U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fallopian Tube Undifferentiated Carcinoma

MedGen UID:
277839
•Concept ID:
C1336857
•
Neoplastic Process
Synonyms: Undifferentiated Carcinoma of Fallopian Tube; Undifferentiated Carcinoma of the Fallopian Tube; Undifferentiated Fallopian Tube Carcinoma

Definition

An invasive carcinoma arising from the fallopian tube. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation. [from NCI]

Professional guidelines

PubMed

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120
Staging classification for cancer of the ovary, fallopian tube, and peritoneum.
Prat J; FIGO Committee on Gynecologic Oncology
Int J Gynaecol Obstet 2014 Jan;124(1):1-5. Epub 2013 Oct 22 doi: 10.1016/j.ijgo.2013.10.001. PMID: 24219974

Recent clinical studies

Etiology

Hereditary Ovarian Carcinoma: Cancer Pathogenesis Looking beyond BRCA1 and BRCA2.
Samuel D, Diaz-Barbe A, Pinto A, Schlumbrecht M, George S
Cells 2022 Feb 4;11(3) doi: 10.3390/cells11030539. PMID: 35159349Free PMC Article
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Fallopian Tube Carcinoma.
Stasenko M, Fillipova O, Tew WP
J Oncol Pract 2019 Jul;15(7):375-382. Epub 2019 Jul 8 doi: 10.1200/JOP.18.00662. PMID: 31283415
Risk-reducing salpingectomy: Let us be opportunistic.
Long Roche KC, Abu-Rustum NR, Nourmoussavi M, Zivanovic O
Cancer 2017 May 15;123(10):1714-1720. Epub 2017 Mar 23 doi: 10.1002/cncr.30528. PMID: 28334425Free PMC Article
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Diagnosis

Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells.
Reavis HD, Gysler SM, McKenney GB, Knarr M, Lusk HJ, Rawat P, Rendulich HS, Mitchell MA, Berger DS, Moon JS, Ryu S, Mainigi M, Iwanicki MP, Hoon DS, Sanchez LM, Drapkin R
JCI Insight 2024 Mar 8;9(5) doi: 10.1172/jci.insight.170961. PMID: 38271085Free PMC Article
The Origin of Ovarian Cancer Species and Precancerous Landscape.
Shih IM, Wang Y, Wang TL
Am J Pathol 2021 Jan;191(1):26-39. Epub 2020 Oct 1 doi: 10.1016/j.ajpath.2020.09.006. PMID: 33011111Free PMC Article
Fallopian Tube Neoplasia and Mimics.
Kolin DL, Nucci MR
Surg Pathol Clin 2019 Jun;12(2):457-479. doi: 10.1016/j.path.2019.01.006. PMID: 31097111
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120
Coming into focus: the nonovarian origins of ovarian cancer.
Dubeau L, Drapkin R
Ann Oncol 2013 Nov;24 Suppl 8(Suppl 8):viii28-viii35. doi: 10.1093/annonc/mdt308. PMID: 24131966Free PMC Article

Therapy

Low grade serous ovarian cancer - A rare disease with increasing therapeutic options.
Zwimpfer TA, Tal O, Geissler F, Coelho R, Rimmer N, Jacob F, Heinzelmann-Schwarz V
Cancer Treat Rev 2023 Jan;112:102497. Epub 2022 Dec 10 doi: 10.1016/j.ctrv.2022.102497. PMID: 36525716
Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850).
Fagotti A, Ferrandina MG, Vizzielli G, Pasciuto T, Fanfani F, Gallotta V, Margariti PA, Chiantera V, Costantini B, Gueli Alletti S, Cosentino F, Scambia G
Int J Gynecol Cancer 2020 Nov;30(11):1657-1664. Epub 2020 Oct 7 doi: 10.1136/ijgc-2020-001640. PMID: 33028623
Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer.
Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Banerjee S, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, Lowe ES, Bloomfield R, DiSilvestro P
N Engl J Med 2018 Dec 27;379(26):2495-2505. Epub 2018 Oct 21 doi: 10.1056/NEJMoa1810858. PMID: 30345884
Pathogenesis and heterogeneity of ovarian cancer.
Kroeger PT Jr, Drapkin R
Curr Opin Obstet Gynecol 2017 Feb;29(1):26-34. doi: 10.1097/GCO.0000000000000340. PMID: 27898521Free PMC Article
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer.
Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A, Sovak MA, Yi J, Nycum LR
J Clin Oncol 2012 Jun 10;30(17):2039-45. Epub 2012 Apr 23 doi: 10.1200/JCO.2012.42.0505. PMID: 22529265Free PMC Article

