U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lymphatic Invasion

MedGen UID:
317854
•Concept ID:
C1708790
•
Finding
Synonyms: Lymphovascular Invasion; Lymphovascular Space Invasion

Definition

A term referring to the presence of tumor emboli or tumor masses within lymphatic vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphatic Invasion

Professional guidelines

PubMed

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management.
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Risk assessment in early colorectal cancer: histological and molecular markers.
Resch A, Langner C
Dig Dis 2015;33(1):77-85. Epub 2014 Dec 17 doi: 10.1159/000366036. PMID: 25531500

Recent clinical studies

Etiology

The Expression Patterns and Implications of MALAT1, MANCR, PSMA3-AS1 and miR-101 in Esophageal Adenocarcinoma.
Syllaios A, Gazouli M, Vailas M, Mylonas KS, Sakellariou S, Sougioultzis S, Karavokyros I, Liakakos T, Schizas D
Int J Mol Sci 2023 Dec 20;25(1) doi: 10.3390/ijms25010098. PMID: 38203269Free PMC Article
Neutrophils promote tumor invasion via FAM3C-mediated epithelial-to-mesenchymal transition in gastric cancer.
Wang Y, Li X, Zhang T, Li F, Shen Y, He Y, You Q, Zhang Y, Zhai J, Yao X, Shen L
Int J Biol Sci 2023;19(5):1352-1368. Epub 2023 Feb 21 doi: 10.7150/ijbs.79022. PMID: 37056931Free PMC Article
Primary pulmonary myoepithelial carcinoma.
Hysi I, Wattez H, Benhamed L, Porte H
Interact Cardiovasc Thorac Surg 2011 Aug;13(2):226-8. Epub 2011 May 30 doi: 10.1510/icvts.2011.270934. PMID: 21628324
The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer.
Stewart TH, Tsai SC
Clin Exp Metastasis 1993 Jul;11(4):295-305. doi: 10.1007/BF00058049. PMID: 8319378
Carcinoid tumors of the appendix.
Bowman GA, Rosenthal D
Am J Surg 1983 Dec;146(6):700-3. doi: 10.1016/0002-9610(83)90321-5. PMID: 6650751

Diagnosis

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management.
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
BCC metastasis: a very rare sequela of a common disease- a case report documenting lymphatic invasion and a literature review.
Mohammad M, Schumacher K, Nayar R, Morton J
BMJ Case Rep 2020 Dec 21;13(12) doi: 10.1136/bcr-2020-234888. PMID: 33370937Free PMC Article
Clinicopahological features of superficial basaloid squamous cell carcinoma of the esophagus.
Oguma J, Ozawa S, Kazuno A, Nitta M, Ninomiya Y, Tomita S
Dis Esophagus 2017 Dec 1;30(12):1-5. doi: 10.1093/dote/dox076. PMID: 28881881
Review of ultrasound appearance in inflammatory breast cancer: A pictorial essay.
Abeywardhana DY, Nascimento VC, Dissanayake D, Taylor D, Metcalf C, Saunders C, Wylie E
J Med Imaging Radiat Oncol 2016 Feb;60(1):83-7. Epub 2015 Dec 2 doi: 10.1111/1754-9485.12418. PMID: 26631841
Primary pulmonary myoepithelial carcinoma.
Hysi I, Wattez H, Benhamed L, Porte H
Interact Cardiovasc Thorac Surg 2011 Aug;13(2):226-8. Epub 2011 May 30 doi: 10.1510/icvts.2011.270934. PMID: 21628324

Therapy

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study.
Skrede OJ, De Raedt S, Kleppe A, Hveem TS, Liestøl K, Maddison J, Askautrud HA, Pradhan M, Nesheim JA, Albregtsen F, Farstad IN, Domingo E, Church DN, Nesbakken A, Shepherd NA, Tomlinson I, Kerr R, Novelli M, Kerr DJ, Danielsen HE
Lancet 2020 Feb 1;395(10221):350-360. doi: 10.1016/S0140-6736(19)32998-8. PMID: 32007170
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Recurrent colorectal cancer after endoscopic resection when additional surgery was recommended.
Takatsu Y, Fukunaga Y, Hamasaki S, Ogura A, Nagata J, Nagasaki T, Akiyoshi T, Konishi T, Fujimoto Y, Nagayama S, Ueno M
World J Gastroenterol 2016 Feb 21;22(7):2336-41. doi: 10.3748/wjg.v22.i7.2336. PMID: 26900295Free PMC Article
Telomerase-specific oncolytic virotherapy for human gastrointestinal cancer.
Fujiwara T, Shirakawa Y, Kagawa S
Expert Rev Anticancer Ther 2011 Apr;11(4):525-32. doi: 10.1586/era.10.200. PMID: 21504319
The possible role of stromal cell stimulation in worsening the prognosis of a subset of patients with breast cancer.
Stewart TH, Tsai SC
Clin Exp Metastasis 1993 Jul;11(4):295-305. doi: 10.1007/BF00058049. PMID: 8319378

