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Left Main Coronary Artery Stenosis

MedGen UID:: 412158
•Concept ID:: C2062905
•: Disease or Syndrome

Definition

Percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLeft Main Coronary Artery Stenosis

Abnormal cardiovascular system morphology
- Abnormal vascular morphology
  - Abnormal blood vessel morphology
    - Abnormal systemic arterial morphology
      - Abnormal coronary artery morphology
        Coronary artery stenosis
        Left Main Coronary Artery Stenosis
        Left Main Coronary Artery Stenosis, Percentage

Professional guidelines

PubMed

Left main coronary artery disease: pathophysiology, diagnosis, and treatment.

Collet C, Capodanno D, Onuma Y, Banning A, Stone GW, Taggart DP, Sabik J, Serruys PW
Nat Rev Cardiol 2018 Jun;15(6):321-331. doi: 10.1038/s41569-018-0001-4. PMID: 29599504

Left main coronary artery stenosis: severity evaluation and implications for management.

Habibi SE, Shah R, Berzingi CO, Melchior R, Sumption KF, Jovin IS
Expert Rev Cardiovasc Ther 2017 Mar;15(3):157-163. Epub 2017 Feb 24 doi: 10.1080/14779072.2017.1294065. PMID: 28256180

Treatment of unprotected left main coronary artery stenosis in the drug-eluting stent era.

Tanigawa J, Sutaria N, Goktekin O, Di Mario C
J Interv Cardiol 2005 Dec;18(6):455-65. doi: 10.1111/j.1540-8183.2005.00086.x. PMID: 16336426

See all (16)

Recent clinical studies

Etiology

Critical Left Main Coronary Stenosis After Sutureless Aortic Valve Replacement.

Chi WK, So CY, Chui KL, Chan JYS, Chan CY
J Invasive Cardiol 2020 Jun;32(6):E170-E171. doi: 10.25270/jic/19.00391. PMID: 32479420

Evolution of our understanding of the aVR sign.

Gibbs MA, Leedekerken JB, Littmann L
J Electrocardiol 2019 Sep-Oct;56:121-124. Epub 2019 Aug 1 doi: 10.1016/j.jelectrocard.2019.07.014. PMID: 31401390

Left main coronary artery disease: pathophysiology, diagnosis, and treatment.

Collet C, Capodanno D, Onuma Y, Banning A, Stone GW, Taggart DP, Sabik J, Serruys PW
Nat Rev Cardiol 2018 Jun;15(6):321-331. doi: 10.1038/s41569-018-0001-4. PMID: 29599504

Critical left main coronary artery stenosis identified by colour Doppler screening during pre-exercise stress echocardiogram.

Tait J, Ashton T
Can J Cardiol 2011 May-Jun;27(3):390.e13-4. doi: 10.1016/j.cjca.2010.12.055. PMID: 21601777

Treatment of unprotected left main coronary artery stenosis with a drug eluting stent in a heart transplant patient with allograft vasculopathy.

Matos G, Steen L, Leya F
Heart 2005 Feb;91(2):e11. doi: 10.1136/hrt.2004.045096. PMID: 15657201 Free PMC Article

See all (252)

Diagnosis

Assessment of left main coronary artery disease: a comparison between invasive and noninvasive.

Alalawi LH, Dookhan CM, Verghese D, Manubolu VS, Aldana-Bitar J, Lakshmanan S, Ahmad K, Shafter A, Alchokhachi Z, Ghanem A, Golub IS, Budoff M, Roy S
Coron Artery Dis 2022 Sep 1;33(6):490-498. Epub 2022 Jun 22 doi: 10.1097/MCA.0000000000001154. PMID: 35757932

Critical left main coronary artery stenosis in a patient with homozygous familial hypercholesterolemia and aortic valve replacement.

