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Lipomatous tumor

MedGen UID:: 61646
•Concept ID:: C0206631
•: Neoplastic Process

Synonyms:	Adipose Tissue Neoplasm; Adipose Tissue Neoplasms; Neoplasm, Adipose Tissue; Neoplasms, Adipose Tissue
SNOMED CT:	Lipomatous neoplasm (115227001); Adipocytic neoplasm (115227001); Soft tissue tumor of adipose differentiation (115227001); Fatty neoplasm (254827004); Lipomatous tumor (254827004); Tumor of adipose tissue (254831005)

HPO:	HP:0012031
Monarch Initiative:	MONDO:0021354

Definition

A benign, intermediate, or malignant mesenchymal neoplasm composed of adipose (fatty) tissue. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLipomatous tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Connective and Soft Tissue Disorder
        Connective and soft tissue neoplasm
        Lipomatous tumor
        Adrenal gland myelolipoma
        Angiolipoma
        Breast Angiolipoma
        Central Nervous System Angiolipoma
        Epidural spinal canal angiolipoma
        Infiltrating angiolipoma
        Skin Angiolipoma
        Angiomyolipoma
        Epithelioid type angiomyolipoma
        Kidney Epithelioid Angiomyolipoma
        Hepatic angiomyolipoma
        Kidney angiomyolipoma
        Childhood kidney angiomyolipoma
        Benign lipomatous neoplasm
        Lipoblastoma
        Lipoblastomatosis
        Lipoma
        Axillary lipoma
        Bone Lipoma
        Breast lipoma
        Central nervous system lipoma
        Chest wall lipoma
        Chondroid lipoma
        Conventional lipoma
        Deep Lipoma
        Digestive System Lipoma
        Endobronchial lipoma
        External ear lipoma
        Fibrolipoma
        Fibromyxolipoma
        Frontal cutaneous lipoma
        Heart lipoma
        Hibernoma
        Intraosseous lipoma
        Kidney lipoma
        Lipomas of eyelids
        Mediastinal Lipoma
        Myolipoma
        Oral Cavity Lipoma
        Paratesticular lipoma
        Pleural lipoma
        Salivary Gland Lipoma
        Skin lipoma
        Spinal lipoma
        Spindle Cell/Pleomorphic Lipoma
        Tonsillar lipoma
        Vulvar Lipoma
        Multiple symmetric lipomatosis
        Diffuse lipomatosis
        Encephalocraniocutaneous lipomatosis
        HIV Lipodystrophy
        Lipomatosis of Nerve
        Mediastinal lipomatosis
        Pelvic lipomatosis
        Steroid lipomatosis
        Spindle cell liposarcoma
        Vulvar Lipoblastoma-Like Tumor
        Intermediate Lipomatous Neoplasm
        Atypical lipomatous tumor
        Atypical Lipomatous Tumor/Well Differentiated Liposarcoma of Deep Soft Tissue
        Inflammatory liposarcoma
        Sclerosing liposarcoma
        Skin Atypical Lipomatous Tumor/Well Differentiated Liposarcoma
        Superficial Atypical Lipomatous Tumor/Well Differentiated Liposarcoma
        Well-differentiated liposarcoma
        Liposarcoma
        Adult liposarcoma
        Breast liposarcoma
        Colon Liposarcoma
        Cutaneous liposarcoma
        Skin Pleomorphic Liposarcoma
        Dedifferentiated liposarcoma
        Metastatic Dedifferentiated Liposarcoma
        Recurrent Dedifferentiated Liposarcoma
        Refractory Dedifferentiated Liposarcoma
        Resectable Dedifferentiated Liposarcoma
        Unresectable Dedifferentiated Liposarcoma
        Esophagus liposarcoma
        Gastric liposarcoma
        Intracranial liposarcoma
        Tongue Liposarcoma
        Kidney liposarcoma
        Larynx liposarcoma
        Liposarcoma of bone
        Liposarcoma of the ovary
        Ovarian myxoid liposarcoma
        Localized Liposarcoma
        Mediastinum liposarcoma
        Thymoliposarcoma
        Metastatic Liposarcoma
        Advanced Liposarcoma
        Locally Advanced Liposarcoma
        Metastatic Myxoid Liposarcoma
        Mixed liposarcoma
        Myxoid liposarcoma
        Myxoid Pleomorphic Liposarcoma
        Myxoid/round cell liposarcoma
        Recurrent Myxoid Liposarcoma
        Refractory Myxoid Liposarcoma
        Unresectable Myxoid Liposarcoma
        Paratesticular Liposarcoma
        Parotid Gland Liposarcoma
        Pediatric liposarcoma
        Pleomorphic liposarcoma
        Recurrent Liposarcoma
        Refractory Liposarcoma
        Resectable Liposarcoma
        Scrotal Liposarcoma
        Unresectable Liposarcoma
        Vulvar liposarcoma
        Multiple lipomas
        Testicular lipomatosis
        Skin Lipomatous Neoplasm

Professional guidelines

PubMed

Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.

Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512

Differential diagnosis of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma by cytological analysis.

Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861 Free PMC Article

The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.

Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

See all (11)

Recent clinical studies

Etiology

The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.

Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases.

