Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Abnormal renal glomerulus morphology

MedGen UID:: 871392
•Concept ID:: C4025889
•: Anatomical Abnormality

Synonyms:	Abnormality of renal glomerulus morphology; Morphologic abnormality of the renal glomerulus

HPO:	HP:0000095

Definition

A structural anomaly of the glomerulus. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal renal glomerulus morphology

Abnormality of the urinary system
- Abnormality of the upper urinary tract
  - Abnormality of the kidney
    - Abnormal renal morphology
      - Abnormal nephron morphology
        Abnormal renal corpuscle morphology
        Abnormal renal glomerulus morphology
        Abnormal glomerular basement membrane morphology
        Abnormal glomerular basement membrane texture
        Glomerular basement membranes powdery deposit
        Diminished glomerular basement membrane collagen IV alpha 3 chain staining
        Diminished glomerular basement membrane collagen IV alpha 4 chain staining
        Diminished glomerular basement membrane collagen IV alpha 5 chain staining
        Glomerular basement membrane amyloid spicule
        Glomerular basement membrane disruption
        Glomerular basement membrane electron dense deposits
        Subendothelial glomerular basement membrane electron dense deposits
        Subepithelial glomerular basement membrane electron dense deposits
        Glomerular basement membrane lamellation
        Glomerular basement membrane lucencies
        Glomerular basement membrane spikes
        Glomerular basement membrane wrinkling
        Glomerular subendothelial widening
        Glomerular synechial adhesion
        Thickened glomerular basement membrane
        Thickened glomerular basement membranes with electron dense deposits
        Thickened glomerular basement membranes with no electron dense deposits
        Thin glomerular basement membrane
        Abnormal glomerular capillary morphology
        Abnormal glomerular capillary lumen morphology
        Deflation of the glomerular tuft
        Glomerular capillary collapse
        Glomerular capillary congestion
        Glomerular capillary microaneurysm
        Glomerular fibrin thrombus
        Glomerular hyaline pseudothrombus
        Glomerular karyhorrhectic debris
        Glomerular lipoprotein thrombus
        Abnormal glomerular endothelial cell morphology
        Glomerular endothelial tubuloreticular inclusion
        Glomerular endotheliosis
        Loss of glomerular endothelial cell fenestration
        Glomerular capillary wall duplication with cellular interposition
        Glomerular capillary wall duplication without cellular interposition
        Glomerular endocapillary hypercellularity
        Glomerular endocapillary leukocyte hypercellularity
        Glomerular fibrinoid necrosis
        Thickening of glomerular capillary wall
        Abnormal glomerular mesangium morphology
        Abnormal glomerular mesangial cellularity
        Mesangial cell loss
        Mesangial hypercellularity
        Abnormal glomerular mesangial matrix morphology
        Global mesangial sclerosis
        Mesangial matrix expansion
        Mesangiolysis
        Nodular mesangiosclerosis
        Diffuse mesangial sclerosis
        Mesangial fibril deposition
        Mesangial amyloid deposition
        Mesangial fibrillary deposits
        Mesangial immunotactoid deposits
        Mesangial microfibril deposition
        Mesangial hyaline deposition
        Mesangial Immune complex deposition
        Paramesangial deposits
        Glomerular deposits
        Glomerular C3 deposition
        Glomerular capillary wire loop deposits
        Glomerular fibronectin deposits
        Glomerular subendothelial electron-dense deposits
        Glomerular subepithelial deposits
        Fibrillar glomerular subepithelial deposits
        Glomerular hyaline subepithelial deposits
        Glomerular subepithelial immune-complex deposits
        IgA deposition in the glomerulus
        Glomerular extracapillary hypercellularity
        Glomerular immune-complex deposition
        Glomerular PLA2R immune-complex deposition
        Glomerular sclerosis
        Focal segmental glomerulosclerosis
        Chronic rejection of renal transplant
        Focal Segmental Glomerulosclerosis Cellular Variant
        Focal Segmental Glomerulosclerosis Collapsing Variant
        Focal Segmental Glomerulosclerosis Perihilar Variant
        Focal Segmental Glomerulosclerosis Tip Lesion Variant
        Focal Segmental Glomerulosclerosis, Not Otherwise Specified
        HIV-associated nephropathy
        Inherited focal segmental glomerulosclerosis
        Obesity Related Glomerulopathy
        Primary focal segmental glomerulosclerosis
        Secondary Focal Segmental Glomerulosclerosis
        Global glomerulosclerosis
        Glomerular obsolescence
        Segmental glomerulosclerosis
        Perihilar segmental glomerulosclerosis
        Segmental glomerulosclerosis away from the vascular and tubular poles
        Tip variant segmental glomerulosclerosis
        Glomerulomegaly
        Glomerulopathy
        Collapsing Glomerulopathy
        Glomerulocystic Disease
        Idiopathic Membranous Glomerulopathy
        Membranous Nephropathy - Secondary
        Primary Collapsing Glomerulopathy
        Secondary Collapsing Glomerulopathy
        Tip Lesion Glomerulopathy
        Multiple glomerular cysts
        Obliterative abnormality of the renal glomerulus
        Glomerular hyalinosis
        Glomerular hyalinosis at the tubular pole
        Glomerular hyalinosis away from the vascular and tubular poles
        Perihilar glomerular hyalinosis
        Renal juxtaglomerular cell hypertrophy/hyperplasia

