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Benign Squamous Cell Neoplasm

MedGen UID:
141634
•Concept ID:
C0474800
•
Neoplastic Process
Synonyms: Benign Epidermoid Cell Neoplasm; Benign Epidermoid Cell Tumor; Benign squamous cell tumor; Benign Squamous Cell Tumor
SNOMED CT: Benign squamous cell tumor (252994001)

Definition

A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Sinonasal Papillomas-An Up-To-Date Review for Practicing Pathologists.
Perry WR, Udager AM
Surg Pathol Clin 2024 Dec;17(4):561-576. doi: 10.1016/j.path.2024.07.012. PMID: 39489549
Cutaneous Squamous Cell Carcinoma: From Biology to Therapy.
Corchado-Cobos R, García-Sancha N, González-Sarmiento R, Pérez-Losada J, Cañueto J
Int J Mol Sci 2020 Apr 22;21(8) doi: 10.3390/ijms21082956. PMID: 32331425Free PMC Article
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Oral cancer or periimplantitis: A clinical dilemma.
Bhandari S, Rattan V, Panda N, Vaiphei K, Mittal BR
J Prosthet Dent 2016 Jun;115(6):658-61. Epub 2016 Jan 21 doi: 10.1016/j.prosdent.2015.10.022. PMID: 26803178
Loss of heterozygosity: a potential tool in management of oral premalignant lesions?
Zhang L, Rosin MP
J Oral Pathol Med 2001 Oct;30(9):513-20. doi: 10.1034/j.1600-0714.2001.300901.x. PMID: 11555152

Diagnosis

Common benign and malignant oral mucosal disease.
Wong T, Yap T, Wiesenfeld D
Aust J Gen Pract 2020 Sep;49(9):568-573. doi: 10.31128/AJGP-02-20-5250-01. PMID: 32864671
Usefulness of dermoscopy to improve the clinical and histopathologic diagnosis of skin cancers.
Yélamos O, Braun RP, Liopyris K, Wolner ZJ, Kerl K, Gerami P, Marghoob AA
J Am Acad Dermatol 2019 Feb;80(2):365-377. Epub 2018 Oct 13 doi: 10.1016/j.jaad.2018.07.072. PMID: 30321580
Cutaneous Squamous Cell Carcinoma.
Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498
Congenital epulis.
Merglová V, Mukensnabl P, Andrle P
BMJ Case Rep 2012 Jul 9;2012 doi: 10.1136/bcr.01.2012.5483. PMID: 22778448Free PMC Article
Inverted follicular keratosis.
Azzopardi JG, Laurini R
J Clin Pathol 1975 Jun;28(6):465-71. doi: 10.1136/jcp.28.6.465. PMID: 1141446Free PMC Article

Therapy

When to suspect a non-melanoma skin cancer.
Smith H, Wernham A, Patel A
BMJ 2020 Mar 11;368:m692. doi: 10.1136/bmj.m692. PMID: 32161002
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032
Recurrent respiratory papillomatosis.
Tasca RA, Clarke RW
Arch Dis Child 2006 Aug;91(8):689-91. doi: 10.1136/adc.2005.090514. PMID: 16861486Free PMC Article
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748
Emergency oesophagectomy.
Kerr WF
Thorax 1968 Mar;23(2):204-9. doi: 10.1136/thx.23.2.204. PMID: 5654080Free PMC Article

Prognosis

Usefulness of dermoscopy to improve the clinical and histopathologic diagnosis of skin cancers.
Yélamos O, Braun RP, Liopyris K, Wolner ZJ, Kerl K, Gerami P, Marghoob AA
J Am Acad Dermatol 2019 Feb;80(2):365-377. Epub 2018 Oct 13 doi: 10.1016/j.jaad.2018.07.072. PMID: 30321580
Bazex syndrome.
Rodrigues IA Jr, Gresta LT, Cruz RC, Carvalho GG, Moreira MH
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20132488. PMID: 24346922Free PMC Article
Transhiatal esophagectomy.
Lin J, Iannettoni MD
Surg Clin North Am 2005 Jun;85(3):593-610. doi: 10.1016/j.suc.2005.01.009. PMID: 15927654
Skin cancer of the head and neck.
Hochman M, Lang P
Med Clin North Am 1999 Jan;83(1):261-82, xii. doi: 10.1016/s0025-7125(05)70101-2. PMID: 9927974
Sphenoid sinus malignancies.
Donald PJ, Boggan JE
J Craniofac Surg 1995 Jan;6(1):15-23. doi: 10.1097/00001665-199501000-00007. PMID: 8601000

Clinical prediction guides

Imaging findings of papillary breast lesions: a pictorial review.
Kestelman FP, Gomes CF, Fontes FB, Marchiori E
Clin Radiol 2014 Apr;69(4):436-41. Epub 2014 Jan 20 doi: 10.1016/j.crad.2013.11.020. PMID: 24457016
Referrals by general practitioners for suspicious skin lesions: the urgency of training.
van Rijsingen MC, Hanssen SC, Groenewoud JM, van der Wilt GJ, Gerritsen MJ
Acta Derm Venereol 2014 Mar;94(2):138-41. doi: 10.2340/00015555-1752. PMID: 24352366
Loss of heterozygosity: a potential tool in management of oral premalignant lesions?
Zhang L, Rosin MP
J Oral Pathol Med 2001 Oct;30(9):513-20. doi: 10.1034/j.1600-0714.2001.300901.x. PMID: 11555152
New air-fluid levels in bullous lung disease: a reevaluation.
Richardson MS, Reddy VD, Read CA
J Natl Med Assoc 1996 Mar;88(3):185-7. PMID: 8839034Free PMC Article
Respiratory cytology: a review of non-neoplastic mimics of malignancy.
Naryshkin S, Young NA
Diagn Cytopathol 1993;9(1):89-97. doi: 10.1002/dc.2840090120. PMID: 8384547

Recent systematic reviews

Serum microRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma: a meta-analysis.
Chen Y, Dong B, Huang L, Huang H
Bosn J Basic Med Sci 2022 Oct 23;22(6):862-871. doi: 10.17305/bjbms.2022.7343. PMID: 35678022Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Systematic review with meta-analysis: artificial intelligence in the diagnosis of oesophageal diseases.
Visaggi P, Barberio B, Gregori D, Azzolina D, Martinato M, Hassan C, Sharma P, Savarino E, de Bortoli N
Aliment Pharmacol Ther 2022 Mar;55(5):528-540. Epub 2022 Jan 30 doi: 10.1111/apt.16778. PMID: 35098562Free PMC Article
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Zhang Y, Wang Y, Wan Z, Liu S, Cao Y, Zeng Z
PLoS One 2014;9(2):e90362. Epub 2014 Feb 27 doi: 10.1371/journal.pone.0090362. PMID: 24587339Free PMC Article

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