Prognosis

Patterns and Predictors of Metastatic Spread to the Neck in Pediatric Thyroid Carcinoma.
Propst EJ, Wasserman JD, Gorodensky J, Ngan BY, Wolter NE
Laryngoscope 2021 Mar;131(3):E1002-E1009. Epub 2020 Aug 1 doi: 10.1002/lary.28937. PMID: 32738066
A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: "eCura system".
Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakaya N, Nakamura T, Shimosegawa T
Am J Gastroenterol 2017 Jun;112(6):874-881. Epub 2017 Apr 11 doi: 10.1038/ajg.2017.95. PMID: 28397873
Primary pulmonary myoepithelial carcinoma.
Hysi I, Wattez H, Benhamed L, Porte H
Interact Cardiovasc Thorac Surg 2011 Aug;13(2):226-8. Epub 2011 May 30 doi: 10.1510/icvts.2011.270934. PMID: 21628324
Preservation of the anus in the therapy of distal rectal cancers.
Breen E, Bleday R
Surg Clin North Am 1997 Feb;77(1):71-83. doi: 10.1016/s0039-6109(05)70533-8. PMID: 9092118
Carcinoid tumors of the appendix.
Bowman GA, Rosenthal D
Am J Surg 1983 Dec;146(6):700-3. doi: 10.1016/0002-9610(83)90321-5. PMID: 6650751

Clinical prediction guides

Single-cell transcriptome analysis profiling lymphatic invasion-related TME in colorectal cancer.
Wang L, Ma L, Song Z, Zhou L, Chen K, Wang X, Liu Z, Wang B, Shen C, Guo X, Jia X
Sci Rep 2024 Apr 17;14(1):8911. doi: 10.1038/s41598-024-59656-6. PMID: 38632387Free PMC Article
Prognostic Significance of CONUT Score in Elderly NSCLC.
Tamura M, Sakai T, Furukawa N, Yamamoto M, Miyazaki R, Okada H
Ann Thorac Cardiovasc Surg 2024;30(1) doi: 10.5761/atcs.oa.24-00009. PMID: 38569836Free PMC Article
A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: "eCura system".
Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakaya N, Nakamura T, Shimosegawa T
Am J Gastroenterol 2017 Jun;112(6):874-881. Epub 2017 Apr 11 doi: 10.1038/ajg.2017.95. PMID: 28397873
Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer.
Nozoe T, Iguchi T, Adachi E, Matsukuma A, Ezaki T
Surg Today 2011 Apr;41(4):510-3. Epub 2011 Mar 23 doi: 10.1007/s00595-009-4297-x. PMID: 21431483
Lymphatic invasion in pigmented nevi.
Bell ME, Hill DP, Bhargava MK
Am J Clin Pathol 1979 Jul;72(1):97-100. doi: 10.1093/ajcp/72.1.97. PMID: 453117

Recent systematic reviews

Clinicopathological and prognostic features of colorectal mucinous adenocarcinomas: a systematic review and meta-analysis.
Wang X, Wang H, He H, Lv K, Yuan W, Chen J, Yang H
BMC Cancer 2024 Sep 19;24(1):1161. doi: 10.1186/s12885-024-12905-3. PMID: 39294609Free PMC Article
Differentiated high grade thyroid carcinomas: Diagnostic consideration and clinical features.
Tondi Resta I, Gubbiotti MA, Montone KT, Livolsi VA, Baloch ZW
Hum Pathol 2024 Feb;144:53-60. Epub 2024 Jan 19 doi: 10.1016/j.humpath.2024.01.002. PMID: 38244615
The prognostic impact of tumor-infiltrating B lymphocytes in patients with solid malignancies: A systematic review and meta-analysis.
Liu H, Li Z, Han X, Li Z, Zhao Y, Liu F, Zhu Z, Lv Y, Liu Z, Zhang N
Crit Rev Oncol Hematol 2023 Jan;181:103893. Epub 2022 Dec 5 doi: 10.1016/j.critrevonc.2022.103893. PMID: 36481308
Blood microvessel density, lymphatic microvessel density and lymphatic invasion in predicting melanoma metastases: systematic review and meta-analysis.
Pastushenko I, Vermeulen PB, Carapeto FJ, Van den Eynden G, Rutten A, Ara M, Dirix LY, Van Laere S
Br J Dermatol 2014 Jan;170(1):66-77. doi: 10.1111/bjd.12688. PMID: 24134623
CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis.
Chen S, Song X, Chen Z, Li X, Li M, Liu H, Li J
PLoS One 2013;8(2):e56380. Epub 2013 Feb 11 doi: 10.1371/journal.pone.0056380. PMID: 23409180Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...