Conditions with this feature

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome

MedGen UID:: 1373459
•Concept ID:: C4317151
•: Disease or Syndrome

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome is an autosomal dominant disorder characterized by these 4 features, which begin in early childhood and are progressive (summary by Moalem et al., 2015).

See: Condition Record

Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome

Professional guidelines

PubMed

Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease.

Petrazzuolo A, Sabiu G, Assi E, Maestroni A, Pastore I, Lunati ME, Montefusco L, Loretelli C, Rossi G, Ben Nasr M, Usuelli V, Xie Y, Balasubramanian HB, Zocchi M, El Essawy B, Yang J, D'Addio F, Fiorina P
Pharmacol Res 2023 Apr;190:106710. Epub 2023 Mar 4 doi: 10.1016/j.phrs.2023.106710. PMID: 36871895

Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.

Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.

Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nat Genet 2017 Oct;49(10):1529-1538. Epub 2017 Aug 14 doi: 10.1038/ng.3933. PMID: 28805828 Free PMC Article

See all (21)

Recent clinical studies

Etiology

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

De novo glomerular diseases after renal transplantation.

Ponticelli C, Moroni G, Glassock RJ
Clin J Am Soc Nephrol 2014 Aug 7;9(8):1479-87. Epub 2014 Apr 3 doi: 10.2215/CJN.12571213. PMID: 24700797 Free PMC Article

Kidney disease in nail-patella syndrome.

Lemley KV
Pediatr Nephrol 2009 Dec;24(12):2345-54. Epub 2008 Jun 6 doi: 10.1007/s00467-008-0836-8. PMID: 18535845 Free PMC Article

Thin basement membrane nephropathy.

Tryggvason K, Patrakka J
J Am Soc Nephrol 2006 Mar;17(3):813-22. Epub 2006 Feb 8 doi: 10.1681/ASN.2005070737. PMID: 16467446

Pulmonary renal syndromes. II. Etiology and pathogenesis.

Rankin JA, Matthay RA
Yale J Biol Med 1982 Jan-Feb;55(1):11-26. PMID: 6810558 Free PMC Article

See all (379)

Diagnosis

Membranoproliferative glomerulonephritis: no longer the same disease and may need very different treatment.

Noris M, Daina E, Remuzzi G
Nephrol Dial Transplant 2023 Feb 13;38(2):283-290. doi: 10.1093/ndt/gfab281. PMID: 34596686

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Collagenofibrotic glomerulopathy.

