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Classic medulloblastoma

MedGen UID:
353541
•Concept ID:
C1707400
•
Neoplastic Process
Synonyms: Classic Medulloblastoma; classic medulloblastoma
SNOMED CT: Classic medulloblastoma (699703008); Classic medulloblastoma (699704002)
 
Monarch Initiative: MONDO:0016712
Orphanet: ORPHA251867

Definition

Classic medulloblastoma is a histological variant of medulloblastoma (see this term) ,an embryonic malignancy, having a midline location, occurring most often in children and manifesting with variable symptoms such as headaches, nausea, vomiting and ataxia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic medulloblastoma

Professional guidelines

PubMed

Postponed is not canceled: role of craniospinal radiation therapy in the management of recurrent infant medulloblastoma--an experience from the HIT-REZ 1997 & 2005 studies.
Müller K, Mynarek M, Zwiener I, Siegler N, Zimmermann M, Christiansen H, Budach W, Henke G, Warmuth-Metz M, Pietsch T, von Hoff K, von Bueren A, Bode U, Rutkowski S, Kortmann RD, Fleischhack G, Tippelt S
Int J Radiat Oncol Biol Phys 2014 Apr 1;88(5):1019-24. doi: 10.1016/j.ijrobp.2014.01.013. PMID: 24661654
Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy.
Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JE, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J; German Pediatric Brain Tumor Study Group
Neuro Oncol 2009 Apr;11(2):201-10. Epub 2008 Sep 25 doi: 10.1215/15228517-2008-084. PMID: 18818397Free PMC Article
Cytomorphologic characteristics, differential diagnosis and utility during intraoperative consultation for medulloblastoma.
Takei H, Dauser RC, Adesina AM
Acta Cytol 2007 Mar-Apr;51(2):183-92. doi: 10.1159/000325713. PMID: 17425200

Recent clinical studies

Etiology

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing EJ, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider MJ, Dohmen H, Monoranu CM, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber NU, Grotzer M, Benesch M, Schlegel PG, Deinlein F, von Bueren AO, Friedrich C, Juhnke BO, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann RD, Kool M, Rutkowski S
J Clin Oncol 2020 Jun 20;38(18):2028-2040. Epub 2020 Apr 24 doi: 10.1200/JCO.19.03057. PMID: 32330099
Childhood Medulloblastoma Revisited.
Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z
Top Magn Reson Imaging 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. PMID: 30516696
Pathological and molecular heterogeneity of medulloblastoma.
Gulino A, Arcella A, Giangaspero F
Curr Opin Oncol 2008 Nov;20(6):668-75. doi: 10.1097/CCO.0b013e32831369f4. PMID: 18841049
Pale islands in medulloblastoma consist of differentiated cells with low growth potential.
Iijima M, Nakazato Y
Pathol Int 1997 Jan;47(1):25-30. doi: 10.1111/j.1440-1827.1997.tb04431.x. PMID: 9051689
"Desmoplastic" versus "classic" medulloblastoma: comparison of DNA content, histopathology and differentiation.
Giangaspero F, Chieco P, Ceccarelli C, Lisignoli G, Pozzuoli R, Gambacorta M, Rossi G, Burger PC
Virchows Arch A Pathol Anat Histopathol 1991;418(3):207-14. doi: 10.1007/BF01606058. PMID: 1900966

Diagnosis

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing EJ, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider MJ, Dohmen H, Monoranu CM, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber NU, Grotzer M, Benesch M, Schlegel PG, Deinlein F, von Bueren AO, Friedrich C, Juhnke BO, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann RD, Kool M, Rutkowski S
J Clin Oncol 2020 Jun 20;38(18):2028-2040. Epub 2020 Apr 24 doi: 10.1200/JCO.19.03057. PMID: 32330099
Childhood Medulloblastoma Revisited.
Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z
Top Magn Reson Imaging 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. PMID: 30516696
Distinctive MRI features of pediatric medulloblastoma subtypes.
Yeom KW, Mobley BC, Lober RM, Andre JB, Partap S, Vogel H, Barnes PD
AJR Am J Roentgenol 2013 Apr;200(4):895-903. doi: 10.2214/AJR.12.9249. PMID: 23521467
Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma.
Coco S, Valdora F, Bonassi S, Scaruffi P, Stigliani S, Oberthuer A, Berthold F, Andolfo I, Servidei T, Riccardi R, Basso E, Iolascon A, Tonini GP
OMICS 2011 May;15(5):273-80. Epub 2011 Feb 24 doi: 10.1089/omi.2010.0103. PMID: 21348762
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis.
Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J
J Clin Oncol 2010 Nov 20;28(33):4961-8. Epub 2010 Oct 12 doi: 10.1200/JCO.2010.30.2299. PMID: 20940197

