U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Collapsing Glomerulopathy

MedGen UID:
412719
•Concept ID:
C2749515
•
Disease or Syndrome
Synonym: Collapsing glomerulopathy

Definition

Segmental or global glomerulopathy with tuft wrinkling, collapse and contraction without increased matrix or cells, but with adjacent podocyte hypertrophy and hyperplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCollapsing Glomerulopathy

Professional guidelines

PubMed

Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population.
Neves PD, Watanabe A, Watanabe EH, Narcizo AM, Nunes K, Lerario AM, Ferreira FM, Cavalcante LB, Wongboonsin J, Malheiros DM, Jorge LB, Sampson MG, Noronha IL, Onuchic LF
Kidney Int 2024 Mar;105(3):593-607. Epub 2023 Dec 22 doi: 10.1016/j.kint.2023.11.028. PMID: 38143038
Treatment potential in APOL1-associated nephropathy.
Friedman DJ, Ma L, Freedman BI
Curr Opin Nephrol Hypertens 2022 Sep 1;31(5):442-448. Epub 2022 Jul 11 doi: 10.1097/MNH.0000000000000816. [Epub ahead of print] PMID: 35894278
CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases.
Soos TJ, Meijer L, Nelson PJ
Drug News Perspect 2006 Jul-Aug;19(6):325-8. doi: 10.1358/dnp.2006.19.6.985939. PMID: 16971968

Recent clinical studies

Etiology

Collapsing Glomerulopathy.
Koirala A, Akilesh S, Jefferson JA
Adv Kidney Dis Health 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008. PMID: 39084754Free PMC Article
COVID-19 Survival and its impact on chronic kidney disease.
Long JD, Strohbehn I, Sawtell R, Bhattacharyya R, Sise ME
Transl Res 2022 Mar;241:70-82. Epub 2021 Nov 10 doi: 10.1016/j.trsl.2021.11.003. PMID: 34774843Free PMC Article
Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.
Hassler L, Reyes F, Sparks MA, Welling P, Batlle D
Clin J Am Soc Nephrol 2021 Nov;16(11):1755-1765. Epub 2021 Jun 14 doi: 10.2215/CJN.04560421. PMID: 34127485Free PMC Article
COVID-19-associated collapsing glomerulopathy: a report of two cases and literature review.
Izzedine H, Brocheriou I, Arzouk N, Seilhean D, Couvert P, Cluzel P, Pha M, Le Monnier O, Varnous S, Andreelli F, Amoura Z, Mathian A
Intern Med J 2020 Dec;50(12):1551-1558. doi: 10.1111/imj.15041. PMID: 33354883
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809

Diagnosis

Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era.
Papalia G, Barbuto S, Campus A, Vischini G
J Nephrol 2023 Jan;36(1):225-228. Epub 2022 Jun 6 doi: 10.1007/s40620-022-01351-8. PMID: 35666373Free PMC Article
Type I interferon-related kidney disorders.
Lodi L, Mastrolia MV, Bello F, Rossi GM, Angelotti ML, Crow YJ, Romagnani P, Vaglio A
Kidney Int 2022 Jun;101(6):1142-1159. Epub 2022 Mar 24 doi: 10.1016/j.kint.2022.02.031. PMID: 35339535
Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.
Hassler L, Reyes F, Sparks MA, Welling P, Batlle D
Clin J Am Soc Nephrol 2021 Nov;16(11):1755-1765. Epub 2021 Jun 14 doi: 10.2215/CJN.04560421. PMID: 34127485Free PMC Article
COVID-19-associated collapsing glomerulopathy: a report of two cases and literature review.
Izzedine H, Brocheriou I, Arzouk N, Seilhean D, Couvert P, Cluzel P, Pha M, Le Monnier O, Varnous S, Andreelli F, Amoura Z, Mathian A
Intern Med J 2020 Dec;50(12):1551-1558. doi: 10.1111/imj.15041. PMID: 33354883
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809

Therapy

Type I interferon-related kidney disorders.
Lodi L, Mastrolia MV, Bello F, Rossi GM, Angelotti ML, Crow YJ, Romagnani P, Vaglio A
Kidney Int 2022 Jun;101(6):1142-1159. Epub 2022 Mar 24 doi: 10.1016/j.kint.2022.02.031. PMID: 35339535
Collapsing glomerulopathy in systemic lupus erythematosus.
Abadeer K, Alsaad AA, Geiger XJ, Porter IE
BMJ Case Rep 2017 Feb 27;2017 doi: 10.1136/bcr-2016-217840. PMID: 28242801Free PMC Article
Sirolimus modulates HIVAN phenotype through inhibition of epithelial mesenchymal transition.
Yadav A, Kumar D, Salhan D, Rattanavich R, Maheshwari S, Adabala M, Ding G, Singhal PC
Exp Mol Pathol 2012 Aug;93(1):173-81. Epub 2012 May 2 doi: 10.1016/j.yexmp.2012.04.021. PMID: 22579465Free PMC Article
Monoclonal antibodies for podocytopathies: rationale and clinical responses.
Marasà M, Kopp JB
Nat Rev Nephrol 2009 Jun;5(6):337-48. doi: 10.1038/nrneph.2009.70. PMID: 19474828
CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases.
Soos TJ, Meijer L, Nelson PJ
Drug News Perspect 2006 Jul-Aug;19(6):325-8. doi: 10.1358/dnp.2006.19.6.985939. PMID: 16971968