Köse N, Kırat T, Ergün G, Altun İ, Akın F
Turk Kardiyol Dern Ars 2021 Sep;49(6):512. doi: 10.5543/tkda.2021.79137. PMID: 34523601

Critical Left Main Coronary Stenosis After Sutureless Aortic Valve Replacement.

Chi WK, So CY, Chui KL, Chan JYS, Chan CY
J Invasive Cardiol 2020 Jun;32(6):E170-E171. doi: 10.25270/jic/19.00391. PMID: 32479420

Left main coronary artery disease: pathophysiology, diagnosis, and treatment.

Collet C, Capodanno D, Onuma Y, Banning A, Stone GW, Taggart DP, Sabik J, Serruys PW
Nat Rev Cardiol 2018 Jun;15(6):321-331. doi: 10.1038/s41569-018-0001-4. PMID: 29599504

Left main coronary artery stenosis due to a protruding calcified nodule.

Triantafyllis AS, McCutcheon K, Adriaenssens T, Bennett J
Acta Cardiol 2018 Apr;73(2):193-194. Epub 2017 Jul 21 doi: 10.1080/00015385.2017.1351252. PMID: 28730916

See all (138)

Therapy

Left main coronary artery disease: pathophysiology, diagnosis, and treatment.

Collet C, Capodanno D, Onuma Y, Banning A, Stone GW, Taggart DP, Sabik J, Serruys PW
Nat Rev Cardiol 2018 Jun;15(6):321-331. doi: 10.1038/s41569-018-0001-4. PMID: 29599504

Percutaneous coronary intervention versus coronary artery bypass grafting: where are we after NOBLE and EXCEL?

Fortier JH, Shaw RE, Glineur D, Grau JB
Curr Opin Cardiol 2017 Nov;32(6):699-706. doi: 10.1097/HCO.0000000000000450. PMID: 28786862

Update on percutaneous intervention for left main coronary artery stenosis.

Lee PH, Ahn JM, Park SJ
Expert Rev Cardiovasc Ther 2015;13(8):933-43. Epub 2015 Jul 9 doi: 10.1586/14779072.2015.1065730. PMID: 26159652

Dynamic left main coronary artery stenosis caused by an aortic aneurysm after aortic valve replacement.

Hagenah G, Herzum M, Grimm W
Heart 2007 Apr;93(4):518. doi: 10.1136/hrt.2006.091025. PMID: 17401071 Free PMC Article

Prediction of significant left main coronary artery stenosis by the 12-lead electrocardiogram in patients with rest angina pectoris and the withholding of clopidogrel therapy.

Gaitonde RS, Sharma N, Ali-Hasan S, Miller JM, Jayachandran JV, Kalaria VG
Am J Cardiol 2003 Oct 1;92(7):846-8. doi: 10.1016/s0002-9149(03)00898-1. PMID: 14516891

See all (145)

Prognosis

Assessment of left main coronary artery disease: a comparison between invasive and noninvasive.

Left main coronary artery disease: pathophysiology, diagnosis, and treatment.

Collet C, Capodanno D, Onuma Y, Banning A, Stone GW, Taggart DP, Sabik J, Serruys PW
Nat Rev Cardiol 2018 Jun;15(6):321-331. doi: 10.1038/s41569-018-0001-4. PMID: 29599504

Classical electrocardiographic clues for left main coronary artery disease.

Sen F, Ozeke O, Kirbas O, Burak C, Kafes H, Tekin Tak B, Ozdamar U, Ocak K, Topaloglu S, Aras D
Indian Heart J 2016 Sep;68 Suppl 2(Suppl 2):S226-S227. Epub 2016 Apr 3 doi: 10.1016/j.ihj.2016.03.025. PMID: 27751297 Free PMC Article

Critical left main coronary artery stenosis identified by colour Doppler screening during pre-exercise stress echocardiogram.