Therapy

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing EJ, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider MJ, Dohmen H, Monoranu CM, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber NU, Grotzer M, Benesch M, Schlegel PG, Deinlein F, von Bueren AO, Friedrich C, Juhnke BO, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann RD, Kool M, Rutkowski S
J Clin Oncol 2020 Jun 20;38(18):2028-2040. Epub 2020 Apr 24 doi: 10.1200/JCO.19.03057. PMID: 32330099
Medulloblastoma in China: clinicopathologic analyses of SHH, WNT, and non-SHH/WNT molecular subgroups reveal different therapeutic responses to adjuvant chemotherapy.
Zhang ZY, Xu J, Ren Y, Li KK, Ng HK, Mao Y, Zhong P, Yao Y, Zhou LF
PLoS One 2014;9(6):e99490. Epub 2014 Jun 16 doi: 10.1371/journal.pone.0099490. PMID: 24932704Free PMC Article
Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors.
Rodriguez Gutierrez D, Awwad A, Meijer L, Manita M, Jaspan T, Dineen RA, Grundy RG, Auer DP
AJNR Am J Neuroradiol 2014 May;35(5):1009-15. Epub 2013 Dec 5 doi: 10.3174/ajnr.A3784. PMID: 24309122Free PMC Article
Tropism of the in situ growth from biopsies of childhood neuroectodermal tumors following transplantation into experimental teratoma.
Jamil S, Hultman I, Cedervall J, Ali RQ, Fuchs G, Gustavsson B, Asmundsson J, Sandstedt B, Kogner P, Ährlund-Richter L
Int J Cancer 2014 Apr 1;134(7):1630-7. Epub 2013 Oct 17 doi: 10.1002/ijc.28498. PMID: 24122295
Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy.
Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JE, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J; German Pediatric Brain Tumor Study Group
Neuro Oncol 2009 Apr;11(2):201-10. Epub 2008 Sep 25 doi: 10.1215/15228517-2008-084. PMID: 18818397Free PMC Article

Prognosis

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing EJ, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider MJ, Dohmen H, Monoranu CM, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber NU, Grotzer M, Benesch M, Schlegel PG, Deinlein F, von Bueren AO, Friedrich C, Juhnke BO, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann RD, Kool M, Rutkowski S
J Clin Oncol 2020 Jun 20;38(18):2028-2040. Epub 2020 Apr 24 doi: 10.1200/JCO.19.03057. PMID: 32330099
Distinctive MRI features of pediatric medulloblastoma subtypes.
Yeom KW, Mobley BC, Lober RM, Andre JB, Partap S, Vogel H, Barnes PD
AJR Am J Roentgenol 2013 Apr;200(4):895-903. doi: 10.2214/AJR.12.9249. PMID: 23521467
Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro.
Ma JX, Li H, Chen XM, Yang XH, Wang Q, Wu ML, Kong QY, Li ZX, Liu J
Neuropathology 2013 Feb;33(1):7-16. Epub 2012 Apr 27 doi: 10.1111/j.1440-1789.2012.01318.x. PMID: 22537175
p75(NTR) induces apoptosis in medulloblastoma cells.
Küchler J, Hartmann W, Waha A, Koch A, Endl E, Wurst P, Kindler D, Mikeska T, Waha A, Goodyer CG, Büttner R, Schilling K, Pietsch T
Int J Cancer 2011 Apr 15;128(8):1804-12. doi: 10.1002/ijc.25508. PMID: 20549701
Pathological and molecular heterogeneity of medulloblastoma.
Gulino A, Arcella A, Giangaspero F
Curr Opin Oncol 2008 Nov;20(6):668-75. doi: 10.1097/CCO.0b013e32831369f4. PMID: 18841049

Clinical prediction guides

Distinctive MRI features of pediatric medulloblastoma subtypes.
Yeom KW, Mobley BC, Lober RM, Andre JB, Partap S, Vogel H, Barnes PD
AJR Am J Roentgenol 2013 Apr;200(4):895-903. doi: 10.2214/AJR.12.9249. PMID: 23521467
Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro.
Ma JX, Li H, Chen XM, Yang XH, Wang Q, Wu ML, Kong QY, Li ZX, Liu J
Neuropathology 2013 Feb;33(1):7-16. Epub 2012 Apr 27 doi: 10.1111/j.1440-1789.2012.01318.x. PMID: 22537175
Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma.
Coco S, Valdora F, Bonassi S, Scaruffi P, Stigliani S, Oberthuer A, Berthold F, Andolfo I, Servidei T, Riccardi R, Basso E, Iolascon A, Tonini GP
OMICS 2011 May;15(5):273-80. Epub 2011 Feb 24 doi: 10.1089/omi.2010.0103. PMID: 21348762
Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy.
Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JE, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J; German Pediatric Brain Tumor Study Group
Neuro Oncol 2009 Apr;11(2):201-10. Epub 2008 Sep 25 doi: 10.1215/15228517-2008-084. PMID: 18818397Free PMC Article
"Desmoplastic" versus "classic" medulloblastoma: comparison of DNA content, histopathology and differentiation.
Giangaspero F, Chieco P, Ceccarelli C, Lisignoli G, Pozzuoli R, Gambacorta M, Rossi G, Burger PC
Virchows Arch A Pathol Anat Histopathol 1991;418(3):207-14. doi: 10.1007/BF01606058. PMID: 1900966

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