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Precursor Cell Lymphoblastic Leukemia-Lymphoma(ALL)

MedGen UID:
409528
•Concept ID:
C1961102
•
Neoplastic Process
Synonyms: Acute Lymphoblastic Leukemia; Acute Lymphocytic Leukemia; Acute Lymphoid Leukemia; Leukemia, Acute Lymphoblastic; Leukemia, Acute Lymphocytic; Leukemia, Acute Lymphoid; Leukemia, Lymphoblastic; Leukemia, Lymphoblastic, Acute; Leukemia, Lymphocytic, Acute; Leukemia, Lymphoid, Acute; Lymphoblastic Leukemia; Lymphoblastic Leukemia, Acute; Lymphoblastic Lymphoma; Lymphocytic Leukemia, Acute; Lymphoid Leukemia, Acute; Lymphoma, Lymphoblastic; Precursor Cell Lymphoblastic Leukemia Lymphoma
SNOMED CT: Precursor cell lymphoblastic leukemia, not phenotyped (128822004); Acute lymphoblastic leukemia, precursor-cell type (128822004); Precursor cell lymphoblastic leukemia (128822004); Acute lymphoid leukemia (128822004)
 
OMIM®: 613065

Definition

A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. [from MeSH]

Professional guidelines

PubMed

The Effect of Hematopoietic Stem Cell Transplantation on Treatment Outcome in Children with Acute Lymphoblastic Leukemia.
Ju HY, Lee NH, Yi ES, Choi YB, Kim SJ, Hyun JK, Cho HW, Lee JK, Lee JW, Sung KW, Koo HH, Yoo KH
Cancer Res Treat 2025 Jan;57(1):240-249. Epub 2024 Jul 5 doi: 10.4143/crt.2024.155. PMID: 38965922Free PMC Article

Recent clinical studies

Etiology

Recent Advances in Managing Acute Lymphoblastic Leukemia.
DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker?
Stanulla M, Cavé H, Moorman AV
Blood 2020 Jan 23;135(4):252-260. doi: 10.1182/blood.2019000813. PMID: 31821407Free PMC Article
Biology of childhood acute lymphoblastic leukemia.
Bhojwani D, Yang JJ, Pui CH
Pediatr Clin North Am 2015 Feb;62(1):47-60. doi: 10.1016/j.pcl.2014.09.004. PMID: 25435111Free PMC Article
Treatment of acute lymphoblastic leukemia.
Pui CH, Evans WE
N Engl J Med 2006 Jan 12;354(2):166-78. doi: 10.1056/NEJMra052603. PMID: 16407512

Diagnosis

Incorrigible inflammation.
Ariffin H
Br J Haematol 2024 Nov;205(5):1679-1680. Epub 2024 Sep 12 doi: 10.1111/bjh.19773. PMID: 39267309
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
IKZF1 deletions in pediatric acute lymphoblastic leukemia: still a poor prognostic marker?
Stanulla M, Cavé H, Moorman AV
Blood 2020 Jan 23;135(4):252-260. doi: 10.1182/blood.2019000813. PMID: 31821407Free PMC Article
Acute lymphoblastic leukemia.
Harrison CJ
Clin Lab Med 2011 Dec;31(4):631-47, ix. Epub 2011 Oct 6 doi: 10.1016/j.cll.2011.08.016. PMID: 22118741

Therapy

How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Immunotherapy in pediatric acute lymphoblastic leukemia.
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Mechanisms of resistance to CAR T cell therapy.
Shah NN, Fry TJ
Nat Rev Clin Oncol 2019 Jun;16(6):372-385. doi: 10.1038/s41571-019-0184-6. PMID: 30837712Free PMC Article
Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia.
Kantarjian HM, DeAngelo DJ, Stelljes M, Martinelli G, Liedtke M, Stock W, Gökbuget N, O'Brien S, Wang K, Wang T, Paccagnella ML, Sleight B, Vandendries E, Advani AS
N Engl J Med 2016 Aug 25;375(8):740-53. Epub 2016 Jun 12 doi: 10.1056/NEJMoa1509277. PMID: 27292104Free PMC Article
Clofarabine.
Pui CH, Jeha S
Nat Rev Drug Discov 2005 May;Suppl:S12-3. doi: 10.1038/nrd1724. PMID: 15962525

