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Liver Neoplasms, Experimental

MedGen UID:
44184
•Concept ID:
C0023904
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Liver Neoplasm; Experimental Liver Neoplasms; Liver Neoplasm, Experimental; Neoplasms, Experimental Liver

Definition

Experimentally induced tumors of the LIVER. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Neoplasms, Experimental

Professional guidelines

PubMed

Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Recent clinical studies

Etiology

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W
Nat Med 2021 Jan;27(1):152-164. Epub 2021 Jan 4 doi: 10.1038/s41591-020-1131-x. PMID: 33398162Free PMC Article
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
Methyl group deficiency in hepatocarcinogenesis.
Poirier LA
Drug Metab Rev 1994;26(1-2):185-99. doi: 10.3109/03602539409029790. PMID: 8082564
Chlordane and heptachlor.
IARC Monogr Eval Carcinog Risks Hum 1991;53:115-75. PMID: 1842578Free PMC Article
Hepatocarcinogenesis.
Lau JY, Lai CL
Trop Gastroenterol 1990 Jan-Mar;11(1):9-24. PMID: 2162576

Diagnosis

Nanoliposomal Ratiometric Fluorescent Probe toward ONOO(-) Flux.
Zhang J, Kan J, Sun Y, Won M, Kim JH, Zhang W, Zhou J, Qian Z, Kim JS
ACS Appl Bio Mater 2021 Mar 15;4(3):2080-2088. Epub 2020 Nov 6 doi: 10.1021/acsabm.0c01178. PMID: 35014335
Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Loong JH, Wong TL, Tong M, Sharma R, Zhou L, Ng KY, Yu HJ, Li CH, Man K, Lo CM, Guan XY, Lee TK, Yun JP, Ma SK
J Clin Invest 2021 Jun 1;131(11) doi: 10.1172/JCI143377. PMID: 33878034Free PMC Article
Integrin α(v)β(3) Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy.
Khatik R, Wang Z, Zhi D, Kiran S, Dwivedi P, Liang G, Qiu B, Yang Q
ACS Appl Mater Interfaces 2020 Jan 8;12(1):163-176. Epub 2019 Dec 19 doi: 10.1021/acsami.9b16648. PMID: 31805767
The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma.
Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, Li BS, Yang SM
Cancer Lett 2015 May 1;360(2):119-24. Epub 2015 Feb 23 doi: 10.1016/j.canlet.2015.02.035. PMID: 25721084
Status of liposomes as MR contrast agents.
Unger EC, Shen DK, Fritz TA
J Magn Reson Imaging 1993 Jan-Feb;3(1):195-8. doi: 10.1002/jmri.1880030132. PMID: 8428087

Therapy

Oxidative Polymerization in Living Cells.
Dai Y, Li T, Zhang Z, Tan Y, Pan S, Zhang L, Xu H
J Am Chem Soc 2021 Jul 21;143(28):10709-10717. Epub 2021 Jun 23 doi: 10.1021/jacs.1c04821. PMID: 34161724
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, Lieshout R, Verstegen MMA, Ma B, Su J, Yang Q, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W
Cell Mol Gastroenterol Hepatol 2021;11(2):407-431. Epub 2020 Sep 12 doi: 10.1016/j.jcmgh.2020.09.003. PMID: 32932015Free PMC Article
Systemic therapy in hepatocellular carcinoma.
Wrzesinski SH, Taddei TH, Strazzabosco M
Clin Liver Dis 2011 May;15(2):423-41, vii-x. doi: 10.1016/j.cld.2011.03.002. PMID: 21689622Free PMC Article
Chlordane and heptachlor.
IARC Monogr Eval Carcinog Risks Hum 1991;53:115-75. PMID: 1842578Free PMC Article
Comparative toxicology of chlordecone (Kepone) in humans and experimental animals.
Guzelian PS
Annu Rev Pharmacol Toxicol 1982;22:89-113. doi: 10.1146/annurev.pa.22.040182.000513. PMID: 6177278

Prognosis

Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Loong JH, Wong TL, Tong M, Sharma R, Zhou L, Ng KY, Yu HJ, Li CH, Man K, Lo CM, Guan XY, Lee TK, Yun JP, Ma SK
J Clin Invest 2021 Jun 1;131(11) doi: 10.1172/JCI143377. PMID: 33878034Free PMC Article
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JHM, Cheung YS, Lai PBS, Yu DY, Wang Q, Wong GLH, Chan AM, Yip KY, To KF, Cheng ASL
Nucleic Acids Res 2018 Sep 28;46(17):8832-8847. doi: 10.1093/nar/gky589. PMID: 29992318Free PMC Article
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma.
Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, Li BS, Yang SM
Cancer Lett 2015 May 1;360(2):119-24. Epub 2015 Feb 23 doi: 10.1016/j.canlet.2015.02.035. PMID: 25721084
Hepatocarcinogenesis.
Lau JY, Lai CL
Trop Gastroenterol 1990 Jan-Mar;11(1):9-24. PMID: 2162576

Clinical prediction guides

Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.
Perkons NR, Johnson O, Pilla G, Profka E, Mercadante M, Ackerman D, Gade TPF
Clin Cancer Res 2020 Sep 1;26(17):4581-4589. Epub 2020 Jun 4 doi: 10.1158/1078-0432.CCR-20-0826. PMID: 32499234Free PMC Article
Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia.
Su X, Li L, Sun H, Zhang F, Li C, Li F, Wang H, Li B, Chen R, Kang J
Bioorg Chem 2019 Jun;87:867-875. Epub 2018 Dec 3 doi: 10.1016/j.bioorg.2018.11.055. PMID: 30528930
The emergence of long non-coding RNAs in the tumorigenesis of hepatocellular carcinoma.
Yang X, Xie X, Xiao YF, Xie R, Hu CJ, Tang B, Li BS, Yang SM
Cancer Lett 2015 May 1;360(2):119-24. Epub 2015 Feb 23 doi: 10.1016/j.canlet.2015.02.035. PMID: 25721084
Chemoprevention of breast cancer by tamoxifen: risks and opportunities.
Smith LL, Brown K, Carthew P, Lim CK, Martin EA, Styles J, White IN
Crit Rev Toxicol 2000 Sep;30(5):571-94. doi: 10.1080/10408440008951120. PMID: 11055836
Hepatitis C virus and hepatocellular carcinoma.
Sangiovanni A, Covini G, Rumi MG, Marcelli R, Colombo M
Arch Virol Suppl 1992;4:70-5. doi: 10.1007/978-3-7091-5633-9_15. PMID: 1333332

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