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Herpes zoster

MedGen UID:
42437
Concept ID:
C0019360
Disease or Syndrome
Synonym: Shingles
SNOMED CT: Zoster (4740000); Herpes zoster infection (4740000); Herpes zoster (4740000); Shingles (4740000); Zona (4740000)
 
Monarch Initiative: MONDO:0005609

Definition

A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient''s initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Patil A, Goldust M, Wollina U
Viruses 2022 Jan 19;14(2) doi: 10.3390/v14020192. PMID: 35215786Free PMC Article
Cushing K, Higgins PDR
JAMA 2021 Jan 5;325(1):69-80. doi: 10.1001/jama.2020.18936. PMID: 33399844Free PMC Article
Saguil A, Kane S, Mercado M, Lauters R
Am Fam Physician 2017 Nov 15;96(10):656-663. PMID: 29431387

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Harbecke R, Cohen JI, Oxman MN
J Infect Dis 2021 Sep 30;224(12 Suppl 2):S429-S442. doi: 10.1093/infdis/jiab387. PMID: 34590136Free PMC Article
Cohen EJ, Jeng BH
Cornea 2021 Aug 1;40(8):943-949. doi: 10.1097/ICO.0000000000002754. PMID: 34029242Free PMC Article
Le P, Rothberg M
BMJ 2019 Jan 10;364:k5095. doi: 10.1136/bmj.k5095. PMID: 30630827
Koshy E, Mengting L, Kumar H, Jianbo W
Indian J Dermatol Venereol Leprol 2018 May-Jun;84(3):251-262. doi: 10.4103/ijdvl.IJDVL_1021_16. PMID: 29516900
Saguil A, Kane S, Mercado M, Lauters R
Am Fam Physician 2017 Nov 15;96(10):656-663. PMID: 29431387

Diagnosis

Narainswami N
S Afr Med J 2023 Aug 3;113(8):28-29. doi: 10.7196/SAMJ.2023.v113i8.649. PMID: 37882117
Hirade T, Koike D, Matama C, Yamada K, Kato F
Pediatr Int 2022 Jan;64(1):e15111. doi: 10.1111/ped.15111. PMID: 35831585
Zhang Y, Kong Y, Liu ZH
QJM 2022 Jun 7;115(6):402. doi: 10.1093/qjmed/hcac109. PMID: 35482516
Le P, Rothberg M
BMJ 2019 Jan 10;364:k5095. doi: 10.1136/bmj.k5095. PMID: 30630827
Schmader K
Ann Intern Med 2018 Aug 7;169(3):ITC19-ITC31. doi: 10.7326/AITC201808070. PMID: 30083718

Therapy

Zerbo O, Bartlett J, Fireman B, Lewis N, Goddard K, Dooling K, Duffy J, Glanz J, Naleway A, Donahue JG, Klein NP
Ann Intern Med 2024 Feb;177(2):189-195. Epub 2024 Jan 9 doi: 10.7326/M23-2023. PMID: 38190712Free PMC Article
D'Haens G, Dubinsky M, Kobayashi T, Irving PM, Howaldt S, Pokrotnieks J, Krueger K, Laskowski J, Li X, Lissoos T, Milata J, Morris N, Arora V, Milch C, Sandborn W, Sands BE; LUCENT Study Group
N Engl J Med 2023 Jun 29;388(26):2444-2455. doi: 10.1056/NEJMoa2207940. PMID: 37379135
Loftus EV Jr, Panés J, Lacerda AP, Peyrin-Biroulet L, D'Haens G, Panaccione R, Reinisch W, Louis E, Chen M, Nakase H, Begun J, Boland BS, Phillips C, Mohamed MF, Liu J, Geng Z, Feng T, Dubcenco E, Colombel JF
N Engl J Med 2023 May 25;388(21):1966-1980. doi: 10.1056/NEJMoa2212728. PMID: 37224198
Bolton L
Wounds 2018 May;30(5):144-146. PMID: 29847305
Warren-Gash C, Forbes H, Breuer J
Expert Rev Vaccines 2017 Dec;16(12):1191-1201. Epub 2017 Oct 30 doi: 10.1080/14760584.2017.1394843. PMID: 29047317Free PMC Article

