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Female reproductive system neoplasm

MedGen UID:
9004
•Concept ID:
C0017416
•
Neoplastic Process
Synonyms: Female Genital Neoplasm; Female Genital Neoplasms; Genital Neoplasm, Female; Genital Neoplasms, Female; Gynecologic Neoplasm; Gynecologic Neoplasms; Neoplasm, Female Genital; Neoplasm, Gynecologic; Neoplasms, Female Genital; Neoplasms, Gynecologic
SNOMED CT: Neoplasm of female genital organ (126907002); Tumor of female genital organs (126907002)
 
HPO: HP:0033020
Monarch Initiative: MONDO:0021148

Definition

A neoplasm that affects the female reproductive system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale reproductive system neoplasm

Professional guidelines

PubMed

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oaknin A, Bosse TJ, Creutzberg CL, Giornelli G, Harter P, Joly F, Lorusso D, Marth C, Makker V, Mirza MR, Ledermann JA, Colombo N; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2022 Sep;33(9):860-877. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.009. PMID: 35690222
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Marth C, Landoni F, Mahner S, McCormack M, Gonzalez-Martin A, Colombo N; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv72-iv83. doi: 10.1093/annonc/mdx220. PMID: 28881916

Recent clinical studies

Etiology

Hormone therapy (HT) in women with gynecologic cancers and in women at high risk for developing a gynecologic cancer: A Society of Gynecologic Oncology (SGO) clinical practice statement: This practice statement has been endorsed by The North American Menopause Society.
Sinno AK, Pinkerton J, Febbraro T, Jones N, Khanna N, Temkin S, Iglesias D, Pothuri B
Gynecol Oncol 2020 May;157(2):303-306. Epub 2020 Feb 15 doi: 10.1016/j.ygyno.2020.01.035. PMID: 32067815
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Cell-based immunotherapy in gynecologic malignancies.
Schaar B, Krishnan V, Tallapragada S, Chanana A, Dorigo O
Curr Opin Obstet Gynecol 2019 Feb;31(1):43-48. doi: 10.1097/GCO.0000000000000518. PMID: 30540582
Geriatric gynecology.
Perkins KE, King MC
Emerg Med Clin North Am 2012 Nov;30(4):1007-19. doi: 10.1016/j.emc.2012.08.011. PMID: 23137409

Diagnosis

Bleeding from Gynecologic Malignancies.
Hutchcraft ML, Miller RW
Obstet Gynecol Clin North Am 2022 Sep;49(3):607-622. doi: 10.1016/j.ogc.2022.02.022. PMID: 36122988
Update on MRI in Evaluation and Treatment of Endometrial Cancer.
Maheshwari E, Nougaret S, Stein EB, Rauch GM, Hwang KP, Stafford RJ, Klopp AH, Soliman PT, Maturen KE, Rockall AG, Lee SI, Sadowski EA, Venkatesan AM
Radiographics 2022 Nov-Dec;42(7):2112-2130. Epub 2022 Aug 26 doi: 10.1148/rg.220070. PMID: 36018785
Lower extremity lymphedema in patients with gynecologic malignancies.
Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136Free PMC Article
Revising the WHO classification: female genital tract tumours.
Cree IA, White VA, Indave BI, Lokuhetty D
Histopathology 2020 Jan;76(1):151-156. doi: 10.1111/his.13977. PMID: 31846528
Gynecologic Cancers: Molecular Updates 2018.
Abdulfatah E, Ahmed Q, Alosh B, Bandyopadhyay S, Bluth MH, Ali-Fehmi R
Clin Lab Med 2018 Jun;38(2):421-438. doi: 10.1016/j.cll.2018.02.007. PMID: 29776639

