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Breast Tubular Adenoma

MedGen UID:
362754
•Concept ID:
C1879899
•
Neoplastic Process
Synonym: Tubular adenoma of breast
SNOMED CT: Tubular adenoma of breast (721597007)

Definition

A benign, well circumscribed neoplasm that arises from the breast. It is composed entirely of tubular structures that contain epithelial and myoepithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Tubular Adenoma

Professional guidelines

PubMed

Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment.
Kurian AW, Hare EE, Mills MA, Kingham KE, McPherson L, Whittemore AS, McGuire V, Ladabaum U, Kobayashi Y, Lincoln SE, Cargill M, Ford JM
J Clin Oncol 2014 Jul 1;32(19):2001-9. Epub 2014 Apr 14 doi: 10.1200/JCO.2013.53.6607. PMID: 24733792Free PMC Article
Differential diagnosis between sclerosing adenosis and tubular carcinoma of the breast under transmission and scanning electron microscope.
Baltatzis GE, Voloudakis GE, Arnogiannakis N, Misitzis J, Voloudakis-Baltatzis IE
Ultrastruct Pathol 2011 Oct;35(5):226-9. doi: 10.3109/01913123.2011.603460. PMID: 21910568
Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
Olgac S, Hutchinson B, Tickoo SK, Reuter VE
Mod Pathol 2006 Feb;19(2):218-24. doi: 10.1038/modpathol.3800520. PMID: 16424894

Recent clinical studies

Etiology

Tubular Adenoma of the Breast: Radiologic-Pathologic Correlation.
Joo GJ, Carter GJ, Berg WA
J Breast Imaging 2023 Nov 30;5(6):703-711. doi: 10.1093/jbi/wbad066. PMID: 38141235
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.
Volckmar AL, Leichsenring J, Flechtenmacher C, Pfarr N, Siebolts U, Kirchner M, Budczies J, Bockmayr M, Ridinger K, Lorenz K, Herpel E, Noske A, Weichert W, Klauschen F, Schirmacher P, Penzel R, Endris V, Stenzinger A
Genes Chromosomes Cancer 2017 Jan;56(1):11-17. Epub 2016 Aug 9 doi: 10.1002/gcc.22396. PMID: 27438523
Surgical treatment of the solid breast masses in female adolescents.
Ezer SS, Oguzkurt P, Ince E, Temiz A, Bolat FA, Hicsonmez A
J Pediatr Adolesc Gynecol 2013 Feb;26(1):31-5. Epub 2012 Nov 15 doi: 10.1016/j.jpag.2012.09.004. PMID: 23158756
Acromegaly and cancer.
Jenkins PJ
Horm Res 2004;62 Suppl 1:108-15. doi: 10.1159/000080768. PMID: 15761242

Diagnosis

Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Tubular adenomas of the breast: a rare diagnosis.
Miller MC, Johnson P, Kim S, Choi L
BMJ Case Rep 2018 Aug 27;2018 doi: 10.1136/bcr-2018-224631. PMID: 30150335Free PMC Article
Differential diagnosis between sclerosing adenosis and tubular carcinoma of the breast under transmission and scanning electron microscope.
Baltatzis GE, Voloudakis GE, Arnogiannakis N, Misitzis J, Voloudakis-Baltatzis IE
Ultrastruct Pathol 2011 Oct;35(5):226-9. doi: 10.3109/01913123.2011.603460. PMID: 21910568
Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review.
Oo KZ, Xiao PQ
Arch Pathol Lab Med 2009 Sep;133(9):1487-9. doi: 10.5858/133.9.1487. PMID: 19722761
Surgical breast lesions in adolescent patients and a review of the literature.
Sönmez K, Türkyilmaz Z, Karabulut R, Demiroğullari B, Ozen IO, Moralioğlu S, Başaklar AC, Kale N
Acta Chir Belg 2006 Jul-Aug;106(4):400-4. doi: 10.1080/00015458.2006.11679915. PMID: 17017692