Prognosis

Collapsing Glomerulopathy.
Koirala A, Akilesh S, Jefferson JA
Adv Kidney Dis Health 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008. PMID: 39084754Free PMC Article
Double glomerulopathies or two-faced janus? A challenging case in the COVID-19 era.
Papalia G, Barbuto S, Campus A, Vischini G
J Nephrol 2023 Jan;36(1):225-228. Epub 2022 Jun 6 doi: 10.1007/s40620-022-01351-8. PMID: 35666373Free PMC Article
Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.
Hassler L, Reyes F, Sparks MA, Welling P, Batlle D
Clin J Am Soc Nephrol 2021 Nov;16(11):1755-1765. Epub 2021 Jun 14 doi: 10.2215/CJN.04560421. PMID: 34127485Free PMC Article
Collapsing glomerulopathy: update.
Morales E, Alonso M, Gutiérrez E
Med Clin (Barc) 2019 May 3;152(9):361-367. Epub 2018 Dec 13 doi: 10.1016/j.medcli.2018.10.021. PMID: 30554809
Collapsing glomerulopathy.
Schwimmer JA, Markowitz GS, Valeri A, Appel GB
Semin Nephrol 2003 Mar;23(2):209-18. doi: 10.1053/snep.2003.50019. PMID: 12704581

Clinical prediction guides

Type I interferon-related kidney disorders.
Lodi L, Mastrolia MV, Bello F, Rossi GM, Angelotti ML, Crow YJ, Romagnani P, Vaglio A
Kidney Int 2022 Jun;101(6):1142-1159. Epub 2022 Mar 24 doi: 10.1016/j.kint.2022.02.031. PMID: 35339535
Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.
Hassler L, Reyes F, Sparks MA, Welling P, Batlle D
Clin J Am Soc Nephrol 2021 Nov;16(11):1755-1765. Epub 2021 Jun 14 doi: 10.2215/CJN.04560421. PMID: 34127485Free PMC Article
Malaria, Collapsing Glomerulopathy, and Focal and Segmental Glomerulosclerosis.
Amoura A, Moktefi A, Halfon M, Karras A, Rafat C, Gibier JB, Gleeson PJ, Servais A, Argy N, Maillé P, Belenfant X, Gueutin V, Delpierre A, Tricot L, El Karoui K, Jourde-Chiche N, Houze S, Sahali D, Audard V
Clin J Am Soc Nephrol 2020 Jul 1;15(7):964-972. Epub 2020 May 22 doi: 10.2215/CJN.00590120. PMID: 32444394Free PMC Article
The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease.
Li SY, Susztak K
Semin Nephrol 2018 Mar;38(2):121-126. doi: 10.1016/j.semnephrol.2018.01.003. PMID: 29602395Free PMC Article
Clofarabine-induced kidney toxicity.
Jhaveri KD, Chidella S, Allen SL, Fishbane S
J Oncol Pharm Pract 2014 Aug;20(4):305-8. Epub 2013 Sep 29 doi: 10.1177/1078155213504976. PMID: 24081220

Recent systematic reviews

Renal manifestations in adult-onset Still's disease: a systematic review.
Arya PVA, Marnet E, Rondla M, Tan JW, Unnikrishnan D, Buller G
Rheumatol Int 2024 Jul;44(7):1209-1218. Epub 2024 Apr 16 doi: 10.1007/s00296-024-05578-5. PMID: 38625385
Renal Histopathological Changes in Coronavirus Disease 2019 Patients: A Systematic Review and Meta-analysis of Individual Patient Data.
Vishwajeet V, Krishna H, Ghatak S, Elhence PA, Ambwani S, Varthya SB
Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1523-1544. doi: 10.4103/1319-2442.352410. PMID: 35946265
Collapsing glomerulopathy in collagen vascular-like disease.
Nasr R, Johns C, Gertner E
Lupus 2014;23(1):75-80. Epub 2013 Nov 27 doi: 10.1177/0961203313513509. PMID: 24285096

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...