Tait J, Ashton T
Can J Cardiol 2011 May-Jun;27(3):390.e13-4. doi: 10.1016/j.cjca.2010.12.055. PMID: 21601777

Left main coronary artery stenosis: clinical spectrum, pathophysiology, and management.

Conti CR, Selby JH, Christie LG, Pepine CJ, Curry RC Jr, Nichols WW, Conetta DG, Feldman RL, Mehta J, Alexander JA
Prog Cardiovasc Dis 1979 Sep-Oct;22(2):73-106. doi: 10.1016/0033-0620(79)90016-1. PMID: 384459

See all (187)

Clinical prediction guides

Left main coronary artery disease: pathophysiology, diagnosis, and treatment.

Collet C, Capodanno D, Onuma Y, Banning A, Stone GW, Taggart DP, Sabik J, Serruys PW
Nat Rev Cardiol 2018 Jun;15(6):321-331. doi: 10.1038/s41569-018-0001-4. PMID: 29599504

Classical electrocardiographic clues for left main coronary artery disease.

Increased late mortality with percutaneous stenting for unprotected left main coronary artery stenosis relative to coronary artery bypass grafting: a meta-analysis of observational studies.

Takagi H, Matsui M, Umemoto T
J Thorac Cardiovasc Surg 2010 May;139(5):1351-3. doi: 10.1016/j.jtcvs.2010.01.024. PMID: 20412967

Prediction of significant left main coronary artery stenosis by the 12-lead electrocardiogram in patients with rest angina pectoris and the withholding of clopidogrel therapy.

Gaitonde RS, Sharma N, Ali-Hasan S, Miller JM, Jayachandran JV, Kalaria VG
Am J Cardiol 2003 Oct 1;92(7):846-8. doi: 10.1016/s0002-9149(03)00898-1. PMID: 14516891

Angina in the elderly.

Duprez DA
Eur Heart J 1996 Dec;17 Suppl G:8-13. doi: 10.1093/eurheartj/17.suppl_g.8. PMID: 8960449

See all (126)

Recent systematic reviews

Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention of Unprotected Left Main Coronary Artery Stenosis: A Systematic Review and Meta-Analysis.

Bajaj A, Pancholy S, Sothwal A, Nawaz Y, Boruah P
Cardiovasc Revasc Med 2019 Sep;20(9):790-798. Epub 2018 Nov 3 doi: 10.1016/j.carrev.2018.10.025. PMID: 30442537

Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis.

Giacoppo D, Colleran R, Cassese S, Frangieh AH, Wiebe J, Joner M, Schunkert H, Kastrati A, Byrne RA
JAMA Cardiol 2017 Oct 1;2(10):1079-1088. doi: 10.1001/jamacardio.2017.2895. PMID: 28903139 Free PMC Article

Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis.

Zhang XL, Zhu QQ, Yang JJ, Chen YH, Li Y, Zhu SH, Xie J, Wang L, Kang LN, Xu B
BMC Med 2017 Apr 21;15(1):84. doi: 10.1186/s12916-017-0853-1. PMID: 28427392 Free PMC Article

Left main coronary artery stenosis: a meta-analysis of drug-eluting stents versus coronary artery bypass grafting.

Athappan G, Patvardhan E, Tuzcu ME, Ellis S, Whitlow P, Kapadia SR
JACC Cardiovasc Interv 2013 Dec;6(12):1219-30. doi: 10.1016/j.jcin.2013.07.008. PMID: 24355112

Meta-analysis and systematic review of the long-term predictive value of assessment of coronary atherosclerosis by contrast-enhanced coronary computed tomography angiography.

Bamberg F, Sommer WH, Hoffmann V, Achenbach S, Nikolaou K, Conen D, Reiser MF, Hoffmann U, Becker CR
J Am Coll Cardiol 2011 Jun 14;57(24):2426-36. doi: 10.1016/j.jacc.2010.12.043. PMID: 21658564

See all (5)

MedGen

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Left Main Coronary Artery Stenosis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity