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Ovarian adenosarcoma

MedGen UID:
277458
•Concept ID:
C1335169
•
Neoplastic Process
Synonyms: adenosarcoma of ovary; Ovarian Adenosarcoma; ovarian adenosarcoma; Ovarian Mesodermal Adenosarcoma; ovarian mesodermal adenosarcoma; Ovarian Mullerian Adenosarcoma; ovarian Mullerian adenosarcoma; ovarian mullerian adenosarcoma; Ovarian Müllerian Adenosarcoma; ovarian Müllerian adenosarcoma; ovary adenosarcoma
 
Monarch Initiative: MONDO:0002880

Definition

A biphasic neoplasm that arises from the ovary and is characterized by the presence of mullerian-type epithelial tissue in a mesenchymal sarcomatous stroma. The presence of a high grade sarcomatous component is associated with recurrences and metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian adenosarcoma

Professional guidelines

PubMed

Annual report of the committee on gynecologic oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2021 and annual treatment report for 2016.
Kajiyama H, Tamauchi S, Takahashi F, Kawana K; Board members of the 2023 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology
J Obstet Gynaecol Res 2025 Jan;51(1):e16168. Epub 2024 Nov 25 doi: 10.1111/jog.16168. PMID: 39587792
Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors.
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792

Recent clinical studies

Etiology

Adenosarcoma of the ovary. A case report.
Litta P, Pozzan C, Sacco G, Merlin F, Saccardi C, Ambrosini A
Eur J Gynaecol Oncol 2004;25(4):507-8. PMID: 15285316
Benign and low grade variants of mixed mesodermal tumor (adenosarcoma) of the ovary and adnexal region.
Kao GF, Norris HJ
Cancer 1978 Sep;42(3):1314-24. doi: 10.1002/1097-0142(197809)42:3<1314::aid-cncr2820420342>3.0.co;2-v. PMID: 698918

Diagnosis

Endometriosis Malignant Transformation Review: Rhabdomyosarcoma Arising From an Endometrioma.
Nezhat C, Vu M, Vang N, Ganjoo K, Karam A, Folkins A, Nezhat A, Nezhat F
JSLS 2019 Oct-Dec;23(4) doi: 10.4293/JSLS.2019.00038. PMID: 31624455Free PMC Article
Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review.
Mandato VD, Torricelli F, Mastrofilippo V, Valli R, Aguzzoli L, La Sala GB
BMC Cancer 2018 Feb 5;18(1):134. doi: 10.1186/s12885-018-4037-y. PMID: 29402239Free PMC Article
Ovarian adenosarcoma arising from benign cystadenoma and associated intraoperative consultation pitfalls.
Chen ZW, Saad RS
Int J Gynecol Pathol 2010 Sep;29(5):415-8. doi: 10.1097/PGP.0b013e3181d90bca. PMID: 20736764
Ovarian adenosarcoma with extensive deciduoid morphology arising in endometriosis: a case report.
Manipadam MT, Munemane A, Emmanuel P, McCluggage WG
Int J Gynecol Pathol 2008 Jul;27(3):398-401. doi: 10.1097/PGP.0b013e318165e2d0. PMID: 18580317
Müllerian adenosarcoma of the ovary: case report and review of the literature.
Shetty M, Lal N, Vu NH
Ultrasound Q 2007 Sep;23(3):189-91. doi: 10.1097/RUQ.0b013e31814b94f7. PMID: 17805167

Prognosis

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review.
Mandato VD, Torricelli F, Mastrofilippo V, Valli R, Aguzzoli L, La Sala GB
BMC Cancer 2018 Feb 5;18(1):134. doi: 10.1186/s12885-018-4037-y. PMID: 29402239Free PMC Article
Adenosarcoma of the ovary. A case report.
Litta P, Pozzan C, Sacco G, Merlin F, Saccardi C, Ambrosini A
Eur J Gynaecol Oncol 2004;25(4):507-8. PMID: 15285316
Adenosarcoma of the ovary. A light- and electron-microscopic study with review of the literature.
Czernobilsky B, Gillespie JJ, Roth LM
Diagn Gynecol Obstet 1982 Spring;4(1):25-36. PMID: 6280945

Clinical prediction guides

CD10, estrogen and progesterone receptor expression in ovarian adenosarcoma.
Van Mieghem T, Abeler VM, Moerman P, Verbist L, Vergote I, Amant F
Gynecol Oncol 2005 Nov;99(2):493-6. Epub 2005 Jul 26 doi: 10.1016/j.ygyno.2005.06.013. PMID: 16051333

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