Prognosis

Global epidemiology of epithelial ovarian cancer.
Webb PM, Jordan SJ
Nat Rev Clin Oncol 2024 May;21(5):389-400. Epub 2024 Mar 28 doi: 10.1038/s41571-024-00881-3. PMID: 38548868
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells.
Hu Z, Artibani M, Alsaadi A, Wietek N, Morotti M, Shi T, Zhong Z, Santana Gonzalez L, El-Sahhar S, Carrami EM, Mallett G, Feng Y, Masuda K, Zheng Y, Chong K, Damato S, Dhar S, Campo L, Garruto Campanile R, Soleymani Majd H, Rai V, Maldonado-Perez D, Jones S, Cerundolo V, Sauka-Spengler T, Yau C, Ahmed AA
Cancer Cell 2020 Feb 10;37(2):226-242.e7. doi: 10.1016/j.ccell.2020.01.003. PMID: 32049047
Fallopian Tube Carcinoma.
Stasenko M, Fillipova O, Tew WP
J Oncol Pract 2019 Jul;15(7):375-382. Epub 2019 Jul 8 doi: 10.1200/JOP.18.00662. PMID: 31283415
Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.
Weinberger V, Bednarikova M, Cibula D, Zikan M
Expert Rev Anticancer Ther 2016 Dec;16(12):1311-1321. Epub 2016 Oct 22 doi: 10.1080/14737140.2016.1247699. PMID: 27732120

Clinical prediction guides

Global epidemiology of epithelial ovarian cancer.
Webb PM, Jordan SJ
Nat Rev Clin Oncol 2024 May;21(5):389-400. Epub 2024 Mar 28 doi: 10.1038/s41571-024-00881-3. PMID: 38548868
Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer.
Vyhlídalová Kotrbová A, Gömöryová K, Mikulová A, Plešingerová H, Sladeček S, Kravec M, Hrachovinová Š, Potěšil D, Dunsmore G, Blériot C, Bied M, Kotouček J, Bednaříková M, Hausnerová J, Minář L, Crha I, Felsinger M, Zdráhal Z, Ginhoux F, Weinberger V, Bryja V, Pospíchalová V
J Extracell Vesicles 2024 Mar;13(3):e12420. doi: 10.1002/jev2.12420. PMID: 38490958Free PMC Article
Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850).
Fagotti A, Ferrandina MG, Vizzielli G, Pasciuto T, Fanfani F, Gallotta V, Margariti PA, Chiantera V, Costantini B, Gueli Alletti S, Cosentino F, Scambia G
Int J Gynecol Cancer 2020 Nov;30(11):1657-1664. Epub 2020 Oct 7 doi: 10.1136/ijgc-2020-001640. PMID: 33028623
Guideline No. 403: Initial Investigation and Management of Adnexal Masses.
Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853
Management of Preinvasive Lesions.
Patrono MG, Corzo C, Iniesta M, Ramirez PT
Clin Obstet Gynecol 2017 Dec;60(4):771-779. doi: 10.1097/GRF.0000000000000316. PMID: 28957950

Recent systematic reviews

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer.
Newhouse R, Nelissen E, El-Shakankery KH, Rogozińska E, Bain E, Veiga S, Morrison J
Cochrane Database Syst Rev 2023 Jul 5;7(7):CD006910. doi: 10.1002/14651858.CD006910.pub3. PMID: 37407274Free PMC Article
Outcome and Management of Serous Tubal Intraepithelial Carcinoma Following Opportunistic Salpingectomy: Systematic Review and Meta-Analysis.
Ruel-Laliberté J, Kasasni SM, Oprea D, Viau M
J Obstet Gynaecol Can 2022 Nov;44(11):1174-1180. Epub 2022 Sep 12 doi: 10.1016/j.jogc.2022.08.018. PMID: 36099965
Recommendations for diagnosing STIC: a systematic review and meta-analysis.
Bogaerts JMA, Steenbeek MP, van Bommel MHD, Bulten J, van der Laak JAWM, de Hullu JA, Simons M
Virchows Arch 2022 Apr;480(4):725-737. Epub 2021 Dec 1 doi: 10.1007/s00428-021-03244-w. PMID: 34850262Free PMC Article
Neoadjuvant and adjuvant systemic therapy for newly diagnosed stage II- IV epithelial ovary, fallopian tube, or primary peritoneal carcinoma: A systematic review.
Hirte H, Poon R, Yao X, May T, Ethier JL, Petz L, Speakman J, Elit L
Crit Rev Oncol Hematol 2021 Jun;162:103324. Epub 2021 Apr 20 doi: 10.1016/j.critrevonc.2021.103324. PMID: 33862245
ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.
Miller RE, Leary A, Scott CL, Serra V, Lord CJ, Bowtell D, Chang DK, Garsed DW, Jonkers J, Ledermann JA, Nik-Zainal S, Ray-Coquard I, Shah SP, Matias-Guiu X, Swisher EM, Yates LR
Ann Oncol 2020 Dec;31(12):1606-1622. Epub 2020 Sep 28 doi: 10.1016/j.annonc.2020.08.2102. PMID: 33004253

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...