Prognosis

Asada H
J Dermatol 2023 Mar;50(3):305-310. Epub 2022 Dec 20 doi: 10.1111/1346-8138.16666. PMID: 36539935
Gershon AA, Gershon MD, Shapiro ED
J Infect Dis 2021 Sep 30;224(12 Suppl 2):S387-S397. doi: 10.1093/infdis/jiaa573. PMID: 34590140Free PMC Article
Cohen EJ, Jeng BH
Cornea 2021 Aug 1;40(8):943-949. doi: 10.1097/ICO.0000000000002754. PMID: 34029242Free PMC Article
Varela FH, Pinto LA, Scotta MC
Hum Vaccin Immunother 2019;15(3):645-657. Epub 2018 Dec 10 doi: 10.1080/21645515.2018.1546525. PMID: 30427766Free PMC Article
Kawai K, Gebremeskel BG, Acosta CJ
BMJ Open 2014 Jun 10;4(6):e004833. doi: 10.1136/bmjopen-2014-004833. PMID: 24916088Free PMC Article

Clinical prediction guides

Nakano H, Fujiwara T, Tsujimoto Y, Morishima N, Kasahara T, Ameya M, Tachibana K, Sanada S, Toufukuji S, Hato N
Auris Nasus Larynx 2024 Feb;51(1):154-160. Epub 2023 May 4 doi: 10.1016/j.anl.2023.04.007. PMID: 37149416
Zhang Z, Liu X, Suo L, Zhao D, Pan J, Lu L
Hum Vaccin Immunother 2023 Aug 1;19(2):2228169. Epub 2023 Jul 9 doi: 10.1080/21645515.2023.2228169. PMID: 37424092Free PMC Article
Loftus EV Jr, Panés J, Lacerda AP, Peyrin-Biroulet L, D'Haens G, Panaccione R, Reinisch W, Louis E, Chen M, Nakase H, Begun J, Boland BS, Phillips C, Mohamed MF, Liu J, Geng Z, Feng T, Dubcenco E, Colombel JF
N Engl J Med 2023 May 25;388(21):1966-1980. doi: 10.1056/NEJMoa2212728. PMID: 37224198
Giannelos N, Ng C, Curran D
Hum Vaccin Immunother 2023 Dec 31;19(1):2168952. Epub 2023 Mar 14 doi: 10.1080/21645515.2023.2168952. PMID: 36916240Free PMC Article
Fleischmann R, Pangan AL, Song IH, Mysler E, Bessette L, Peterfy C, Durez P, Ostor AJ, Li Y, Zhou Y, Othman AA, Genovese MC
Arthritis Rheumatol 2019 Nov;71(11):1788-1800. Epub 2019 Aug 28 doi: 10.1002/art.41032. PMID: 31287230

Recent systematic reviews

Nakano H, Fujiwara T, Tsujimoto Y, Morishima N, Kasahara T, Ameya M, Tachibana K, Sanada S, Toufukuji S, Hato N
Auris Nasus Larynx 2024 Feb;51(1):154-160. Epub 2023 May 4 doi: 10.1016/j.anl.2023.04.007. PMID: 37149416
Din S, Selinger CP, Black CJ, Ford AC
Aliment Pharmacol Ther 2023 Mar;57(6):666-675. Epub 2022 Dec 31 doi: 10.1111/apt.17379. PMID: 36585944
Lin CS, Lin YC, Lao HC, Chen CC
Pain Physician 2019 May;22(3):209-228. PMID: 31151330
Kawai K, Yawn BP
Mayo Clin Proc 2017 Dec;92(12):1806-1821. doi: 10.1016/j.mayocp.2017.10.009. PMID: 29202939
Kawai K, Gebremeskel BG, Acosta CJ
BMJ Open 2014 Jun 10;4(6):e004833. doi: 10.1136/bmjopen-2014-004833. PMID: 24916088Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

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