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Sweat Gland Tubular Carcinoma

MedGen UID:
365243
•Concept ID:
C1883403
•
Neoplastic Process
Synonym: Sweat Gland Tubular Adenocarcinoma

Definition

An aggressive adenocarcinoma that arises from the sweat glands. It usually presents as a firm, erythematous nodular lesion in the axilla. Morphologically, it is characterized by the presence of tubular structures and apocrine differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSweat Gland Tubular Carcinoma

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277
Ceruminous adenocarcinoma of the external auditory canal- report of a rare case with a discussion of its differential diagnoses.
Singh VY, Sarangi S, Agrawal K
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):424-426. doi: 10.4103/IJPM.IJPM_326_20. PMID: 33851654
A Modern Approach to Differential Diagnosis Between Cutaneous Apocrine Carcinoma and Metastasis From Breast Carcinoma.
Fernandez-Flores A
Am J Dermatopathol 2016 Feb;38(2):162-4. doi: 10.1097/DAD.0000000000000302. PMID: 26825162

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Eccrine Porocarcinoma: Avoiding Diagnostic Delay.
Jarocki C, Kozlow J, Harms PW, Schmidt BM
Foot Ankle Spec 2020 Oct;13(5):415-419. Epub 2020 Aug 17 doi: 10.1177/1938640020946190. PMID: 32924585
Metastatic eccrine porocarcinoma.
Rehal B, Merin MR, Barr K
Cutis 2013 Aug;92(2):67-70. PMID: 24087778
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446
Extramammary Paget's disease.
Mehta NJ, Torno R, Sorra T
South Med J 2000 Jul;93(7):713-5. PMID: 10923963

Diagnosis

Hidradenocarcinoma.
de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Tender finger nodule.
Klapperich ME, Buhalog BA, Hinshaw MA
Dermatol Online J 2018 Apr 15;24(4) PMID: 29906012
Extramammary Paget's disease.
Mehta NJ, Torno R, Sorra T
South Med J 2000 Jul;93(7):713-5. PMID: 10923963
Epidermotropic eccrine porocarcinoma.
Landa NG, Winkelmann RK
J Am Acad Dermatol 1991 Jan;24(1):27-31. doi: 10.1016/0190-9622(91)70004-l. PMID: 1999525

Therapy

Photodynamic therapy for extramammary Paget's disease: A systematic review of the literature.
Shim PJ, Zeitouni NC
Photodiagnosis Photodyn Ther 2020 Sep;31:101911. Epub 2020 Jul 6 doi: 10.1016/j.pdpdt.2020.101911. PMID: 32645437
Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab.
Lee KA, Cioni M, Robson A, Bataille V
BMJ Case Rep 2019 Sep 5;12(9) doi: 10.1136/bcr-2018-228917. PMID: 31492726Free PMC Article
Overlooked adenocarcinoma of the scalp.
Elefteriou-Kokolis E, Danielsen R, Kokolis RN
JAAPA 2018 Dec;31(12):27-28. doi: 10.1097/01.JAA.0000545067.78849.80. PMID: 30489387
Post-brachytherapy wound.
Gardner S
Br J Nurs 2017 Nov 8;26(Sup20a):S16-S17. doi: 10.12968/bjon.2017.26.Sup20a.S16. PMID: 29144783
Rara avis.
Bruno MS, Ober WB
N Y State J Med 1971 Apr 15;71(8):865-71. PMID: 5279355

Prognosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Metastatic eccrine porocarcinoma.
Rehal B, Merin MR, Barr K
Cutis 2013 Aug;92(2):67-70. PMID: 24087778
Syringocystadenocarcinoma papilliferum of the eyelid.
Hoguet AS, Dolphin K, McCormick SA, Milman T
Ophthalmic Plast Reconstr Surg 2012 Jan-Feb;28(1):e27-9. doi: 10.1097/IOP.0b013e318216366a. PMID: 22266788
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446
Extramammary Paget's disease.
Mehta NJ, Torno R, Sorra T
South Med J 2000 Jul;93(7):713-5. PMID: 10923963

Clinical prediction guides

Nectin-4 expression in a subset of cutaneous adnexal carcinomas: A potential target for therapy with enfortumab vedotin.
Cho WC, Saade R, Nagarajan P, Aung PP, Milton DR, Marques-Piubelli ML, Hudgens C, Ledesma D, Nelson K, Ivan D, Zhang M, Torres-Cabala CA, Campbell M, Alhalabi O, Prieto VG, Wistuba II, Esmaeli B, Curry JL
J Cutan Pathol 2024 May;51(5):360-367. Epub 2024 Jan 10 doi: 10.1111/cup.14579. PMID: 38200650
Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811
Microcystic adnexal carcinoma: review of 51 Japanese patients.
Ohtsuka H, Nagamatsu S
Dermatology 2002;204(3):190-3. doi: 10.1159/000057880. PMID: 12037446

Recent systematic reviews

Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review.
Bienstman T, Güvenç C, Garmyn M
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115760. PMID: 38891945Free PMC Article
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Photodynamic therapy for extramammary Paget's disease: A systematic review of the literature.
Shim PJ, Zeitouni NC
Photodiagnosis Photodyn Ther 2020 Sep;31:101911. Epub 2020 Jul 6 doi: 10.1016/j.pdpdt.2020.101911. PMID: 32645437
Cylindroma of head and neck: review of the literature and report of two rare cases.
Singh DD, Naujoks C, Depprich R, Schulte KW, Jankowiak F, Kübler NR, Handschel J
J Craniomaxillofac Surg 2013 Sep;41(6):516-21. Epub 2012 Dec 21 doi: 10.1016/j.jcms.2012.11.016. PMID: 23260808

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