Prognosis

Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001.
Vrooman LM, Blonquist TM, Stevenson KE, Supko JG, Hunt SK, Cronholm SM, Koch V, Kay-Green S, Athale UH, Clavell LA, Cole PD, Harris MH, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Place AE, Schorin MA, Welch JJG, Neuberg DS, Sallan SE, Silverman LB
J Clin Oncol 2021 Nov 1;39(31):3496-3505. Epub 2021 Jul 6 doi: 10.1200/JCO.20.03692. PMID: 34228505
Can we prevent childhood Leukaemia?
Greaves M, Cazzaniga V, Ford A
Leukemia 2021 May;35(5):1258-1264. Epub 2021 Apr 9 doi: 10.1038/s41375-021-01211-7. PMID: 33833382Free PMC Article
Acute lymphoblastic leukemia.
Chang JH, Poppe MM, Hua CH, Marcus KJ, Esiashvili N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28371. doi: 10.1002/pbc.28371. PMID: 33818880
Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, Parasole R, Linderkamp C, Flotho C, Petit A, Micalizzi C, Mergen N, Mohammad A, Kormany WN, Eckert C, Möricke A, Sartor M, Hrusak O, Peters C, Saha V, Vinti L, von Stackelberg A
JAMA 2021 Mar 2;325(9):843-854. doi: 10.1001/jama.2021.0987. PMID: 33651091Free PMC Article
Acute Lymphoblastic Leukemia in Children.
Hunger SP, Mullighan CG
N Engl J Med 2015 Oct 15;373(16):1541-52. doi: 10.1056/NEJMra1400972. PMID: 26465987

Clinical prediction guides

Genome-wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia.
Zhu Q, Nambiar R, Schultz E, Gao X, Liang S, Flamand Y, Stevenson K, Cole PD, Gennarini L, Harris MH, Kahn JM, Ladas EJ, Athale UH, Hoa Tran T, Michon B, Welch JJG, Sallan SE, Silverman LB, Kelly KM, Yao S
Br J Haematol 2024 Nov;205(5):1889-1898. Epub 2024 Aug 14 doi: 10.1111/bjh.19696. PMID: 39143423Free PMC Article
Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis.
Zhang Y, Wang S, Zhang J, Liu C, Li X, Guo W, Duan Y, Chen X, Zong S, Zheng J, Wu Y, Chen X, Cheng X, Chang Y, Wang Y, Ding F, Yang W, Chen X, Guo Y, Zhang L, Chen Y, Zou Y, Zhu X, Gu J, Cheng T
Nat Cell Biol 2022 Feb;24(2):242-252. Epub 2022 Feb 10 doi: 10.1038/s41556-021-00814-7. PMID: 35145224
Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874Free PMC Article
The clinical relevance of detection of minimal residual disease in childhood acute lymphoblastic leukaemia.
Moppett J, Burke GA, Steward CG, Oakhill A, Goulden NJ
J Clin Pathol 2003 Apr;56(4):249-53. doi: 10.1136/jcp.56.4.249. PMID: 12663634Free PMC Article
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES
Science 1999 Oct 15;286(5439):531-7. doi: 10.1126/science.286.5439.531. PMID: 10521349

Recent systematic reviews

Comparison of blinatumomab and CAR T-cell therapy in relapsed/refractory acute lymphoblastic leukemia: a systematic review and meta-analysis.
Zhai Y, Hong J, Wang J, Jiang Y, Wu W, Lv Y, Guo J, Tian L, Sun H, Li Y, Li C, Zhan H, Zhao Z
Expert Rev Hematol 2024 Jan-Mar;17(1-3):67-76. Epub 2024 Jan 4 doi: 10.1080/17474086.2023.2298732. PMID: 38135295
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systematic review.
Coombs A, Schilperoort H, Sargent B
Crit Rev Oncol Hematol 2020 Aug;152:103004. Epub 2020 May 27 doi: 10.1016/j.critrevonc.2020.103004. PMID: 32580035Free PMC Article
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292

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