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Lung Squamous Papilloma

MedGen UID:
317852
•Concept ID:
C1708785
•
Neoplastic Process
Synonyms: Bronchial Squamous Cell Papilloma; Lung Squamous Cell Papilloma

Definition

A papillary neoplasm that arises endobronchially. It is characterized by the presence of a delicate fibrovascular core lined by stratified squamous epithelium. Squamous cell papillomas can be solitary or multiple. Patients usually present with signs and symptoms of bronchial obstruction. Because of the possibility of recurrence and reported cases of squamous cell carcinomas arising at the excision site of squamous cell papillomas, complete excision is indicated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Papilloma

Professional guidelines

PubMed

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.
Gormley M, Dudding T, Kachuri L, Burrows K, Chong AHW, Martin RM, Thomas SJ, Tyrrell J, Ness AR, Brennan P, Munafò MR, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Tajara EH, Severino P, Toporcov TN, Lacko M, Waterboer T, Brenner N, Smith GD, Vincent EE, Richmond RC
BMC Med 2022 Jan 31;20(1):40. doi: 10.1186/s12916-022-02233-3. PMID: 35094705Free PMC Article
Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis: Long-Term Follow-Up.
Ruiz R, Balamuth N, Javia LR, Zur KB
Laryngoscope 2022 Oct;132(10):2071-2075. Epub 2022 Jan 19 doi: 10.1002/lary.30021. PMID: 35043981
Guidelines for screening, prophylaxis and critical information prior to initiating anti-TNF-alpha treatment.
Nordgaard-Lassen I, Dahlerup JF, Belard E, Gerstoft J, Kjeldsen J, Kragballe K, Ravn P, Sørensen IJ, Theede K, Tjellesen L; Danish Society for Gastroenterology
Dan Med J 2012 Jul;59(7):C4480. PMID: 22759856

Recent clinical studies

Etiology

Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients.
Chaussade H, Le Marec F, Coureau G, Leleux O, Neau D, Lazaro E, Amadeo B, Duffau P, Ferrand H, Courtault C, Foucan AS, Wittkop L, Bonnet F
AIDS 2022 Apr 1;36(5):665-673. doi: 10.1097/QAD.0000000000003152. PMID: 34923517
Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.
Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O
Crit Rev Oncol Hematol 2020 Apr;148:102895. Epub 2020 Jan 31 doi: 10.1016/j.critrevonc.2020.102895. PMID: 32062313
Cancer control in Bangladesh.
Hussain SA, Sullivan R
Jpn J Clin Oncol 2013 Dec;43(12):1159-69. Epub 2013 Oct 25 doi: 10.1093/jjco/hyt140. PMID: 24163419Free PMC Article
Morphology, DNA ploidy and HPV in lung cancer and head and neck cancer.
Kotb WF, Petersen I
Pathol Res Pract 2012 Jan 15;208(1):1-8. Epub 2011 Dec 7 doi: 10.1016/j.prp.2011.10.009. PMID: 22154608
Aetiology of cancer in Asia.
Park S, Bae J, Nam BH, Yoo KY
Asian Pac J Cancer Prev 2008 Jul-Sep;9(3):371-80. PMID: 18990005

Diagnosis

Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le QT, Goldfarb D, Major MB
Mol Cell Proteomics 2023 Nov;22(11):100647. Epub 2023 Sep 15 doi: 10.1016/j.mcpro.2023.100647. PMID: 37716475Free PMC Article
The oral microbiota and its role in carcinogenesis.
Stasiewicz M, Karpiński TM
Semin Cancer Biol 2022 Nov;86(Pt 3):633-642. Epub 2021 Nov 4 doi: 10.1016/j.semcancer.2021.11.002. PMID: 34743032
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Cystic Lung Diseases: Algorithmic Approach.
Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, Galvin J, Rosen MJ, Lynch D, Travis W, Mehta S, Lazzaro R, Naidich D
Chest 2016 Oct;150(4):945-965. Epub 2016 May 13 doi: 10.1016/j.chest.2016.04.026. PMID: 27180915Free PMC Article
Mixed squamous cell and glandular papilloma of the lung: a case study and literature review.
Inamura K, Kumasaka T, Furuta R, Shimada K, Hiyama N, Furuhata Y, Tanaka I, Takemura T
Pathol Int 2011 Apr;61(4):252-8. Epub 2011 Mar 8 doi: 10.1111/j.1440-1827.2011.02659.x. PMID: 21418399

