U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lung Squamous Papilloma

MedGen UID:
317852
•Concept ID:
C1708785
•
Neoplastic Process
Synonyms: Bronchial Squamous Cell Papilloma; Lung Squamous Cell Papilloma

Definition

A papillary neoplasm that arises endobronchially. It is characterized by the presence of a delicate fibrovascular core lined by stratified squamous epithelium. Squamous cell papillomas can be solitary or multiple. Patients usually present with signs and symptoms of bronchial obstruction. Because of the possibility of recurrence and reported cases of squamous cell carcinomas arising at the excision site of squamous cell papillomas, complete excision is indicated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Papilloma

Professional guidelines

PubMed

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.
Gormley M, Dudding T, Kachuri L, Burrows K, Chong AHW, Martin RM, Thomas SJ, Tyrrell J, Ness AR, Brennan P, Munafò MR, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Tajara EH, Severino P, Toporcov TN, Lacko M, Waterboer T, Brenner N, Smith GD, Vincent EE, Richmond RC
BMC Med 2022 Jan 31;20(1):40. doi: 10.1186/s12916-022-02233-3. PMID: 35094705Free PMC Article
Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis: Long-Term Follow-Up.
Ruiz R, Balamuth N, Javia LR, Zur KB
Laryngoscope 2022 Oct;132(10):2071-2075. Epub 2022 Jan 19 doi: 10.1002/lary.30021. PMID: 35043981
Interferons in the treatment of human cancer.
Kirkwood JM, Ernstoff MS
J Clin Oncol 1984 Apr;2(4):336-52. doi: 10.1200/JCO.1984.2.4.336. PMID: 6323641

Recent clinical studies

Etiology

Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis: Long-Term Follow-Up.
Ruiz R, Balamuth N, Javia LR, Zur KB
Laryngoscope 2022 Oct;132(10):2071-2075. Epub 2022 Jan 19 doi: 10.1002/lary.30021. PMID: 35043981
Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients.
Chaussade H, Le Marec F, Coureau G, Leleux O, Neau D, Lazaro E, Amadeo B, Duffau P, Ferrand H, Courtault C, Foucan AS, Wittkop L, Bonnet F
AIDS 2022 Apr 1;36(5):665-673. doi: 10.1097/QAD.0000000000003152. PMID: 34923517
Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.
Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O
Crit Rev Oncol Hematol 2020 Apr;148:102895. Epub 2020 Jan 31 doi: 10.1016/j.critrevonc.2020.102895. PMID: 32062313
Cimetidine treatment for recurrent respiratory papillomatosis.
Harcourt JP, Worley G, Leighton SE
Int J Pediatr Otorhinolaryngol 1999 Dec 5;51(2):109-13. doi: 10.1016/s0165-5876(99)00279-7. PMID: 10619624
Role of cesarean section in prevention of recurrent respiratory papillomatosis--is there one?
Kosko JR, Derkay CS
Int J Pediatr Otorhinolaryngol 1996 Mar;35(1):31-8. doi: 10.1016/0165-5876(95)01279-6. PMID: 8882107

Diagnosis

What's new in benign lung tumours?
Boland JM
Histopathology 2024 Jan;84(1):124-135. Epub 2023 Sep 10 doi: 10.1111/his.15037. PMID: 37691383
Mixed squamous cell and glandular papilloma of the bronchus.
Cao Q, Li B, Lian H, Li J
Pulmonology 2024 Jan-Feb;30(1):96-97. Epub 2023 Aug 2 doi: 10.1016/j.pulmoe.2023.07.005. PMID: 37541933
The oral microbiota and its role in carcinogenesis.
Stasiewicz M, Karpiński TM
Semin Cancer Biol 2022 Nov;86(Pt 3):633-642. Epub 2021 Nov 4 doi: 10.1016/j.semcancer.2021.11.002. PMID: 34743032
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Cystic Lung Diseases: Algorithmic Approach.
Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, Galvin J, Rosen MJ, Lynch D, Travis W, Mehta S, Lazzaro R, Naidich D
Chest 2016 Oct;150(4):945-965. Epub 2016 May 13 doi: 10.1016/j.chest.2016.04.026. PMID: 27180915Free PMC Article

Therapy

Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.
Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O
Crit Rev Oncol Hematol 2020 Apr;148:102895. Epub 2020 Jan 31 doi: 10.1016/j.critrevonc.2020.102895. PMID: 32062313
A rapidly regressive esophageal squamous papilloma.
Khan AT, Dhorajiya P, Lung E
Gastrointest Endosc 2019 Oct;90(4):684-685. Epub 2019 May 15 doi: 10.1016/j.gie.2019.05.015. PMID: 31102642
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782
Systemic cidofovir in papillomatosis.
Van Valckenborgh I, Wellens W, De Boeck K, Snoeck R, De Clercq E, Feenstra L
Clin Infect Dis 2001 Feb 1;32(3):E62-4. Epub 2001 Jan 23 doi: 10.1086/318497. PMID: 11170974
Recurrent respiratory papillomatosis.
Derkay CS, Rimell FL, Thompson JW
Head Neck 1998 Aug;20(5):418-24. doi: 10.1002/(sici)1097-0347(199808)20:5<418::aid-hed10>3.0.co;2-c. PMID: 9663670

