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Sweat gland carcinoma

MedGen UID:
234685
•Concept ID:
C1412016
•
Neoplastic Process
Synonyms: Carcinoma of Sweat Gland; carcinoma of sweat gland; Carcinoma of the Sweat Gland; carcinoma of the sweat gland; carcinoma, sweat gland, malignant; Sweat Gland Adenocarcinoma; Sweat Gland Carcinoma; sweat gland carcinoma; sweat gland carcinoma/apocrine eccrine carcinoma
SNOMED CT: Sweat gland carcinoma (254707006); Sweat gland carcinoma (32272007)
 
Monarch Initiative: MONDO:0005524

Definition

A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma. [from NCI]

Professional guidelines

PubMed

Cutaneous Sweat Gland Carcinomas with Basaloid Differentiation: An Update with Emphasis on Differential Diagnoses.
Flux K, Brenn T
Clin Lab Med 2017 Sep;37(3):587-601. Epub 2017 Jun 9 doi: 10.1016/j.cll.2017.05.006. PMID: 28802502
Adamantinoma of the pretibial soft tissue. Clinicopathologic features, differential diagnosis, and possible relationship to intraosseous disease.
Mills SE, Rosai J
Am J Clin Pathol 1985 Jan;83(1):108-14. doi: 10.1093/ajcp/83.1.108. PMID: 3966430

Recent clinical studies

Etiology

Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Endocrine Mucin-Producing Sweat Gland Carcinoma in an Elderly Man.
Shah S, Parekh P, Rodriguez M
Am J Dermatopathol 2020 Feb;42(2):153-155. doi: 10.1097/DAD.0000000000001442. PMID: 31995546
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Chemotherapy of metastatic sweat gland carcinoma. A retrospective review.
Coonley CJ, Schauer P, Kelsen DP, Sordillo P, Huvos AG
Am J Clin Oncol 1985 Aug;8(4):307-11. doi: 10.1097/00000421-198508000-00006. PMID: 3909802
Sweat gland carcinoma.
Hirsh LF, Enterline HT, Rosato EF, Rosato FE
Ann Surg 1971 Aug;174(2):283-6. doi: 10.1097/00000658-197108000-00015. PMID: 5560851Free PMC Article

Diagnosis

TRPS1 Expression in Endocrine Mucin-Producing Sweat Gland Carcinoma: Diagnostic Utility and Pitfalls.
Liu YA, Cho WC
Am J Dermatopathol 2024 Feb 1;46(2):133-135. Epub 2023 Dec 6 doi: 10.1097/DAD.0000000000002594. PMID: 38055965
Metastatic human papillomavirus-positive oropharyngeal carcinoma mimicking primary cutaneous sweat-gland carcinoma.
Lilly AJ, Blumberg JM, Smith SV, Googe PB, Miedema JR
J Cutan Pathol 2021 Jun;48(6):818-820. Epub 2021 Feb 9 doi: 10.1111/cup.13962. PMID: 33442919
Malignant Sweat Gland Tumors.
Ahn CS, Sangüeza OP
Hematol Oncol Clin North Am 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002. PMID: 30497677
Epidermotropic eccrine porocarcinoma.
Landa NG, Winkelmann RK
J Am Acad Dermatol 1991 Jan;24(1):27-31. doi: 10.1016/0190-9622(91)70004-l. PMID: 1999525
Sweat gland carcinoma.
Rothman D, Damien N
J Med Soc N J 1979 Jun;76(6):433-4. PMID: 287812

Therapy

Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal Carcinoma, and Porocarcinoma.
Harms PW, Runge M, Chan MP, Liu CJ, Qin Z, Worden F, Robinson DR, Chinnaiyan AM, Mclean SA, Harms KL, Fullen DR, Patel RM, Andea AA, Udager AM
Mod Pathol 2024 Nov;37(11):100592. Epub 2024 Aug 21 doi: 10.1016/j.modpat.2024.100592. PMID: 39154783Free PMC Article
FIGHT-102: A phase 1 study of pemigatinib in Japanese patients with advanced malignancies.
Fujiwara Y, Kuboki Y, Furukawa M, Mizuno N, Hara H, Ioka T, Ueno M, Takahashi Y, Takahashi S, Takeuchi S, Lihou C, Ji T, Tian C, Shimizu T
Cancer Med 2023 May;12(9):10597-10611. Epub 2023 Mar 31 doi: 10.1002/cam4.5798. PMID: 37000035Free PMC Article
Eccrine sweat gland carcinoma: a case report and review of diagnosis and treatment.
Voutsadakis IA, Bruckner HW
Conn Med 2000 May;64(5):263-6. PMID: 10860232
Sustained complete remission of metastatic sweat gland carcinoma following regional hyperthermic perfusion.
Briscoe KE, Grage T, Kennedy BJ
JAMA 1978 Jul 7;240(1):51-2. PMID: 660813
Sweat gland carcinoma arising in irradiated skin.
el-Domeiri AA, Huvos AG, Beattie EJ Jr
Am J Roentgenol Radium Ther Nucl Med 1972 Mar;114(3):606-9. doi: 10.2214/ajr.114.3.606. PMID: 5011405

Prognosis

Endocrine Mucin-Producing Sweat Gland Carcinoma in an Elderly Man.
Shah S, Parekh P, Rodriguez M
Am J Dermatopathol 2020 Feb;42(2):153-155. doi: 10.1097/DAD.0000000000001442. PMID: 31995546
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Sweat gland carcinoma of the vulva.
Minagawa Y, Kigawa J, Terakawa N, Matsui K
Acta Obstet Gynecol Scand 1995 Aug;74(7):577-9. doi: 10.3109/00016349509024395. PMID: 7618462
Sweat gland carcinoma.
Hirsh LF, Enterline HT, Rosato EF, Rosato FE
Ann Surg 1971 Aug;174(2):283-6. doi: 10.1097/00000658-197108000-00015. PMID: 5560851Free PMC Article

Clinical prediction guides

NECTIN4 expression in sebaceous and sweat gland carcinoma.
Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909
Endocrine Mucin-Producing Sweat Gland Carcinoma: Emerging Evidence of Multicentric Cutaneous Origin and Occasional Concurrence With Analogous Breast Tumors.
Ravi PY, Walsh NM, Archibald C, Pasternak S
Am J Dermatopathol 2022 May 1;44(5):321-326. doi: 10.1097/DAD.0000000000002132. PMID: 35170475
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature.
Shen J, Pan X, Lu Y, Pan D, Ma Y, Zhan R
BMC Surg 2019 Oct 10;19(1):142. doi: 10.1186/s12893-019-0595-4. PMID: 31601219Free PMC Article
Chemotherapy of metastatic sweat gland carcinoma. A retrospective review.
Coonley CJ, Schauer P, Kelsen DP, Sordillo P, Huvos AG
Am J Clin Oncol 1985 Aug;8(4):307-11. doi: 10.1097/00000421-198508000-00006. PMID: 3909802

Recent systematic reviews

Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

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