024 Nov 1;141(5):1369-1377. Epub 2024 May 31 doi: 10.3171/2024.3.JNS232860. PMID: 38820608
Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.
Zhang ZW, Guo X, Qi XP
Endocr Metab Immune Disord Drug Targets 2021;21(3):534-543. doi: 10.2174/1871530320666200910112230. PMID: 32914730
Gangliocytomas in the sellar region.
Qiao N, Ye Z, Wang Y, Li S, Mao Y, Bao W, Che X, Qin Z, Xu W, Shen M, Chen H, Shou X, Zhao Y
Clin Neurol Neurosurg 2014 Nov;126:156-61. Epub 2014 Sep 7 doi: 10.1016/j.clineuro.2014.08.034. PMID: 25259876
Neuronal and mixed neuronal glial tumors associated to epilepsy. A heterogeneous and related group of tumours.
Moreno A, de Felipe J, García Sola R, Navarro A, Ramón y Cajal S
Histol Histopathol 2001 Apr;16(2):613-22. doi: 10.14670/HH-16.613. PMID: 11332717
'Gangliocytomas' of the pituitary: a heterogeneous group of lesions with differing histogenesis.
Geddes JF, Jansen GH, Robinson SF, Gömöri E, Holton JL, Monson JP, Besser GM, Révész T
Am J Surg Pathol 2000 Apr;24(4):607-13. doi: 10.1097/00000478-200004000-00017. PMID: 10757410

Diagnosis

An Unusual Case of Late Recurrence of MS Neuroblastoma in a Young Adult.
Boulter AC, Watt T
J Pediatr Hematol Oncol 2023 Jan 1;45(1):e124-e125. Epub 2022 Oct 26 doi: 10.1097/MPH.0000000000002584. PMID: 36598966
Neuroblastic tumors in young adults as a sequela of malignant neuroblastoma: report of two cases.
Adachi T, Yokoyama M, Fujii Y, Kinowaki Y, Kirimura S, Kubota K, Saida Y, Tateishi U
Abdom Radiol (NY) 2018 Jul;43(7):1531-1534. doi: 10.1007/s00261-018-1586-0. PMID: 29619527
Lhermitte-Duclos disease as a component of Cowden's syndrome. Case report and review of the literature.
Koch R, Scholz M, Nelen MR, Schwechheimer K, Epplen JT, Harders AG
J Neurosurg 1999 Apr;90(4):776-9. doi: 10.3171/jns.1999.90.4.0776. PMID: 10193626
Intrasellar gangliocytoma resembling pituitary adenoma.
Baysefer A, Gezen F, Kayali H, Erdoğan E, Timurkaynak E, Celasun B
Minim Invasive Neurosurg 1997 Sep;40(3):107-9. doi: 10.1055/s-2008-1053428. PMID: 9359090
Thoracic neuroblastoma/ganglioneuroma.
Young DG
J Pediatr Surg 1983 Feb;18(1):37-41. doi: 10.1016/s0022-3468(83)80270-x. PMID: 6834225

Therapy

Multidisciplinary surgical strategy for dumbbell neuroblastoma: A single-center experience of 32 cases.
Pio L, Blanc T, de Saint Denis T, Irtan S, Valteau-Couanet D, Michon J, Brisse H, Galmiche-Rolland L, Joyeux L, Odent T, Harte C, Glorion C, Zerah M, Sarnacki S
Pediatr Blood Cancer 2019 Aug;66 Suppl 3:e27670. Epub 2019 Mar 4 doi: 10.1002/pbc.27670. PMID: 30828979
Mixed Pituitary Gangliocytoma and Prolactinoma Resistant to the Cabergoline Treatment.
Yano S, Hide T, Uekawa K, Honda Y, Mikami Y, Kuratsu JI
World Neurosurg 2016 Nov;95:620.e17-620.e22. Epub 2016 Aug 13 doi: 10.1016/j.wneu.2016.08.011. PMID: 27535625
Membranous glomerulonephritis in a patient with an adrenal ganglioneuroma.
Wadhwa NK, Gupta M, Afolabi A, Miller F
Am J Kidney Dis 2004 Aug;44(2):363-8. doi: 10.1053/j.ajkd.2004.04.041. PMID: 15264196
MRI of ganglioneuroma: histologic correlation study.
Zhang Y, Nishimura H, Kato S, Fujimoto K, Ohkuma K, Kojima K, Uchida M, Hayabuchi N
J Comput Assist Tomogr 2001 Jul-Aug;25(4):617-23. doi: 10.1097/00004728-200107000-00018. PMID: 11473195

