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Experimental Tumor

MedGen UID:
10216
Concept ID:
C0027659
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Neoplasm; Experimental Neoplasms; Neoplasm, Experimental; Neoplasms, Experimental

Definition

Laboratory tumor models used to study tumor development and treatment. [from NCI]

Professional guidelines

PubMed

Wolf SP, Wen FT, Schreiber H
Curr Opin Immunol 2022 Feb;74:25-31. Epub 2021 Oct 4 doi: 10.1016/j.coi.2021.09.002. PMID: 34619458Free PMC Article
Tisato V, Voltan R, Gonelli A, Secchiero P, Zauli G
J Hematol Oncol 2017 Jul 3;10(1):133. doi: 10.1186/s13045-017-0500-5. PMID: 28673313Free PMC Article
Evers BM, Parekh D, Townsend CM Jr, Thompson JC
Ann Surg 1991 Mar;213(3):190-8. doi: 10.1097/00000658-199103000-00002. PMID: 1671812Free PMC Article

Recent clinical studies

Etiology

Reissig TM, Ladigan-Badura S, Steinberg A, Maghnouj A, Li T, Verdoodt B, Liffers ST, Pohl M, Wolters H, Teschendorf C, Viebahn R, Admard J, Casadei N, Tannapfel A, Schmiegel W, Hahn SA, Vangala DB
Mol Oncol 2023 Nov;17(11):2396-2414. Epub 2023 Sep 3 doi: 10.1002/1878-0261.13510. PMID: 37604687Free PMC Article
Hassel JC, Berking C, Forschner A, Gebhardt C, Heinzerling L, Meier F, Ochsenreither S, Siveke J, Hauschild A, Schadendorf D
Eur J Cancer 2023 Sep;191:112986. Epub 2023 Jul 11 doi: 10.1016/j.ejca.2023.112986. PMID: 37595494
Hamacher R, Lanzafame H, Mavroeidi IA, Pabst KM, Kessler L, Cheung PF, Bauer S, Herrmann K, Schildhaus HU, Siveke JT, Fendler WP
PET Clin 2023 Jul;18(3):361-367. Epub 2023 Mar 28 doi: 10.1016/j.cpet.2023.02.008. PMID: 36997366
Lazaridis L, Schmidt T, Oster C, Blau T, Pierscianek D, Siveke JT, Bauer S, Schildhaus HU, Sure U, Keyvani K, Kleinschnitz C, Stuschke M, Herrmann K, Deuschl C, Scheffler B, Kebir S, Glas M
J Cancer Res Clin Oncol 2023 Jul;149(7):3513-3526. Epub 2022 Aug 12 doi: 10.1007/s00432-022-04050-w. PMID: 35953681Free PMC Article
Gad-el-Mawla N
Ann Oncol 1992 Aug;3 Suppl 3:21-3. doi: 10.1093/annonc/3.suppl_3.s21. PMID: 1390313

Diagnosis

Schuler M, Hense J, Darwiche K, Michels S, Hautzel H, Kobe C, Lueong S, Metzenmacher M, Herold T, Zaun G, Laue K, Drzezga A, Theegarten D, Nensa F, Wolf J, Herrmann K, Wiesweg M
J Nucl Med 2024 Jun 3;65(6):851-855. doi: 10.2967/jnumed.123.266979. PMID: 38575188
Erice O, Narayanan S, Feliu I, Entrialgo-Cadierno R, Malinova A, Vicentini C, Guruceaga E, Delfino P, Trajkovic-Arsic M, Moreno H, Valencia K, Blanco E, Macaya I, Öhlund D, Khatri P, Lecanda F, Scarpa A, Siveke JT, Corbo V, Ponz-Sarvise M, Vicent S
Clin Cancer Res 2023 Mar 14;29(6):1137-1154. doi: 10.1158/1078-0432.CCR-22-0794. PMID: 36607777
Lazaridis L, Schmidt T, Oster C, Blau T, Pierscianek D, Siveke JT, Bauer S, Schildhaus HU, Sure U, Keyvani K, Kleinschnitz C, Stuschke M, Herrmann K, Deuschl C, Scheffler B, Kebir S, Glas M
J Cancer Res Clin Oncol 2023 Jul;149(7):3513-3526. Epub 2022 Aug 12 doi: 10.1007/s00432-022-04050-w. PMID: 35953681Free PMC Article
Horak P, Heining C, Kreutzfeldt S, Hutter B, Mock A, Hüllein J, Fröhlich M, Uhrig S, Jahn A, Rump A, Gieldon L, Möhrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DB, Allgäuer M, Ruhnke L, Laßmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfütze K, Geörg C, Meißburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff K, von Kalle C, Klink B, Brors B, Stenzinger A, Schröck E, Hübschmann D, Weichert W, Glimm H, Fröhling S
Cancer Discov 2021 Nov;11(11):2780-2795. Epub 2021 Jun 10 doi: 10.1158/2159-8290.CD-21-0126. PMID: 34112699
Rüttinger D, Hatz RA, Jauch KW, Fox BA
Surg Oncol Clin N Am 2007 Oct;16(4):901-18, x. doi: 10.1016/j.soc.2007.07.004. PMID: 18022551