Therapy

Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le QT, Goldfarb D, Major MB
Mol Cell Proteomics 2023 Nov;22(11):100647. Epub 2023 Sep 15 doi: 10.1016/j.mcpro.2023.100647. PMID: 37716475Free PMC Article
Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.
Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O
Crit Rev Oncol Hematol 2020 Apr;148:102895. Epub 2020 Jan 31 doi: 10.1016/j.critrevonc.2020.102895. PMID: 32062313
Cancer control in Bangladesh.
Hussain SA, Sullivan R
Jpn J Clin Oncol 2013 Dec;43(12):1159-69. Epub 2013 Oct 25 doi: 10.1093/jjco/hyt140. PMID: 24163419Free PMC Article
Mixed squamous cell and glandular papilloma of the lung: a case study and literature review.
Inamura K, Kumasaka T, Furuta R, Shimada K, Hiyama N, Furuhata Y, Tanaka I, Takemura T
Pathol Int 2011 Apr;61(4):252-8. Epub 2011 Mar 8 doi: 10.1111/j.1440-1827.2011.02659.x. PMID: 21418399
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782

Prognosis

Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le QT, Goldfarb D, Major MB
Mol Cell Proteomics 2023 Nov;22(11):100647. Epub 2023 Sep 15 doi: 10.1016/j.mcpro.2023.100647. PMID: 37716475Free PMC Article
Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients.
Chaussade H, Le Marec F, Coureau G, Leleux O, Neau D, Lazaro E, Amadeo B, Duffau P, Ferrand H, Courtault C, Foucan AS, Wittkop L, Bonnet F
AIDS 2022 Apr 1;36(5):665-673. doi: 10.1097/QAD.0000000000003152. PMID: 34923517
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Cancer control in Bangladesh.
Hussain SA, Sullivan R
Jpn J Clin Oncol 2013 Dec;43(12):1159-69. Epub 2013 Oct 25 doi: 10.1093/jjco/hyt140. PMID: 24163419Free PMC Article
Morphology, DNA ploidy and HPV in lung cancer and head and neck cancer.
Kotb WF, Petersen I
Pathol Res Pract 2012 Jan 15;208(1):1-8. Epub 2011 Dec 7 doi: 10.1016/j.prp.2011.10.009. PMID: 22154608

Clinical prediction guides

Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le QT, Goldfarb D, Major MB
Mol Cell Proteomics 2023 Nov;22(11):100647. Epub 2023 Sep 15 doi: 10.1016/j.mcpro.2023.100647. PMID: 37716475Free PMC Article
A solitary mixed squamous cell and glandular papilloma of the lung.
Kozu Y, Maniwa T, Ohde Y, Nakajima T
Ann Thorac Cardiovasc Surg 2014;20 Suppl:625-8. Epub 2013 Aug 30 doi: 10.5761/atcs.cr.13-00029. PMID: 23995347
Cancer control in Bangladesh.
Hussain SA, Sullivan R
Jpn J Clin Oncol 2013 Dec;43(12):1159-69. Epub 2013 Oct 25 doi: 10.1093/jjco/hyt140. PMID: 24163419Free PMC Article
Role of beta-defensins in oral epithelial health and disease.
Abiko Y, Saitoh M, Nishimura M, Yamazaki M, Sawamura D, Kaku T
Med Mol Morphol 2007 Dec;40(4):179-84. Epub 2007 Dec 21 doi: 10.1007/s00795-007-0381-8. PMID: 18085375
Lung cancer epidemiology and risk factors in Asia and Africa.
Lam WK, White NW, Chan-Yeung MM
Int J Tuberc Lung Dis 2004 Sep;8(9):1045-57. PMID: 15455588

Recent systematic reviews

What investigations are needed to optimally monitor for malignancies in SLE?
Tessier-Cloutier B, Clarke AE, Pineau CA, Keeling S, Bissonauth A, Ramsey-Goldman R, Lee J, Bernatsky S
Lupus 2015 Jul;24(8):781-7. Epub 2015 Mar 4 doi: 10.1177/0961203315575587. PMID: 25742688
Human papilloma virus in non-small cell lung cancer in never smokers: a systematic review of the literature.
Hasegawa Y, Ando M, Kubo A, Isa S, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M, Kawaguchi T
Lung Cancer 2014 Jan;83(1):8-13. Epub 2013 Oct 31 doi: 10.1016/j.lungcan.2013.10.002. PMID: 24252423
Survival outcomes of squamous cell carcinoma arising from sinonasal inverted papilloma: report of 6 cases with systematic review and pooled analysis.
Tanvetyanon T, Qin D, Padhya T, Kapoor R, McCaffrey J, Trotti A
Am J Otolaryngol 2009 Jan-Feb;30(1):38-43. Epub 2008 Jul 22 doi: 10.1016/j.amjoto.2008.02.005. PMID: 19027511
Lung involvement in juvenile onset recurrent respiratory papillomatosis: a systematic review of the literature.
Gélinas JF, Manoukian J, Côté A
Int J Pediatr Otorhinolaryngol 2008 Apr;72(4):433-52. Epub 2008 Feb 20 doi: 10.1016/j.ijporl.2007.12.003. PMID: 18281102
Transbronchial needle injection: a systematic review of a new diagnostic and therapeutic paradigm.
Seymour CW, Krimsky WS, Sager J, Kruklitis RJ, Lund ME, Musani AI, Sterman DH
Respiration 2006;73(1):78-89. doi: 10.1159/000090994. PMID: 16498271

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