Therapy

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Schmidt RL, Murugan P, Greene DN
Arch Pathol Lab Med 2022 Jan 2;146(2):252-261. doi: 10.5858/arpa.2020-0704-RA. PMID: 33983412
BCDnet: Parallel heterogeneous eight-class classification model of breast pathology.
He Q, Cheng G, Ju H
PLoS One 2021;16(7):e0253764. Epub 2021 Jul 12 doi: 10.1371/journal.pone.0253764. PMID: 34252112Free PMC Article
Colon metastases as first clinical manifestation of lobular breast carcinoma with no subsequent evidence of breast disease.
Abu Zaanona MI, Gulati A, Rowland K
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-236225. PMID: 33257365Free PMC Article
Risk of colorectal adenomas in women with prior breast cancer.
Shukla A, Shukla S, Osowo A, Mashtare T, Bhutani MS, Guha S
Dig Dis Sci 2012 Dec;57(12):3240-5. Epub 2012 Oct 12 doi: 10.1007/s10620-012-2432-9. PMID: 23065089
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
Vigushin DM, Ali S, Pace PE, Mirsaidi N, Ito K, Adcock I, Coombes RC
Clin Cancer Res 2001 Apr;7(4):971-6. PMID: 11309348

Prognosis

Tubular Adenoma of the Breast: Radiologic-Pathologic Correlation.
Joo GJ, Carter GJ, Berg WA
J Breast Imaging 2023 Nov 30;5(6):703-711. doi: 10.1093/jbi/wbad066. PMID: 38141235
Pediatric breast masses: an argument for observation.
McLaughlin CM, Gonzalez-Hernandez J, Bennett M, Piper HG
J Surg Res 2018 Aug;228:247-252. Epub 2018 Apr 12 doi: 10.1016/j.jss.2018.03.056. PMID: 29907218
Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.
Volckmar AL, Leichsenring J, Flechtenmacher C, Pfarr N, Siebolts U, Kirchner M, Budczies J, Bockmayr M, Ridinger K, Lorenz K, Herpel E, Noske A, Weichert W, Klauschen F, Schirmacher P, Penzel R, Endris V, Stenzinger A
Genes Chromosomes Cancer 2017 Jan;56(1):11-17. Epub 2016 Aug 9 doi: 10.1002/gcc.22396. PMID: 27438523
Differential diagnosis between sclerosing adenosis and tubular carcinoma of the breast under transmission and scanning electron microscope.
Baltatzis GE, Voloudakis GE, Arnogiannakis N, Misitzis J, Voloudakis-Baltatzis IE
Ultrastruct Pathol 2011 Oct;35(5):226-9. doi: 10.3109/01913123.2011.603460. PMID: 21910568
Infiltrating syringomatous adenoma of the nipple. A clinical and pathological study of 11 cases.
Jones MW, Norris HJ, Snyder RC
Am J Surg Pathol 1989 Mar;13(3):197-201. doi: 10.1097/00000478-198903000-00003. PMID: 2919717

Clinical prediction guides

Convolution Neural Network for Breast Cancer Detection and Classification Using Deep Learning.
Abunasser BS, Al-Hiealy MRJ, Zaqout IS, Abu-Naser SS
Asian Pac J Cancer Prev 2023 Feb 1;24(2):531-544. doi: 10.31557/APJCP.2023.24.2.531. PMID: 36853302Free PMC Article
Pediatric breast masses: an argument for observation.
McLaughlin CM, Gonzalez-Hernandez J, Bennett M, Piper HG
J Surg Res 2018 Aug;228:247-252. Epub 2018 Apr 12 doi: 10.1016/j.jss.2018.03.056. PMID: 29907218
Giant tubular adenoma of the accessory breast in the anterior chest wall occurred in a pregnant woman.
Huang Y, Zhang H, Zhou Q, Ling L, Wang S
Diagn Pathol 2015 Jun 4;10:60. doi: 10.1186/s13000-015-0286-0. PMID: 26040320Free PMC Article
Surgical breast lesions in adolescent patients and a review of the literature.
Sönmez K, Türkyilmaz Z, Karabulut R, Demiroğullari B, Ozen IO, Moralioğlu S, Başaklar AC, Kale N
Acta Chir Belg 2006 Jul-Aug;106(4):400-4. doi: 10.1080/00015458.2006.11679915. PMID: 17017692
Adenomas of the breast and ectopic breast under lactational influences.
O'Hara MF, Page DL
Hum Pathol 1985 Jul;16(7):707-12. doi: 10.1016/s0046-8177(85)80156-8. PMID: 4007846

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Schmidt RL, Murugan P, Greene DN
Arch Pathol Lab Med 2022 Jan 2;146(2):252-261. doi: 10.5858/arpa.2020-0704-RA. PMID: 33983412

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