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AIDS-Related Lymphoma

MedGen UID:
43099
•Concept ID:
C0085090
•
Neoplastic Process
Synonyms: AIDS Associated Lymphoma; AIDS Related Lymphoma; AIDS-Associated Lymphoma; AIDS-Associated Lymphomas; AIDS-Related Lymphomas; HIV Related Lymphoma; HIV-Related Lymphoma; HIV-Related Lymphomas; Lymphoma, AIDS Associated; Lymphoma, AIDS Related; Lymphoma, AIDS-Associated; Lymphoma, AIDS-Related; Lymphoma, HIV Related; Lymphoma, HIV-Related; Lymphomas, AIDS-Associated; Lymphomas, AIDS-Related; Lymphomas, HIV-Related

Definition

An aggressive lymphoma that develops in HIV-positive patients. There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic. These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt, diffuse large B-cell, and Hodgkin lymphomas. The prognosis is closely related to the severity of immunodeficiency. [from NCI]

Professional guidelines

PubMed

Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Management of AIDS-related lymphoma.
Levine AM
Curr Opin Oncol 2008 Sep;20(5):522-8. doi: 10.1097/CCO.0b013e3283094ec7. PMID: 19106654
Actual status of AIDS-related lymphoma management in Japan.
Nagai H, Iwasaki N, Odawara T, Okada S
Int J Hematol 2008 May;87(4):442-443. doi: 10.1007/s12185-008-0073-8. PMID: 18389175

Recent clinical studies

Etiology

Hematologic cancers in individuals infected by HIV.
Carbone A, Vaccher E, Gloghini A
Blood 2022 Feb 17;139(7):995-1012. doi: 10.1182/blood.2020005469. PMID: 34469512
Optimizing treatment of HIV-associated lymphoma.
Noy A
Blood 2019 Oct 24;134(17):1385-1394. doi: 10.1182/blood-2018-01-791400. PMID: 30992269Free PMC Article
HIV-Associated Malignancies.
Hübel K
Oncol Res Treat 2017;40(3):80-81. Epub 2017 Feb 20 doi: 10.1159/000456716. PMID: 28273669
HIV-associated lymphoma.
Kaplan LD
Best Pract Res Clin Haematol 2012 Mar;25(1):101-17. Epub 2012 Feb 22 doi: 10.1016/j.beha.2012.01.001. PMID: 22409827
AIDS-related malignancies.
Scadden DT
Annu Rev Med 2003;54:285-303. Epub 2001 Dec 3 doi: 10.1146/annurev.med.54.101601.152143. PMID: 12525676

Diagnosis

AIDS-Related Burkitt Lymphoma Presenting Multiple Nodules in the Pancreas.
Kohashi S, Sakai A, Kodama Y
Clin Gastroenterol Hepatol 2022 May;20(5):e920. Epub 2021 Jul 14 doi: 10.1016/j.cgh.2021.07.017. PMID: 34273565
HIV-Associated Malignancies.
Hübel K
Oncol Res Treat 2017;40(3):80-81. Epub 2017 Feb 20 doi: 10.1159/000456716. PMID: 28273669
Non-Hodgkin's lymphomas.
Theodossiou C, Schwarzenberger P
Clin Obstet Gynecol 2002 Sep;45(3):820-9. doi: 10.1097/00003081-200209000-00029. PMID: 12370624
Burkitt's lymphoma.
Shapira J, Peylan-Ramu N
Oral Oncol 1998 Jan;34(1):15-23. doi: 10.1016/s1368-8375(97)00041-9. PMID: 9659515
Infective neuropathies.
Said G
Curr Opin Neurol 1994 Oct;7(5):398-401. doi: 10.1097/00019052-199410000-00006. PMID: 7804459

Therapy

Optimizing treatment of HIV-associated lymphoma.
Noy A
Blood 2019 Oct 24;134(17):1385-1394. doi: 10.1182/blood-2018-01-791400. PMID: 30992269Free PMC Article
HIV-Associated Malignancies.
Hübel K
Oncol Res Treat 2017;40(3):80-81. Epub 2017 Feb 20 doi: 10.1159/000456716. PMID: 28273669
Immunodeficiency-related Hodgkin lymphoma and its mimics.
Said JW
Adv Anat Pathol 2007 May;14(3):189-94. doi: 10.1097/PAP.0b013e31805048fc. PMID: 17452815
AIDS-associated malignancies.
Shah MH, Porcu P, Mallery SR, Caligiuri MA
Cancer Chemother Biol Response Modif 2003;21:717-46. doi: 10.1016/s0921-4410(03)21034-6. PMID: 15338771
Non-Hodgkin's lymphomas.
Theodossiou C, Schwarzenberger P
Clin Obstet Gynecol 2002 Sep;45(3):820-9. doi: 10.1097/00003081-200209000-00029. PMID: 12370624