Patel S, Cimbaluk D
Kidney Int 2016 Jun;89(6):1406. doi: 10.1016/j.kint.2015.12.056. PMID: 27181787

Alport's syndrome, Goodpasture's syndrome, and type IV collagen.

Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG
N Engl J Med 2003 Jun 19;348(25):2543-56. doi: 10.1056/NEJMra022296. PMID: 12815141

Glomerular disease.

Kashtan CE
Semin Nephrol 1999 Jul;19(4):353-63. PMID: 10435673

See all (486)

Therapy

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.

DeFronzo RA, Reeves WB, Awad AS
Nat Rev Nephrol 2021 May;17(5):319-334. Epub 2021 Feb 5 doi: 10.1038/s41581-021-00393-8. PMID: 33547417

C3 glomerulopathy and current dilemmas.

Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657 Free PMC Article

De novo glomerular diseases after renal transplantation.

Ponticelli C, Moroni G, Glassock RJ
Clin J Am Soc Nephrol 2014 Aug 7;9(8):1479-87. Epub 2014 Apr 3 doi: 10.2215/CJN.12571213. PMID: 24700797 Free PMC Article

Glomerular disease.

Rosen S, Galvanek E, Levy M, Habib R
Hum Pathol 1981 Nov;12(11):964-77. doi: 10.1016/s0046-8177(81)80253-5. PMID: 6459285

See all (215)

Prognosis

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Podocytopathies.

Kopp JB, Anders HJ, Susztak K, Podestà MA, Remuzzi G, Hildebrandt F, Romagnani P
Nat Rev Dis Primers 2020 Aug 13;6(1):68. doi: 10.1038/s41572-020-0196-7. PMID: 32792490 Free PMC Article

Nail-patella syndrome.

Witzgall R
Pflugers Arch 2017 Aug;469(7-8):927-936. Epub 2017 Jul 5 doi: 10.1007/s00424-017-2013-z. PMID: 28681095

C3 glomerulopathy and current dilemmas.

Ito N, Ohashi R, Nagata M
Clin Exp Nephrol 2017 Aug;21(4):541-551. Epub 2016 Nov 23 doi: 10.1007/s10157-016-1358-5. PMID: 27878657 Free PMC Article

Pathophysiology of proteinuria.

D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

See all (303)

Clinical prediction guides

The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease.

Clair G, Soloyan H, Cravedi P, Angeletti A, Salem F, Al-Rabadi L, De Filippo RE, Da Sacco S, Lemley KV, Sedrakyan S, Perin L
JCI Insight 2024 Mar 22;9(6) doi: 10.1172/jci.insight.165515. PMID: 38516889 Free PMC Article

IgA Nephropathy: Core Curriculum 2021.

Pattrapornpisut P, Avila-Casado C, Reich HN
Am J Kidney Dis 2021 Sep;78(3):429-441. Epub 2021 Jul 9 doi: 10.1053/j.ajkd.2021.01.024. PMID: 34247883

Immunopathogenesis of idiopathic nephrotic syndrome with relapse.

Sahali D, Sendeyo K, Mangier M, Audard V, Zhang SY, Lang P, Ollero M, Pawlak A
Semin Immunopathol 2014 Jul;36(4):421-9. Epub 2014 Jan 9 doi: 10.1007/s00281-013-0415-3. PMID: 24402710 Free PMC Article

Basement membranes and human disease.

Van Agtmael T, Bruckner-Tuderman L
Cell Tissue Res 2010 Jan;339(1):167-88. Epub 2009 Sep 15 doi: 10.1007/s00441-009-0866-y. PMID: 19756754

Pathophysiology of proteinuria.

D'Amico G, Bazzi C
Kidney Int 2003 Mar;63(3):809-25. doi: 10.1046/j.1523-1755.2003.00840.x. PMID: 12631062

See all (414)

MedGen

National Center for Biotechnology Information

Send to:

Abnormal renal glomerulus morphology

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity