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Chickenpox

MedGen UID:
2995
Concept ID:
C0008049
Disease or Syndrome
Synonyms: Chicken Pox; Varicella
SNOMED CT: Varicella infection (38907003); Chicken pox (38907003); Varicella (38907003); Chickenpox (38907003)
 
Monarch Initiative: MONDO:0005700

Definition

A contagious childhood disorder caused by the varicella zoster virus. It is transmitted via respiratory secretions and contact with chickenpox blister contents. It presents with a vesicular skin rash, usually associated with fever, headache, and myalgias. The pruritic fluid-filled vesicles occur 10-21 days after exposure and last for 3-4 days. An additional 3-4 days of malaise follows before the affected individual feels better. An individual is contagious 1-2 days prior to the appearance of the blisters until all blisters are crusted over. Generally, healthy individuals recover without complications. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChickenpox

Professional guidelines

PubMed

Patil A, Goldust M, Wollina U
Viruses 2022 Jan 19;14(2) doi: 10.3390/v14020192. PMID: 35215786Free PMC Article
Andrei G, Snoeck R
Molecules 2021 Feb 20;26(4) doi: 10.3390/molecules26041132. PMID: 33672709Free PMC Article
Saguil A, Kane S, Mercado M, Lauters R
Am Fam Physician 2017 Nov 15;96(10):656-663. PMID: 29431387

Recent clinical studies

Etiology

Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
Varela FH, Pinto LA, Scotta MC
Hum Vaccin Immunother 2019;15(3):645-657. Epub 2018 Dec 10 doi: 10.1080/21645515.2018.1546525. PMID: 30427766Free PMC Article
Lo Presti C, Curti C, Montana M, Bornet C, Vanelle P
Med Mal Infect 2019 Feb;49(1):1-8. Epub 2018 May 20 doi: 10.1016/j.medmal.2018.04.395. PMID: 29789159
McCarter-Spaulding DE
J Obstet Gynecol Neonatal Nurs 2001 Nov-Dec;30(6):667-73. doi: 10.1111/j.1552-6909.2001.tb00014.x. PMID: 11724203
Takahashi M, Asano Y, Kamiya H, Baba K
Microbiol Sci 1985 Aug;2(8):249-54. PMID: 2856380

Diagnosis

Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
Sauerbrei A
Eur J Clin Microbiol Infect Dis 2016 May;35(5):723-34. Epub 2016 Feb 12 doi: 10.1007/s10096-016-2605-0. PMID: 26873382
Cobelli Kett J
Pediatr Rev 2013 Jan;34(1):49-51. doi: 10.1542/pir.34-1-49. PMID: 23281363
English R
Pediatr Rev 2003 Nov;24(11):372-9. PMID: 14595034
Storr J
Prof Nurse 1997 Sep;12(12):869-71. PMID: 9326090

Therapy

Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
Warren-Gash C, Forbes H, Breuer J
Expert Rev Vaccines 2017 Dec;16(12):1191-1201. Epub 2017 Oct 30 doi: 10.1080/14760584.2017.1394843. PMID: 29047317Free PMC Article
Arvin AM
Curr Opin Investig Drugs 2002 Jul;3(7):996-9. PMID: 12186278
Abdel-Haq NM, Asmar BI
Indian J Pediatr 2001 Jul;68(7):649-54. doi: 10.1007/BF02752280. PMID: 11519289
Gershon AA
Infect Dis Clin North Am 2001 Mar;15(1):65-81, viii. doi: 10.1016/s0891-5520(05)70268-3. PMID: 11301823

Prognosis

Asada H
J Dermatol 2023 Mar;50(3):305-310. Epub 2022 Dec 20 doi: 10.1111/1346-8138.16666. PMID: 36539935
Gershon AA, Gershon MD, Shapiro ED
J Infect Dis 2021 Sep 30;224(12 Suppl 2):S387-S397. doi: 10.1093/infdis/jiaa573. PMID: 34590140Free PMC Article
Horváth A
Hum Vaccin Immunother 2021 Jun 3;17(6):1699-1702. Epub 2020 Dec 16 doi: 10.1080/21645515.2020.1843337. PMID: 33326320Free PMC Article
Varela FH, Pinto LA, Scotta MC
Hum Vaccin Immunother 2019;15(3):645-657. Epub 2018 Dec 10 doi: 10.1080/21645515.2018.1546525. PMID: 30427766Free PMC Article
White CJ
Clin Infect Dis 1997 May;24(5):753-61; quiz 762-3. doi: 10.1093/clinids/24.5.753. PMID: 9142766

Clinical prediction guides

Varela FH, Pinto LA, Scotta MC
Hum Vaccin Immunother 2019;15(3):645-657. Epub 2018 Dec 10 doi: 10.1080/21645515.2018.1546525. PMID: 30427766Free PMC Article
Warren-Gash C, Forbes H, Breuer J
Expert Rev Vaccines 2017 Dec;16(12):1191-1201. Epub 2017 Oct 30 doi: 10.1080/14760584.2017.1394843. PMID: 29047317Free PMC Article
Holmes CN
Can Fam Physician 2005 Jan;51(1):60-5. PMID: 15732223Free PMC Article
Andrews JI
Curr Opin Obstet Gynecol 2004 Apr;16(2):163-6. doi: 10.1097/00001703-200404000-00012. PMID: 15017347
Arvin AM
Infect Dis Clin North Am 1996 Sep;10(3):529-70. doi: 10.1016/s0891-5520(05)70312-3. PMID: 8856351

Recent systematic reviews

Mazzara C, Milani GP, Lava SAG, Bianchetti MG, Gualco G, Simonetti GD, Camozzi P, Kottanattu L
Acta Paediatr 2022 May;111(5):935-939. Epub 2022 Feb 27 doi: 10.1111/apa.16300. PMID: 35178772Free PMC Article
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2021 Nov 22;11(11):CD004407. doi: 10.1002/14651858.CD004407.pub5. PMID: 34806766Free PMC Article
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2020 Apr 20;4(4):CD004407. doi: 10.1002/14651858.CD004407.pub4. PMID: 32309885Free PMC Article
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ
J Obstet Gynaecol 2016 Jul;36(5):563-6. Epub 2016 Mar 10 doi: 10.3109/01443615.2015.1127905. PMID: 26965725
Cohen J, Breuer J
BMJ Clin Evid 2015 Jun 15;2015 PMID: 26077272Free PMC Article

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