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Susceptibility to coronavirus 229e(HCVS; CVS)

MedGen UID:
377700
•Concept ID:
C1852539
•
Finding
Synonym: Human coronavirus sensitivity
 
HPO: HP:0005396
OMIM®: 122460

Definition

Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e. [from HPO]

Clinical features

From HPO
Susceptibility to coronavirus 229e
MedGen UID:
377700
•Concept ID:
C1852539
•
Finding
Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSusceptibility to coronavirus 229e

Conditions with this feature

Susceptibility to coronavirus 229e
MedGen UID:
377700
•Concept ID:
C1852539
•
Finding
Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e.
See: Condition Record
Susceptibility to coronavirus 229e

Recent clinical studies

Etiology

Differential regulation of viral entry-associated genes modulated by inflammatory cytokines in the nasal epithelium.
Noh HE, Rha MS, Jeong Y, Kim D, Seo JH, Kang M, Moon UY, Kim CH, Cho HJ
J Med Virol 2024 Sep;96(9):e29913. doi: 10.1002/jmv.29913. PMID: 39257039
Quantifying the Individual Variation in Susceptibility to Endemic Coronavirus and SARS-CoV-2 with Human Challenge Trials.
Miura F, Klinkenberg D, Wallinga J
Epidemiology 2024 Jan 1;35(1):113-117. Epub 2023 Nov 27 doi: 10.1097/EDE.0000000000001679. PMID: 38032803Free PMC Article
Complicating Infections Associated with Common Endemic Human Respiratory Coronaviruses.
Cimolai N
Health Secur 2021 Mar-Apr;19(2):195-208. Epub 2020 Nov 11 doi: 10.1089/hs.2020.0067. PMID: 33186086
Comparing Clinical Characteristics of Influenza and Common Coronavirus Infections Using Electronic Health Records.
Li D, Wolk DM, Cantor MN
J Infect Dis 2021 Jun 4;223(11):1879-1886. doi: 10.1093/infdis/jiaa626. PMID: 33011809Free PMC Article
Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials.
Warnes SL, Little ZR, Keevil CW
mBio 2015 Nov 10;6(6):e01697-15. doi: 10.1128/mBio.01697-15. PMID: 26556276Free PMC Article

Diagnosis

Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor.
Weil T, Lawrenz J, Seidel A, Münch J, Müller JA
Antiviral Res 2022 Jul;203:105343. Epub 2022 May 19 doi: 10.1016/j.antiviral.2022.105343. PMID: 35598779Free PMC Article
Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation.
Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC, Yuen KY
J Infect Dis 2013 Jun 1;207(11):1743-52. Epub 2013 Mar 26 doi: 10.1093/infdis/jit123. PMID: 23532101Free PMC Article
Development of a nucleocapsid-based human coronavirus immunoassay and estimates of individuals exposed to coronavirus in a U.S. metropolitan population.
Severance EG, Bossis I, Dickerson FB, Stallings CR, Origoni AE, Sullens A, Yolken RH, Viscidi RP
Clin Vaccine Immunol 2008 Dec;15(12):1805-10. Epub 2008 Oct 22 doi: 10.1128/CVI.00124-08. PMID: 18945884Free PMC Article
Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients.
Gerna G, Campanini G, Rovida F, Percivalle E, Sarasini A, Marchi A, Baldanti F
J Med Virol 2006 Jul;78(7):938-49. doi: 10.1002/jmv.20645. PMID: 16721849Free PMC Article
Coronavirus 229E susceptibility in man-mouse hybrids is located on human chromosome 15.
Sakaguchi AY, Shows TB
Somatic Cell Genet 1982 Jan;8(1):83-94. doi: 10.1007/BF01538652. PMID: 6285532Free PMC Article

Therapy

Seasonal human coronavirus humoral responses in AZD1222 (ChaAdOx1 nCoV-19) COVID-19 vaccinated adults reveal limited cross-immunity.
Stanley AM, Aksyuk AA, Wilkins D, Green JA, Lan D, Shoemaker K, Tieu HV, Sobieszczyk ME, Falsey AR, Kelly EJ
Front Immunol 2024;15:1401728. Epub 2024 May 17 doi: 10.3389/fimmu.2024.1401728. PMID: 38827749Free PMC Article
Immunosuppressants exert differential effects on pan-coronavirus infection and distinct combinatory antiviral activity with molnupiravir and nirmatrelvir.
Wang Y, Li P, Lavrijsen M, Rottier RJ, den Hoed CM, Bruno MJ, Kamar N, Peppelenbosch MP, de Vries AC, Pan Q
United European Gastroenterol J 2023 Jun;11(5):431-447. Epub 2023 May 25 doi: 10.1002/ueg2.12417. PMID: 37226653Free PMC Article
Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients.
Lee KH, Yoo SG, Cho Y, Kwon DE, La Y, Han SH, Kim MS, Choi JS, Kim SI, Kim YS, Min YH, Cheong JW, Kim JS, Song YG
J Microbiol Immunol Infect 2021 Apr;54(2):253-260. Epub 2019 Jun 19 doi: 10.1016/j.jmii.2019.05.007. PMID: 31262511Free PMC Article
Why the lower reported prevalence of asthma in patients diagnosed with COVID-19 validates repurposing EDTA solutions to prevent and manage treat COVID-19 disease.
Cashman DP
Med Hypotheses 2020 Nov;144:110027. Epub 2020 Jun 26 doi: 10.1016/j.mehy.2020.110027. PMID: 32758873Free PMC Article

Prognosis

Potential CD8+ T Cell Cross-Reactivity Against SARS-CoV-2 Conferred by Other Coronavirus Strains.
Lee CH, Pinho MP, Buckley PR, Woodhouse IB, Ogg G, Simmons A, Napolitani G, Koohy H
Front Immunol 2020;11:579480. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.579480. PMID: 33250893Free PMC Article

Clinical prediction guides

Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination.
Amanat F, Clark J, Carreño JM, Strohmeier S, Yellin T, Meade PS, Bhavsar D, Muramatsu H, Sun W, Coughlan L, Pardi N, Krammer F
J Virol 2023 Mar 30;97(3):e0166422. Epub 2023 Feb 13 doi: 10.1128/jvi.01664-22. PMID: 36779758Free PMC Article
Photodynamic Inactivation of Human Coronaviruses.
Duguay BA, Herod A, Pringle ES, Monro SMA, Hetu M, Cameron CG, McFarland SA, McCormick C
Viruses 2022 Jan 8;14(1) doi: 10.3390/v14010110. PMID: 35062314Free PMC Article
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.
Li W, Luo R, He Q, van Kuppeveld FJM, Rottier PJM, Bosch BJ
Virus Res 2017 May 2;235:6-13. Epub 2017 Mar 28 doi: 10.1016/j.virusres.2017.03.018. PMID: 28363778Free PMC Article
Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials.
Warnes SL, Little ZR, Keevil CW
mBio 2015 Nov 10;6(6):e01697-15. doi: 10.1128/mBio.01697-15. PMID: 26556276Free PMC Article
Psychological stress and susceptibility to the common cold.
Cohen S, Tyrrell DA, Smith AP
N Engl J Med 1991 Aug 29;325(9):606-12. doi: 10.1056/NEJM199108293250903. PMID: 1713648

Supplemental Content

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