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Borderline Ovarian Mucinous Tumor, Intestinal Type

MedGen UID:
307299
•Concept ID:
C1511265
•
Neoplastic Process

Definition

A neoplasm of low malignant potential arising from the ovary. It is characterized by the proliferation of neoplastic mucinous epithelial cells that resemble intestinal epithelial cells. There is no evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Mucinous Tumor, Intestinal Type

Professional guidelines

PubMed

Immunohistochemistry in the distinction between primary and metastatic ovarian mucinous neoplasms.
McCluggage WG
J Clin Pathol 2012 Jul;65(7):596-600. Epub 2011 Jul 18 doi: 10.1136/jcp.2010.085688. PMID: 21768188
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type.
Miller K, Millar J, McCluggage WG
Am J Surg Pathol 2011 Sep;35(9):1331-6. doi: 10.1097/PAS.0b013e3182233fce. PMID: 21836488
Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas.
Riopel MA, Ronnett BM, Kurman RJ
Am J Surg Pathol 1999 Jun;23(6):617-35. doi: 10.1097/00000478-199906000-00001. PMID: 10366144

Recent clinical studies

Etiology

Mixed Ovarian Neoplasms With Gastrointestinal-type Mucinous and Mullerian Epithelial Components: A Rare Group of Tumors Demonstrating the Phenotypic Plasticity of the Mullerian Epithelial Cell.
Chui MH, Ellenson LH
Am J Surg Pathol 2023 Jul 1;47(7):756-765. Epub 2023 May 1 doi: 10.1097/PAS.0000000000002045. PMID: 37125505Free PMC Article
Ovarian mucinous neoplasms, intestinal type, in premenopausal patients, develop in abnormal ovaries.
Silva E, Malpica A, Roma A, Ramalingam P, Kim G, Bakkar R, Loghavi S, Kim S, Shaye-Brown A, Marques-Piubelli ML, Chisholm G, Gershenson DM, Alvarado-Cabrero I
Hum Pathol 2021 Feb;108:32-41. Epub 2020 Nov 21 doi: 10.1016/j.humpath.2020.11.003. PMID: 33227313
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Seromucinous Tumors of the Ovary. What's in a Name?
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2016 Jan;35(1):78-81. doi: 10.1097/PGP.0000000000000266. PMID: 26598986Free PMC Article

Diagnosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Immunohistochemistry in the distinction between primary and metastatic ovarian mucinous neoplasms.
McCluggage WG
J Clin Pathol 2012 Jul;65(7):596-600. Epub 2011 Jul 18 doi: 10.1136/jcp.2010.085688. PMID: 21768188
Serous and mucinous borderline (low malignant potential) tumors of the ovary.
Acs G
Am J Clin Pathol 2005 Jun;123 Suppl:S13-57. doi: 10.1309/J6PXXK1HQJAEBVPM. PMID: 16100867

Therapy

Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Estrogen receptor expression is a common feature of ovarian borderline tumors.
Abu-Jawdeh GM, Jacobs TW, Niloff J, Cannistra SA
Gynecol Oncol 1996 Feb;60(2):301-7. doi: 10.1006/gyno.1996.0043. PMID: 8631556

Prognosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Serous and mucinous borderline (low malignant potential) tumors of the ovary.
Acs G
Am J Clin Pathol 2005 Jun;123 Suppl:S13-57. doi: 10.1309/J6PXXK1HQJAEBVPM. PMID: 16100867
Borderline epithelial tumors of the ovary.
Hart WR
Mod Pathol 2005 Feb;18 Suppl 2:S33-50. doi: 10.1038/modpathol.3800307. PMID: 15761465
Mucinous tumors of the ovary: a review.
Hart WR
Int J Gynecol Pathol 2005 Jan;24(1):4-25. PMID: 15626914

Clinical prediction guides

Comprehensive immunohistochemical analysis of the gastrointestinal and Müllerian phenotypes of 139 ovarian mucinous cystadenomas.
Halimi SA, Maeda D, Ushiku-Shinozaki A, Goto A, Oda K, Osuga Y, Fujii T, Ushiku T, Fukayama M
Hum Pathol 2021 Mar;109:21-30. Epub 2020 Dec 1 doi: 10.1016/j.humpath.2020.11.011. PMID: 33275953
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Immunohistochemical expression of ERα, ERβ, and TFF1 in type I and II ovarian tumors.
Abdou AG, Aiad HA, Asaad NY, Abd El-Wahed MM, Serag El-Dien M
Appl Immunohistochem Mol Morphol 2014 Jul;22(6):421-32. doi: 10.1097/PAI.0b013e31829bebf6. PMID: 24162262
CDX2 immunoreactivity in primary and metastatic ovarian mucinous tumours.
Fraggetta F, Pelosi G, Cafici A, Scollo P, Nuciforo P, Viale G
Virchows Arch 2003 Dec;443(6):782-6. Epub 2003 Oct 24 doi: 10.1007/s00428-003-0910-3. PMID: 14576939
Mucinous borderline and malignant tumors of the ovary. A clinicopathologic and DNA ploidy study of 92 cases.
Guerrieri C, Högberg T, Wingren S, Fristedt S, Simonsen E, Boeryd B
Cancer 1994 Oct 15;74(8):2329-40. doi: 10.1002/1097-0142(19941015)74:8<2329::aid-cncr2820740818>3.0.co;2-g. PMID: 7922984

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