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Liposarcoma

MedGen UID:
44177
•Concept ID:
C0023827
•
Neoplastic Process
Synonym: Liposarcomas
SNOMED CT: Liposarcoma (254829001); Fibroliposarcoma (1162815008); Liposarcoma (1162815008); Malignant lipomatous tumor (1162815008); Malignant lipomatous tumor (254829001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
HPO: HP:0012034
Monarch Initiative: MONDO:0005060
Orphanet: ORPHA69078

Definition

Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiposarcoma
Follow this link to review classifications for Liposarcoma in Orphanet.

Professional guidelines

PubMed

Retroperitoneal tumors: Review of diagnosis and management.
Sassa N
Int J Urol 2020 Dec;27(12):1058-1070. Epub 2020 Sep 10 doi: 10.1111/iju.14361. PMID: 32914475
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Management of Truncal Sarcoma.
Mullinax JE, Gonzalez RJ
Surg Clin North Am 2016 Oct;96(5):1003-13. doi: 10.1016/j.suc.2016.06.005. PMID: 27542639

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Retroperitoneal Dedifferentiated Liposarcoma.
Dehner CA, Hagemann IS, Chrisinger JSA
Am J Clin Pathol 2021 Oct 13;156(5):920-925. doi: 10.1093/ajcp/aqab051. PMID: 34125170
Magnetic resonance imaging of trunk and extremity myxoid liposarcoma: diagnosis, staging, and response to treatment.
Saifuddin A, Andrei V, Rajakulasingam R, Oliveira I, Seddon B
Skeletal Radiol 2021 Oct;50(10):1963-1980. Epub 2021 Apr 1 doi: 10.1007/s00256-021-03769-w. PMID: 33792747
Current Concepts in Non-Gastrointestinal Stromal Tumor Soft Tissue Sarcomas: A Primer for Radiologists.
Baheti AD, Jagannathan JP, O'Neill A, Tirumani H, Tirumani SH
Korean J Radiol 2017 Jan-Feb;18(1):94-106. Epub 2017 Jan 5 doi: 10.3348/kjr.2017.18.1.94. PMID: 28096721Free PMC Article
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Diagnosis

Myxoid Liposarcoma: How to Stage and Follow.
Ho TP
Curr Treat Options Oncol 2023 Apr;24(4):292-299. Epub 2023 Mar 3 doi: 10.1007/s11864-023-01064-5. PMID: 36867390
Primary Orbital Dedifferentiated Liposarcoma.
Yamazaki D, Ogihara N, Horiuchi T
World Neurosurg 2020 Jul;139:604-607. Epub 2020 Apr 25 doi: 10.1016/j.wneu.2020.04.069. PMID: 32339743
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045
Liposarcomas.
Henze J, Bauer S
Hematol Oncol Clin North Am 2013 Oct;27(5):939-55. doi: 10.1016/j.hoc.2013.07.010. PMID: 24093169

Therapy

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Clinical and preclinical features of eribulin-related peripheral neuropathy.
Tarasiuk O, Cavaletti G, Meregalli C
Exp Neurol 2022 Feb;348:113925. Epub 2021 Nov 18 doi: 10.1016/j.expneurol.2021.113925. PMID: 34801586
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial.
Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D'Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR
Lancet 2016 Apr 16;387(10028):1629-37. Epub 2016 Feb 10 doi: 10.1016/S0140-6736(15)01283-0. PMID: 26874885
Novel treatment targets in sarcoma: more than just the GIST.
Shoushtari AN, Van Tine BA, Schwartz GK
Am Soc Clin Oncol Educ Book 2014:e488-95. doi: 10.14694/EdBook_AM.2014.34.e488. PMID: 24857144

Prognosis

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas.
Bonvalot S, Roland C, Raut C, Le Péchoux C, Tzanis D, Frezza AM, Gronchi A
Eur J Surg Oncol 2023 Jun;49(6):1061-1067. Epub 2022 May 16 doi: 10.1016/j.ejso.2022.05.010. PMID: 35599138
Extracellular vesicle cross-talk in the liposarcoma microenvironment.
Casadei L, Pollock RE
Cancer Lett 2020 Sep 1;487:27-33. Epub 2020 May 26 doi: 10.1016/j.canlet.2020.04.026. PMID: 32470489
Sarcomas of the kidney.
Fernández Aceñero MJ, Hernández Gómez MJ, Blanco González J, Suárez Aliaga B
Minerva Urol Nefrol 1997 Sep;49(3):145-9. PMID: 9396222
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370
Liposarcoma.
Brasfield RD, Das Gupta TK
CA Cancer J Clin 1970 Jan-Feb;20(1):3-8. PMID: 5005753

Clinical prediction guides

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Multiply recurrent retroperitoneal liposarcoma.
Bagaria SP, Gabriel E, Mann GN
J Surg Oncol 2018 Jan;117(1):62-68. Epub 2017 Dec 19 doi: 10.1002/jso.24929. PMID: 29266232
Molecular cytogenetics of pediatric adipocytic tumors.
Dadone B, Refae S, Lemarié-Delaunay C, Bianchini L, Pedeutour F
Cancer Genet 2015 Oct;208(10):469-81. Epub 2015 Jun 26 doi: 10.1016/j.cancergen.2015.06.005. PMID: 26319758
Primary orbital liposarcoma.
Torrado CS, Zaldibar NM, Velasco-Benito V, Fernández-Hermida R
J Craniofac Surg 2011 May;22(3):1139-41. doi: 10.1097/SCS.0b013e3182108fdd. PMID: 21586970
Multicentric liposarcoma.
Sato H, Minei S, Sugimoto S, Kishimoto Y, Yoshida T, Takimoto Y
Int J Urol 2004 Dec;11(12):1133-5. doi: 10.1111/j.1442-2042.2004.00958.x. PMID: 15663689

Recent systematic reviews

Molecular characteristics and systemic treatment options of liposarcoma: A systematic review.
Zhou XP, Xing JP, Sun LB, Tian SQ, Luo R, Liu WH, Song XY, Gao SH
Biomed Pharmacother 2024 Sep;178:117204. Epub 2024 Jul 26 doi: 10.1016/j.biopha.2024.117204. PMID: 39067161
Special features of sarcomas developed in patients with Lynch syndrome: A systematic review.
Poumeaud F, Valentin T, Vande Perre P, Jaffrelot M, Bonnet D, Chibon F, Chevreau C, Selves J, Guimbaud R, Fares N
Crit Rev Oncol Hematol 2023 Aug;188:104055. Epub 2023 Jun 8 doi: 10.1016/j.critrevonc.2023.104055. PMID: 37301271
Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Liposarcoma of oral cavity: Systematic review of cases reported to date and analysis of prognostic factors.
Pontes FSC, de Souza LL, Vulcão ÉNC, de Abreu MC, Menezes SN, Rezende D, Pontes HAR
Head Neck 2020 Sep;42(9):2626-2634. Epub 2020 Apr 20 doi: 10.1002/hed.26160. PMID: 32309895
Surgical management of truncal and extremities atypical lipomatous tumors/well-differentiated liposarcoma: A systematic review of the literature.
Choi KY, Jost E, Mack L, Bouchard-Fortier A
Am J Surg 2020 May;219(5):823-827. Epub 2020 Jan 28 doi: 10.1016/j.amjsurg.2020.01.046. PMID: 32029218

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Reviews

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