Prognosis

AIDS-related primary CNS lymphoma.
Karia SJ, McArdle DJT
Lancet 2017 Jun 3;389(10085):2238. Epub 2017 Apr 6 doi: 10.1016/S0140-6736(17)30056-9. PMID: 28392104
HIV-Associated Malignancies.
Hübel K
Oncol Res Treat 2017;40(3):80-81. Epub 2017 Feb 20 doi: 10.1159/000456716. PMID: 28273669
Epidemiology of brain tumors.
Davis FS
Expert Rev Anticancer Ther 2007 Dec;7(12 Suppl):S3-6. doi: 10.1586/14737140.7.12s.S3. PMID: 18076316
Non-Hodgkin's lymphomas.
Theodossiou C, Schwarzenberger P
Clin Obstet Gynecol 2002 Sep;45(3):820-9. doi: 10.1097/00003081-200209000-00029. PMID: 12370624
Neuroepidemiology of HIV infection.
Dal Pan GJ, McArthur JC
Neurol Clin 1996 May;14(2):359-82. doi: 10.1016/s0733-8619(05)70262-0. PMID: 8827177

Clinical prediction guides

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma.
Thorball CW, Oudot-Mellakh T, Ehsan N, Hammer C, Santoni FA, Niay J, Costagliola D, Goujard C, Meyer L, Wang SS, Hussain SK, Theodorou I, Cavassini M, Rauch A, Battegay M, Hoffmann M, Schmid P, Bernasconi E, Günthard HF, Mohammadi P, McLaren PJ, Rabkin CS, Besson C, Fellay J
Haematologica 2021 Aug 1;106(8):2233-2241. doi: 10.3324/haematol.2020.247023. PMID: 32675224Free PMC Article
Extended use of serum free light chain as a biomarker in lymphoproliferative disorders: a comprehensive review.
Charafeddine KM, Jabbour MN, Kadi RH, Daher RT
Am J Clin Pathol 2012 Jun;137(6):890-7. doi: 10.1309/AJCP4INKZ6LYAQXW. PMID: 22586047
The use of antiviral drugs in the prevention and treatment of Kaposi sarcoma, multicentric Castleman disease and primary effusion lymphoma.
Casper C, Wald A
Curr Top Microbiol Immunol 2007;312:289-307. doi: 10.1007/978-3-540-34344-8_11. PMID: 17089802
Epidemiologic trends in HIV-associated lymphomas.
Clarke CA, Glaser SL
Curr Opin Oncol 2001 Sep;13(5):354-9. doi: 10.1097/00001622-200109000-00007. PMID: 11555712
Endobronchial lesions in HIV-infected individuals.
Judson MA, Sahn SA
Chest 1994 May;105(5):1314-23. doi: 10.1378/chest.105.5.1314. PMID: 8181313

Recent systematic reviews

Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma.
Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
Ann Oncol 2015 May;26(5):958-966. Epub 2015 Jan 28 doi: 10.1093/annonc/mdv036. PMID: 25632071Free PMC Article
Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: a systematic review.
Cobucci RN, Lima PH, de Souza PC, Costa VV, Cornetta Mda C, Fernandes JV, Gonçalves AK
J Infect Public Health 2015 Jan-Feb;8(1):1-10. Epub 2014 Oct 5 doi: 10.1016/j.jiph.2014.08.003. PMID: 25294086
Interventions for previously untreated patients with AIDS-associated non-Hodgkin's lymphoma.
Martí-Carvajal AJ, Cardona AF, Lawrence A
Cochrane Database Syst Rev 2009 Jul 8;(3):CD005419. doi: 10.1002/14651858.CD005419.pub2. PMID: 19588373
Interventions for treating AIDS-associated Hodgkin s lymphoma in treatment-naive adults.
Martí-Carvajal AJ, Cardona AF, Rodríguez ML
Cochrane Database Syst Rev 2007 Apr 18;(2):CD006149. doi: 10.1002/14651858.CD006149.pub2. PMID: 17443616
Strategies to overcome myelotoxic therapy for the treatment of Burkitt's and AIDS-related non-Hodgkin's lymphoma.
Rochford R, Feuer G, Orem J, Banura C, Katongole-Mbidde E, Mwanda WO, Moormann A, Harrington WJ, Remick SC
East Afr Med J 2005 Sep;82(9 Suppl):S155-60. doi: 10.4314/eamj.v82i9.9388. PMID: 16619692

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