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Myofibroblastic Differentiation

MedGen UID:
311021
•Concept ID:
C1709101
•
Finding

Definition

A morphologic finding that indicates the presence of myofibroblastic differentiation in a cellular infiltrate of a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyofibroblastic Differentiation

Professional guidelines

PubMed

Low to Intermediate (Borderline) Grade Breast Spindle Cell Lesions on Needle Biopsy: Diagnostic Approach and Clinical Management.
Russell DH, Montgomery EA, Susnik B
Adv Anat Pathol 2022 Sep 1;29(5):309-323. Epub 2022 Jul 12 doi: 10.1097/PAP.0000000000000353. PMID: 35838633
Heparin is a promising agent for the treatment of endometriosis-associated fibrosis.
Nasu K, Tsuno A, Hirao M, Kobayashi H, Yuge A, Narahara H
Fertil Steril 2010 Jun;94(1):46-51. Epub 2009 Apr 1 doi: 10.1016/j.fertnstert.2009.02.057. PMID: 19338998
Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiation.
Agaimy A, Gaumann A, Schroeder J, Dietmaier W, Hartmann A, Hofstaedter F, Wünsch PH, Mentzel T
Virchows Arch 2007 Nov;451(5):949-57. Epub 2007 Sep 14 doi: 10.1007/s00428-007-0495-3. PMID: 17874130

Recent clinical studies

Etiology

Identification of FGFR4 as a regulator of myofibroblast differentiation in pulmonary fibrosis.
Ghanem M, Justet A, Jaillet M, Vasarmidi E, Boghanim T, Hachem M, Vadel A, Joannes A, Mordant P, Balayev A, Adams T, Mal H, Cazes A, Poté N, Mailleux A, Crestani B
Am J Physiol Lung Cell Mol Physiol 2024 Dec 1;327(6):L818-L830. Epub 2024 Oct 1 doi: 10.1152/ajplung.00184.2023. PMID: 39350729
The role of fibrosis in endometriosis: a systematic review.
Vissers G, Giacomozzi M, Verdurmen W, Peek R, Nap A
Hum Reprod Update 2024 Dec 1;30(6):706-750. doi: 10.1093/humupd/dmae023. PMID: 39067455Free PMC Article
Clinicopathologic Correlations of Retrocorneal Membranes Associated With Endothelial Corneal Graft Failure.
Naranjo A, Pirakitikulr N, Pelaez D, Sabater AL, Monsalve P, Amescua G, Galor A, Dubovy SR
Am J Ophthalmol 2021 Feb;222:24-33. Epub 2020 Aug 15 doi: 10.1016/j.ajo.2020.08.016. PMID: 32810471Free PMC Article
Genetic variant of SRF-rearranged myofibroma with a misleading nuclear expression of STAT6 and STAT6 involvement as 3' fusion partner.
Nihous H, Macagno N, Baud-Massière J, Haffner A, Jouve JL, Gentet JC, Touzery C, Le Loarer F, Bouvier C
Virchows Arch 2021 Mar;478(3):597-603. Epub 2020 Jun 11 doi: 10.1007/s00428-020-02859-9. PMID: 32529351
Idiopathic epiretinal membranes. Ultrastructural characteristics and clinicopathologic correlation.
Smiddy WE, Maguire AM, Green WR, Michels RG, de la Cruz Z, Enger C, Jaeger M, Rice TA
Ophthalmology 1989 Jun;96(6):811-20; discussion 821. doi: 10.1016/s0161-6420(89)32811-9. PMID: 2740079

Diagnosis

Dedifferentiated Liposarcoma With Myofibroblastic Differentiation.
Wang GY, Lucas DR
Arch Pathol Lab Med 2018 Oct;142(10):1159-1163. doi: 10.5858/arpa.2018-0205-RA. PMID: 30281365
Dermatomyofibroma.
Campagnolo OA, Morais CF, Ughini MO, Aoki CM, Menegazzo M
An Bras Dermatol 2017 Jan-Feb;92(1):101-103. doi: 10.1590/abd1806-4841.20175189. PMID: 28225965Free PMC Article
Mammary-type myofibroblastoma of soft tissue.
Arsenovic N, Abdulla KE, Shamim KS
Indian J Pathol Microbiol 2011 Apr-Jun;54(2):391-3. doi: 10.4103/0377-4929.81646. PMID: 21623101
Fibroblastic rheumatism.
Marconi IM, Rivitti-Machado MC, Sotto MN, Nico MM
Clin Exp Dermatol 2009 Jan;34(1):29-32. doi: 10.1111/j.1365-2230.2008.02748.x. PMID: 19076791
Myofibrosarcoma.
Fisher C
Virchows Arch 2004 Sep;445(3):215-23. Epub 2004 Jun 2 doi: 10.1007/s00428-004-1038-9. PMID: 15173943