Therapy

Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N
Nature 2023 Mar;615(7950):168-174. Epub 2023 Feb 22 doi: 10.1038/s41586-023-05728-y. PMID: 36813961Free PMC Article
Li Y, Zhang H, Chen C, Qiao K, Li Z, Han J, Han X, Li K, Lai K, Liu N, Li A, Xiao N, Zhang Y, Zhao X, Gao W, Zhang Y, Liu H, Sun T
Adv Mater 2022 May;34(19):e2108476. Epub 2022 Apr 3 doi: 10.1002/adma.202108476. PMID: 35267211
Horak P, Heining C, Kreutzfeldt S, Hutter B, Mock A, Hüllein J, Fröhlich M, Uhrig S, Jahn A, Rump A, Gieldon L, Möhrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DB, Allgäuer M, Ruhnke L, Laßmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfütze K, Geörg C, Meißburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff K, von Kalle C, Klink B, Brors B, Stenzinger A, Schröck E, Hübschmann D, Weichert W, Glimm H, Fröhling S
Cancer Discov 2021 Nov;11(11):2780-2795. Epub 2021 Jun 10 doi: 10.1158/2159-8290.CD-21-0126. PMID: 34112699
Winter H, Fox BA, Rüttinger D
Methods Mol Biol 2014;1139:555-64. doi: 10.1007/978-1-4939-0345-0_40. PMID: 24619704
Vucenik I, Shamsuddin AM
Nutr Cancer 2006;55(2):109-25. doi: 10.1207/s15327914nc5502_1. PMID: 17044765

Prognosis

Schuler M, Hense J, Darwiche K, Michels S, Hautzel H, Kobe C, Lueong S, Metzenmacher M, Herold T, Zaun G, Laue K, Drzezga A, Theegarten D, Nensa F, Wolf J, Herrmann K, Wiesweg M
J Nucl Med 2024 Jun 3;65(6):851-855. doi: 10.2967/jnumed.123.266979. PMID: 38575188
Hamacher R, Lanzafame H, Mavroeidi IA, Pabst KM, Kessler L, Cheung PF, Bauer S, Herrmann K, Schildhaus HU, Siveke JT, Fendler WP
PET Clin 2023 Jul;18(3):361-367. Epub 2023 Mar 28 doi: 10.1016/j.cpet.2023.02.008. PMID: 36997366
Erice O, Narayanan S, Feliu I, Entrialgo-Cadierno R, Malinova A, Vicentini C, Guruceaga E, Delfino P, Trajkovic-Arsic M, Moreno H, Valencia K, Blanco E, Macaya I, Öhlund D, Khatri P, Lecanda F, Scarpa A, Siveke JT, Corbo V, Ponz-Sarvise M, Vicent S
Clin Cancer Res 2023 Mar 14;29(6):1137-1154. doi: 10.1158/1078-0432.CCR-22-0794. PMID: 36607777
Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832Free PMC Article
Winter H, Fox BA, Rüttinger D
Methods Mol Biol 2014;1139:555-64. doi: 10.1007/978-1-4939-0345-0_40. PMID: 24619704

Clinical prediction guides

Hamacher R, Lanzafame H, Mavroeidi IA, Pabst KM, Kessler L, Cheung PF, Bauer S, Herrmann K, Schildhaus HU, Siveke JT, Fendler WP
PET Clin 2023 Jul;18(3):361-367. Epub 2023 Mar 28 doi: 10.1016/j.cpet.2023.02.008. PMID: 36997366
Tintelnot J, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S, Gagliani N
Nature 2023 Mar;615(7950):168-174. Epub 2023 Feb 22 doi: 10.1038/s41586-023-05728-y. PMID: 36813961Free PMC Article
Li Y, Zhang H, Chen C, Qiao K, Li Z, Han J, Han X, Li K, Lai K, Liu N, Li A, Xiao N, Zhang Y, Zhao X, Gao W, Zhang Y, Liu H, Sun T
Adv Mater 2022 May;34(19):e2108476. Epub 2022 Apr 3 doi: 10.1002/adma.202108476. PMID: 35267211
Horak P, Heining C, Kreutzfeldt S, Hutter B, Mock A, Hüllein J, Fröhlich M, Uhrig S, Jahn A, Rump A, Gieldon L, Möhrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DB, Allgäuer M, Ruhnke L, Laßmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfütze K, Geörg C, Meißburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff K, von Kalle C, Klink B, Brors B, Stenzinger A, Schröck E, Hübschmann D, Weichert W, Glimm H, Fröhling S
Cancer Discov 2021 Nov;11(11):2780-2795. Epub 2021 Jun 10 doi: 10.1158/2159-8290.CD-21-0126. PMID: 34112699
Wischhusen J, Melero I, Fridman WH
Front Immunol 2020;11:951. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00951. PMID: 32508832Free PMC Article

Recent systematic reviews

Mesas C, Chico MA, Doello K, Lara P, Moreno J, Melguizo C, Perazzoli G, Prados J
Int J Mol Sci 2024 Jan 9;25(2) doi: 10.3390/ijms25020837. PMID: 38255911Free PMC Article

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