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Lung Pleomorphic Adenoma

MedGen UID:
313372
Concept ID:
C1708780
Neoplastic Process

Definition

A very rare, well circumscribed, benign epithelial neoplasm that arises from the bronchus. It is characterized by the presence of epithelial cells, myoepithelial cells, and fibromyxoid stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Pleomorphic Adenoma

Professional guidelines

PubMed

Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866

Recent clinical studies

Etiology

Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Gontarz M, Urbańska-Gąsiorowska M, Bargiel J, Gąsiorowski K, Marecik T, Szczurowski P, Zapała J, Wyszyńska-Pawelec G
Med Oral Patol Oral Cir Bucal 2021 Sep 1;26(5):e626-e631. doi: 10.4317/medoral.24634. PMID: 34415003Free PMC Article
Imanishi N, Hirai A, Yoneda K, Shimajiri S, Kuwata T, Tashima Y, Takeuchi M, Iwai Y, Ichiki Y, Tanaka F
J Surg Oncol 2018 Jun;117(7):1563-1569. Epub 2018 Mar 30 doi: 10.1002/jso.25041. PMID: 29601633
Schwentner I, Obrist P, Thumfart W, Sprinzl G
Acta Otolaryngol 2006 Apr;126(4):340-5. doi: 10.1080/00016480500401035. PMID: 16608783
Bradley PJ
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):233-42. doi: 10.1159/000055748. PMID: 11408820

Diagnosis

Kuan K, Khader SN, El Hussein S
Diagn Cytopathol 2019 Sep;47(9):961-962. Epub 2019 Jun 4 doi: 10.1002/dc.24246. PMID: 31165583
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Gakidis I, Mihos PT, Chatziantoniou C, Stamatelopoulos A, Eftychiadis C, Mantas C
Asian Cardiovasc Thorac Ann 2014 Jun;22(5):620-2. Epub 2013 Oct 24 doi: 10.1177/0218492313479959. PMID: 24867040
Schwentner I, Obrist P, Thumfart W, Sprinzl G
Acta Otolaryngol 2006 Apr;126(4):340-5. doi: 10.1080/00016480500401035. PMID: 16608783
Yousem SA, Hochholzer L
Cancer 1987 Sep 15;60(6):1346-52. doi: 10.1002/1097-0142(19870915)60:6<1346::aid-cncr2820600631>3.0.co;2-0. PMID: 3040215

Therapy

Shinno Y, Goto Y, Sato J, Morita R, Matsumoto Y, Murakami S, Kanda S, Horinouchi H, Fujiwara Y, Yamamoto N, Ohe Y
Thorac Cancer 2019 Apr;10(4):738-743. Epub 2019 Feb 8 doi: 10.1111/1759-7714.12991. PMID: 30735003Free PMC Article
Ito K, Hataji O, Katsuta K, Kobayashi T, Gabazza EC, Yatabe Y, Taguchi O, Yamamoto N
J Thorac Oncol 2016 Oct;11(10):e117-9. Epub 2016 May 14 doi: 10.1016/j.jtho.2016.05.002. PMID: 27189927
Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P, Orbach D
Int J Pediatr Otorhinolaryngol 2010 Aug;74(8):942-5. doi: 10.1016/j.ijporl.2010.01.026. PMID: 20554035
Sharon E, Kelly RJ, Szabo E
Head Neck Oncol 2010 May 26;2:12. doi: 10.1186/1758-3284-2-12. PMID: 20504363Free PMC Article
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866

Prognosis

Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S
Mol Cell 2018 Jan 4;69(1):87-99.e7. Epub 2017 Dec 14 doi: 10.1016/j.molcel.2017.11.025. PMID: 29249655Free PMC Article
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Schwentner I, Obrist P, Thumfart W, Sprinzl G
Acta Otolaryngol 2006 Apr;126(4):340-5. doi: 10.1080/00016480500401035. PMID: 16608783
Yousem SA, Hochholzer L
Cancer 1987 Sep 15;60(6):1346-52. doi: 10.1002/1097-0142(19870915)60:6<1346::aid-cncr2820600631>3.0.co;2-0. PMID: 3040215

Clinical prediction guides

Monkman J, Moradi A, Yunis J, Ivison G, Mayer A, Ladwa R, O'Byrne K, Kulasinghe A
J Transl Med 2024 Mar 4;22(1):239. doi: 10.1186/s12967-024-05035-8. PMID: 38439077Free PMC Article
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93. doi: 10.1001/archotol.132.7.788. PMID: 16847191
Yousem SA, Hochholzer L
Cancer 1987 Sep 15;60(6):1346-52. doi: 10.1002/1097-0142(19870915)60:6<1346::aid-cncr2820600631>3.0.co;2-0. PMID: 3040215

Recent systematic reviews

Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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