Prognosis

Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma.
Zhang Y, Ma Y, Liu Q, Du Y, Peng L, Zhou J, Zhao Z, Li C, Wang S
Front Immunol 2023;14:1197773. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1197773. PMID: 37790931Free PMC Article
Composite pheochromocytoma of the adrenal gland-a review of published cases.
Costa J, Jácome M, Souteiro P, Santos C, Cunha AL
Virchows Arch 2023 Aug;483(2):267-275. Epub 2023 Jan 16 doi: 10.1007/s00428-023-03492-y. PMID: 36645463
An Unusual Case of Late Recurrence of MS Neuroblastoma in a Young Adult.
Boulter AC, Watt T
J Pediatr Hematol Oncol 2023 Jan 1;45(1):e124-e125. Epub 2022 Oct 26 doi: 10.1097/MPH.0000000000002584. PMID: 36598966
Gangliocytomas in the sellar region.
Qiao N, Ye Z, Wang Y, Li S, Mao Y, Bao W, Che X, Qin Z, Xu W, Shen M, Chen H, Shou X, Zhao Y
Clin Neurol Neurosurg 2014 Nov;126:156-61. Epub 2014 Sep 7 doi: 10.1016/j.clineuro.2014.08.034. PMID: 25259876
Thoracic neuroblastoma/ganglioneuroma.
Young DG
J Pediatr Surg 1983 Feb;18(1):37-41. doi: 10.1016/s0022-3468(83)80270-x. PMID: 6834225

Clinical prediction guides

Robotic thoracic surgery for neurogenic tumors.
Niedermaier B, Griffo R, Grott M, Deissner H, Muley T, Neumann JO, Winter H, Eichhorn M
J Neurosurg 2024 Nov 1;141(5):1369-1377. Epub 2024 May 31 doi: 10.3171/2024.3.JNS232860. PMID: 38820608
Observation of Clinicopathologic Features of Pituitary Adenoma With Neuronal Differentiation.
Zheng L, Yan X, Hu C, Zhang P, Chen Y, Zheng Q, Hu L, Wang M, Li G, Wu P, Jiang C, Tian J, Zhang S, Wang X
Front Endocrinol (Lausanne) 2022;13:848762. Epub 2022 Mar 15 doi: 10.3389/fendo.2022.848762. PMID: 35370935Free PMC Article
Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.
Zhang ZW, Guo X, Qi XP
Endocr Metab Immune Disord Drug Targets 2021;21(3):534-543. doi: 10.2174/1871530320666200910112230. PMID: 32914730
Gangliocytomas in the sellar region.
Qiao N, Ye Z, Wang Y, Li S, Mao Y, Bao W, Che X, Qin Z, Xu W, Shen M, Chen H, Shou X, Zhao Y
Clin Neurol Neurosurg 2014 Nov;126:156-61. Epub 2014 Sep 7 doi: 10.1016/j.clineuro.2014.08.034. PMID: 25259876
Ganglioneuromatous paraganglioma of the cauda equina--a pathological case study.
Pytel P, Krausz T, Wollmann R, Utset MF
Hum Pathol 2005 Apr;36(4):444-6. doi: 10.1016/j.humpath.2005.01.024. PMID: 15892009

Recent systematic reviews

Composite phaeochromocytomas-a systematic review of published literature.
Dhanasekar K, Visakan V, Tahir F, Balasubramanian SP
Langenbecks Arch Surg 2022 Mar;407(2):517-527. Epub 2021 Mar 2 doi: 10.1007/s00423-021-02129-5. PMID: 33651160Free PMC Article
Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.
Zhang ZW, Guo X, Qi XP
Endocr Metab Immune Disord Drug Targets 2021;21(3):534-543. doi: 10.2174/1871530320666200910112230. PMID: 32914730

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