Therapy

Clinicopathologic Correlations of Retrocorneal Membranes Associated With Endothelial Corneal Graft Failure.
Naranjo A, Pirakitikulr N, Pelaez D, Sabater AL, Monsalve P, Amescua G, Galor A, Dubovy SR
Am J Ophthalmol 2021 Feb;222:24-33. Epub 2020 Aug 15 doi: 10.1016/j.ajo.2020.08.016. PMID: 32810471Free PMC Article
Development of calcific aortic valve disease: Do we know enough for new clinical trials?
Kostyunin AE, Yuzhalin AE, Ovcharenko EA, Kutikhin AG
J Mol Cell Cardiol 2019 Jul;132:189-209. Epub 2019 May 25 doi: 10.1016/j.yjmcc.2019.05.016. PMID: 31136747
Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma.
Lo CY, Michaeloudes C, Bhavsar PK, Huang CD, Wang CH, Kuo HP, Chung KF
J Allergy Clin Immunol 2015 May;135(5):1186-95.e1-6. Epub 2014 Dec 6 doi: 10.1016/j.jaci.2014.10.031. PMID: 25488691
Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation.
Silva D, Cáceres M, Arancibia R, Martínez C, Martínez J, Smith PC
J Periodontal Res 2012 Oct;47(5):599-607. doi: 10.1111/j.1600-0765.2012.01472.x. PMID: 23091836
Heparin is a promising agent for the treatment of endometriosis-associated fibrosis.
Nasu K, Tsuno A, Hirao M, Kobayashi H, Yuge A, Narahara H
Fertil Steril 2010 Jun;94(1):46-51. Epub 2009 Apr 1 doi: 10.1016/j.fertnstert.2009.02.057. PMID: 19338998

Prognosis

Dedifferentiated Liposarcoma With Myofibroblastic Differentiation.
Wang GY, Lucas DR
Arch Pathol Lab Med 2018 Oct;142(10):1159-1163. doi: 10.5858/arpa.2018-0205-RA. PMID: 30281365
Generalized infantile myofibromatosis with a monophasic primitive pattern.
Iwafuchi H, Tsuzuki T, Ito R, Miyake H, Okita H, Hamazaki M
Pathol Int 2015 Aug;65(8):432-7. Epub 2015 May 20 doi: 10.1111/pin.12312. PMID: 25989870
Epithelioid sarcoma of Enzinger.
Fisher C
Adv Anat Pathol 2006 May;13(3):114-21. doi: 10.1097/00125480-200605000-00002. PMID: 16778474
Myofibrosarcoma: a clinicopathologic study.
Montgomery E, Goldblum JR, Fisher C
Am J Surg Pathol 2001 Feb;25(2):219-28. doi: 10.1097/00000478-200102000-00010. PMID: 11176071
Idiopathic epiretinal membranes. Ultrastructural characteristics and clinicopathologic correlation.
Smiddy WE, Maguire AM, Green WR, Michels RG, de la Cruz Z, Enger C, Jaeger M, Rice TA
Ophthalmology 1989 Jun;96(6):811-20; discussion 821. doi: 10.1016/s0161-6420(89)32811-9. PMID: 2740079

Clinical prediction guides

Identification of FGFR4 as a regulator of myofibroblast differentiation in pulmonary fibrosis.
Ghanem M, Justet A, Jaillet M, Vasarmidi E, Boghanim T, Hachem M, Vadel A, Joannes A, Mordant P, Balayev A, Adams T, Mal H, Cazes A, Poté N, Mailleux A, Crestani B
Am J Physiol Lung Cell Mol Physiol 2024 Dec 1;327(6):L818-L830. Epub 2024 Oct 1 doi: 10.1152/ajplung.00184.2023. PMID: 39350729
The role of fibrosis in endometriosis: a systematic review.
Vissers G, Giacomozzi M, Verdurmen W, Peek R, Nap A
Hum Reprod Update 2024 Dec 1;30(6):706-750. doi: 10.1093/humupd/dmae023. PMID: 39067455Free PMC Article
Low-grade myofibroblastic sarcoma of the palate.
Yamada T, Yoshimura T, Kitamura N, Sasabe E, Ohno S, Yamamoto T
Int J Oral Sci 2012 Sep;4(3):170-3. Epub 2012 Aug 31 doi: 10.1038/ijos.2012.49. PMID: 22935748Free PMC Article
Fasciitis ossificans of the breast.
Sato K, Oda Y, Ueda Y, Katsuda S
Pathol Res Pract 2007;203(10):737-9. Epub 2007 Aug 28 doi: 10.1016/j.prp.2007.06.006. PMID: 17728072
Epithelioid sarcoma of Enzinger.
Fisher C
Adv Anat Pathol 2006 May;13(3):114-21. doi: 10.1097/00125480-200605000-00002. PMID: 16778474

Recent systematic reviews

The role of fibrosis in endometriosis: a systematic review.
Vissers G, Giacomozzi M, Verdurmen W, Peek R, Nap A
Hum Reprod Update 2024 Dec 1;30(6):706-750. doi: 10.1093/humupd/dmae023. PMID: 39067455Free PMC Article

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