Sebire NJ, Fowler D, Ramsay AD
Fetal Pediatr Pathol 2004 Sep-Dec;23(5-6):295-303. doi: 10.1080/15227950490952424. PMID: 16137166

Proteus syndrome.

Kloeppel R, Rothe K, Hoermann D, Schmidt F, Bennek J, Kahn T
J Comput Assist Tomogr 2002 Mar-Apr;26(2):262-5. doi: 10.1097/00004728-200203000-00017. PMID: 11884784

Retroperitoneal liposarcoma: sonographic findings.

Ishida H, Naganuma H, Konno K, Sato M, Hamashima Y, Konno S, Watanabe S, Asanuma Y, Ishida J
Abdom Imaging 2000 Sep-Oct;25(5):554-8. doi: 10.1007/s002610000091. PMID: 10931998

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (99)

Diagnosis

Atypical Spindle Cell/Pleomorphic Lipomatous Tumor.

Qorbani A, Horvai A
Surg Pathol Clin 2024 Mar;17(1):97-104. Epub 2023 Aug 23 doi: 10.1016/j.path.2023.07.004. PMID: 38278611

Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.

Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693

The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?

Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172

Molecular updates in adipocytic neoplasms(✰).

Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767

Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.

Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045

See all (281)

Therapy

MRI radiomics-based machine learning for classification of deep-seated lipoma and atypical lipomatous tumor of the extremities.

Gitto S, Interlenghi M, Cuocolo R, Salvatore C, Giannetta V, Badalyan J, Gallazzi E, Spinelli MS, Gallazzi M, Serpi F, Messina C, Albano D, Annovazzi A, Anelli V, Baldi J, Aliprandi A, Armiraglio E, Parafioriti A, Daolio PA, Luzzati A, Biagini R, Castiglioni I, Sconfienza LM
Radiol Med 2023 Aug;128(8):989-998. Epub 2023 Jun 19 doi: 10.1007/s11547-023-01657-y. PMID: 37335422 Free PMC Article

Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.

Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512

Recent Advancement in Atypical Lipomatous Tumor Research.

Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189 Free PMC Article

Managing Liposarcomas: Cutting Through the Fat.

Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163

Interdisciplinary management of congenital infiltrating lipomatosis.

Tracy JC, Klement GL, Scott AR
Int J Pediatr Otorhinolaryngol 2013 Dec;77(12):2071-4. Epub 2013 Aug 22 doi: 10.1016/j.ijporl.2013.08.008. PMID: 24035641

See all (8)

Prognosis

The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?

Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172

Molecular updates in adipocytic neoplasms(✰).

Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767

Lipomatous tumors of the breast: A contemporary review.

Rowe JJ, Cheah AL, Calhoun BC
Semin Diagn Pathol 2017 Sep;34(5):453-461. Epub 2017 May 29 doi: 10.1053/j.semdp.2017.05.008. PMID: 28662999

The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.

Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (89)

Clinical prediction guides

Prognostic value of clinical and MRI features in the screening of lipomatous lesions.

Scherrer Y, Laux CJ, Götschi T, Rosskopf AB, Müller DA
Surg Oncol 2023 Oct;50:101984. Epub 2023 Aug 18 doi: 10.1016/j.suronc.2023.101984. PMID: 37619507

Liposarcoma Preoperatively Diagnosed as Lipoma: 10-Year Experience at a Single Institution.

Sato D, Suga H, Takushima A
Dermatol Surg 2018 Aug;44(8):1065-1069. doi: 10.1097/DSS.0000000000001533. PMID: 29659409

Lipomatous tumors of the breast: A contemporary review.

Rowe JJ, Cheah AL, Calhoun BC
Semin Diagn Pathol 2017 Sep;34(5):453-461. Epub 2017 May 29 doi: 10.1053/j.semdp.2017.05.008. PMID: 28662999

The histological variants of liposarcoma: predictive MRI findings with prognostic implications, management, follow-up, and differential diagnosis.

Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Intrathoracic omental herniation through the esophageal hiatus: a case report.

Kubota K, Ohara S, Yoshida S, Nonami Y, Takahashi T
Radiat Med 2001 Nov-Dec;19(6):307-11. PMID: 11837582

See all (85)

Recent systematic reviews

Radiomics-based approaches outperform visual analysis for differentiating lipoma from atypical lipomatous tumors: a review.

Haidey J, Low G, Wilson MP
Skeletal Radiol 2023 Jun;52(6):1089-1100. Epub 2022 Nov 16 doi: 10.1007/s00256-022-04232-0. PMID: 36385583

Atypical Lipomatous Tumors: Does Our Inconsistent Terminology Have Patient Repercussions? Results of a Meta-Analysis.

Fourman MS, van Eck CF, Weiss KR, Goodman MA, McGough RL
Am J Clin Oncol 2019 May;42(5):487-492. doi: 10.1097/COC.0000000000000540. PMID: 30932920

Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.

Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714

Neurofibroma involving obturator nerve mimicking an adnexal mass: a rare case report and PRISMA-driven systematic review.

Chao WT, Liu CH, Chen YJ, Wu HH, Chuang CM, Wang PH
J Ovarian Res 2018 Feb 9;11(1):14. doi: 10.1186/s13048-018-0386-z. PMID: 29426349 Free PMC Article

See all (4)

MedGen

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Lipomatous tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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