Therapy

Cell-based immunotherapy in gynecologic malignancies.
Kamat K, Krishnan V, Berek JS, Dorigo O
Curr Opin Obstet Gynecol 2021 Feb 1;33(1):13-18. doi: 10.1097/GCO.0000000000000676. PMID: 33278077
Immunotherapy in gynecological cancers: where are we?
Polastro L, Closset C, Kerger J
Curr Opin Oncol 2020 Sep;32(5):459-470. doi: 10.1097/CCO.0000000000000661. PMID: 32675594
Hormone therapy (HT) in women with gynecologic cancers and in women at high risk for developing a gynecologic cancer: A Society of Gynecologic Oncology (SGO) clinical practice statement: This practice statement has been endorsed by The North American Menopause Society.
Sinno AK, Pinkerton J, Febbraro T, Jones N, Khanna N, Temkin S, Iglesias D, Pothuri B
Gynecol Oncol 2020 May;157(2):303-306. Epub 2020 Feb 15 doi: 10.1016/j.ygyno.2020.01.035. PMID: 32067815
Cell-based immunotherapy in gynecologic malignancies.
Schaar B, Krishnan V, Tallapragada S, Chanana A, Dorigo O
Curr Opin Obstet Gynecol 2019 Feb;31(1):43-48. doi: 10.1097/GCO.0000000000000518. PMID: 30540582
Immunotherapy for gynaecological malignancies.
Coukos G, Conejo-Garcia JR, Roden RB, Wu TC
Expert Opin Biol Ther 2005 Sep;5(9):1193-210. doi: 10.1517/14712598.5.9.1193. PMID: 16120050

Prognosis

Obesity, weight loss and gynecologic neoplasms: a narrative review.
Halpern B, Mendes TB
Women Health 2022 May-Jun;62(5):372-383. Epub 2022 May 22 doi: 10.1080/03630242.2022.2066747. PMID: 35603570
Gynecologic Malignancies.
Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953
Chemotherapy, Biologic, and Immunotherapy Breakthroughs in Cancer Care.
Rojas C, Casablanca Y
Obstet Gynecol Clin North Am 2019 Mar;46(1):137-154. doi: 10.1016/j.ogc.2018.09.009. PMID: 30683260
Global Cancer in Women: Burden and Trends.
Torre LA, Islami F, Siegel RL, Ward EM, Jemal A
Cancer Epidemiol Biomarkers Prev 2017 Apr;26(4):444-457. Epub 2017 Feb 21 doi: 10.1158/1055-9965.EPI-16-0858. PMID: 28223433
Vulvar melanoma.
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827

Clinical prediction guides

Artificial intelligence-based risk stratification, accurate diagnosis and treatment prediction in gynecologic oncology.
Jiang Y, Wang C, Zhou S
Semin Cancer Biol 2023 Nov;96:82-99. Epub 2023 Sep 30 doi: 10.1016/j.semcancer.2023.09.005. PMID: 37783319
Therapeutic Options for Brain Metastases in Gynecologic Cancers.
Akapo A, Anishchenko K, Lefkowits C, Greenwood AL
Curr Treat Options Oncol 2022 Nov;23(11):1601-1613. Epub 2022 Oct 18 doi: 10.1007/s11864-022-01013-8. PMID: 36255665
Machine learning applications in gynecological cancer: A critical review.
Fiste O, Liontos M, Zagouri F, Stamatakos G, Dimopoulos MA
Crit Rev Oncol Hematol 2022 Nov;179:103808. Epub 2022 Sep 7 doi: 10.1016/j.critrevonc.2022.103808. PMID: 36087852
Nodal metastasis in gynecologic malignancies: Update on imaging and management.
Ramanathan S, Tirumani SH, Ojili V
Clin Imaging 2020 Feb;59(2):157-166. Epub 2019 Nov 28 doi: 10.1016/j.clinimag.2019.11.006. PMID: 31821973
Evaluating the Use of 18F-FDG PET CT for External Beam Radiotherapy Planning in Gynaecological Malignancies.
Kerr A, Reed N, Harrand R, Graham K, Sadozye AH
Curr Oncol Rep 2018 Sep 11;20(10):84. doi: 10.1007/s11912-018-0735-5. PMID: 30206712

Recent systematic reviews

Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis.
Bruni L, Albero G, Rowley J, Alemany L, Arbyn M, Giuliano AR, Markowitz LE, Broutet N, Taylor M
Lancet Glob Health 2023 Sep;11(9):e1345-e1362. doi: 10.1016/S2214-109X(23)00305-4. PMID: 37591583Free PMC Article
Systematic review and meta-analysis of prediction models used in cervical cancer.
Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article

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