Prognosis

Unmasking the tissue-resident eukaryotic DNA virome in humans.
Pyöriä L, Pratas D, Toppinen M, Hedman K, Sajantila A, Perdomo MF
Nucleic Acids Res 2023 Apr 24;51(7):3223-3239. doi: 10.1093/nar/gkad199. PMID: 36951096Free PMC Article
Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis: Long-Term Follow-Up.
Ruiz R, Balamuth N, Javia LR, Zur KB
Laryngoscope 2022 Oct;132(10):2071-2075. Epub 2022 Jan 19 doi: 10.1002/lary.30021. PMID: 35043981
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Cimetidine treatment for recurrent respiratory papillomatosis.
Harcourt JP, Worley G, Leighton SE
Int J Pediatr Otorhinolaryngol 1999 Dec 5;51(2):109-13. doi: 10.1016/s0165-5876(99)00279-7. PMID: 10619624
Role of cesarean section in prevention of recurrent respiratory papillomatosis--is there one?
Kosko JR, Derkay CS
Int J Pediatr Otorhinolaryngol 1996 Mar;35(1):31-8. doi: 10.1016/0165-5876(95)01279-6. PMID: 8882107

Clinical prediction guides

Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le QT, Goldfarb D, Major MB
Mol Cell Proteomics 2023 Nov;22(11):100647. Epub 2023 Sep 15 doi: 10.1016/j.mcpro.2023.100647. PMID: 37716475Free PMC Article
Unmasking the tissue-resident eukaryotic DNA virome in humans.
Pyöriä L, Pratas D, Toppinen M, Hedman K, Sajantila A, Perdomo MF
Nucleic Acids Res 2023 Apr 24;51(7):3223-3239. doi: 10.1093/nar/gkad199. PMID: 36951096Free PMC Article
Ciliated muconodular papillary tumor of the lung: a newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: a case report and review of literature.
Chuang HW, Liao JB, Chang HC, Wang JS, Lin SL, Hsieh PP
Pathol Int 2014 Jul;64(7):352-7. doi: 10.1111/pin.12179. PMID: 25047506
Systemic cidofovir in papillomatosis.
Van Valckenborgh I, Wellens W, De Boeck K, Snoeck R, De Clercq E, Feenstra L
Clin Infect Dis 2001 Feb 1;32(3):E62-4. Epub 2001 Jan 23 doi: 10.1086/318497. PMID: 11170974
The trachea: pathologic conditions and trauma.
Dennie CJ, Coblentz CL
Can Assoc Radiol J 1993 Jun;44(3):157-67. PMID: 8504326

Recent systematic reviews

What investigations are needed to optimally monitor for malignancies in SLE?
Tessier-Cloutier B, Clarke AE, Pineau CA, Keeling S, Bissonauth A, Ramsey-Goldman R, Lee J, Bernatsky S
Lupus 2015 Jul;24(8):781-7. Epub 2015 Mar 4 doi: 10.1177/0961203315575587. PMID: 25742688
Human papilloma virus in non-small cell lung cancer in never smokers: a systematic review of the literature.
Hasegawa Y, Ando M, Kubo A, Isa S, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M, Kawaguchi T
Lung Cancer 2014 Jan;83(1):8-13. Epub 2013 Oct 31 doi: 10.1016/j.lungcan.2013.10.002. PMID: 24252423
Survival outcomes of squamous cell carcinoma arising from sinonasal inverted papilloma: report of 6 cases with systematic review and pooled analysis.
Tanvetyanon T, Qin D, Padhya T, Kapoor R, McCaffrey J, Trotti A
Am J Otolaryngol 2009 Jan-Feb;30(1):38-43. Epub 2008 Jul 22 doi: 10.1016/j.amjoto.2008.02.005. PMID: 19027511
Lung involvement in juvenile onset recurrent respiratory papillomatosis: a systematic review of the literature.
Gélinas JF, Manoukian J, Côté A
Int J Pediatr Otorhinolaryngol 2008 Apr;72(4):433-52. Epub 2008 Feb 20 doi: 10.1016/j.ijporl.2007.12.003. PMID: 18281102
Transbronchial needle injection: a systematic review of a new diagnostic and therapeutic paradigm.
Seymour CW, Krimsky WS, Sager J, Kruklitis RJ, Lund ME, Musani AI, Sterman DH
Respiration 2006;73(1):78-89. doi: 10.1159/000090994. PMID: 16498271

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...