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expressive language disorder

MedGen UID:
452300
•Concept ID:
C0236826
•
Mental or Behavioral Dysfunction
Synonyms: Developmental expressive language disorder; developmental expressive language disorder; Expressive Language Disorder
SNOMED CT: Developmental expressive language disorder (268734000)
 
Monarch Initiative: MONDO:0001276

Definition

A disorder characterized by an impairment in the development of an individual''s expressive language which is in contrast to his/her nonverbal intellect and receptive language development. The impairment may be acquired (i.e., due to a brain lesion or head trauma) or developmental (i.e., no known neurological insult). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVexpressive language disorder

Professional guidelines

PubMed

Co-morbidity and treatment of attention deficit hyperactivity disorder in Saudi Arabia.
Al-Haidar FA
East Mediterr Health J 2003 Sep-Nov;9(5-6):988-95. PMID: 16450529
Evaluation and management of the child with speech delay.
Leung AK, Kao CP
Am Fam Physician 1999 Jun;59(11):3121-8, 3135. PMID: 10392594

Recent clinical studies

Etiology

Language phenotypes in children with autism spectrum disorder, expressive language disorder, and typical language development.
Doghadze I, Gagoshidze T
Appl Neuropsychol Child 2025 Jan-Mar;14(1):12-22. Epub 2023 Jun 9 doi: 10.1080/21622965.2023.2221359. PMID: 37293942
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis.
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D, Rehm J
Lancet 2016 Mar 5;387(10022):978-987. Epub 2016 Jan 6 doi: 10.1016/S0140-6736(15)01345-8. PMID: 26777270
Sensorimotor function in preschool-aged children with expressive language disorder.
Müürsepp I, Aibast H, Gapeyeva H, Pääsuke M
Res Dev Disabil 2014 Jun;35(6):1237-43. Epub 2014 Mar 28 doi: 10.1016/j.ridd.2014.03.007. PMID: 24685939
Language growth in children with expressive language delay.
Fischel JE, Whitehurst GJ, Caulfield MB, DeBaryshe B
Pediatrics 1989 Feb;83(2):218-27. PMID: 2913552
Behavioral correlates of developmental expressive language disorder.
Caulfield MB, Fischel JE, DeBaryshe BD, Whitehurst GJ
J Abnorm Child Psychol 1989 Apr;17(2):187-201. doi: 10.1007/BF00913793. PMID: 2745899

Diagnosis

Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis.
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D, Rehm J
Lancet 2016 Mar 5;387(10022):978-987. Epub 2016 Jan 6 doi: 10.1016/S0140-6736(15)01345-8. PMID: 26777270
Speech and language delay in children.
McLaughlin MR
Am Fam Physician 2011 May 15;83(10):1183-8. PMID: 21568252
Is expressive language disorder an accurate diagnostic category?
Leonard LB
Am J Speech Lang Pathol 2009 May;18(2):115-23. Epub 2008 Nov 24 doi: 10.1044/1058-0360(2008/08-0064). PMID: 19029534Free PMC Article
Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder.
O'Malley KD, Nanson J
Can J Psychiatry 2002 May;47(4):349-54. doi: 10.1177/070674370204700405. PMID: 12025433
Evaluation and management of the child with speech delay.
Leung AK, Kao CP
Am Fam Physician 1999 Jun;59(11):3121-8, 3135. PMID: 10392594

Therapy

Adaptation, validity, and reliability of the Preschool Language Scale-Fifth Edition (PLS-5) in the Turkish context: The Turkish Preschool Language Scale-5 (TPLS-5).
Sahli AS, Belgin E
Int J Pediatr Otorhinolaryngol 2017 Jul;98:143-149. Epub 2017 May 10 doi: 10.1016/j.ijporl.2017.05.003. PMID: 28583491
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis.
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D, Rehm J
Lancet 2016 Mar 5;387(10022):978-987. Epub 2016 Jan 6 doi: 10.1016/S0140-6736(15)01345-8. PMID: 26777270
Clinical and biochemical outcome after hydroxocobalamin dose escalation in a series of patients with cobalamin C deficiency.
Matos IV, Castejón E, Meavilla S, O'Callaghan M, Garcia-Villoria J, López-Sala A, Ribes A, Artuch R, Garcia-Cazorla A
Mol Genet Metab 2013 Aug;109(4):360-5. Epub 2013 May 22 doi: 10.1016/j.ymgme.2013.05.007. PMID: 23746552
Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature.
Fandiño M, Connolly M, Usher L, Palm S, Kozak FK
Int J Pediatr Otorhinolaryngol 2011 Jan;75(1):33-8. Epub 2010 Nov 12 doi: 10.1016/j.ijporl.2010.10.001. PMID: 21074868
Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder.
Hamrin V, Bailey K
J Child Adolesc Psychopharmacol 2001 Fall;11(3):301-9. doi: 10.1089/10445460152595630. PMID: 11642481

Prognosis

X-linked myotubular myopathy: a clinical report and a review of the mild phenotype.
Barreto-Mota R, Figueirinha J, Quental R, Fonseca J, Melo C, Sampaio M, Sousa R
Rev Neurol 2023 Apr 1;76(7):243-246. doi: 10.33588/rn.7607.2021447. PMID: 36973888Free PMC Article
Speech and language delay in children.
McLaughlin MR
Am Fam Physician 2011 May 15;83(10):1183-8. PMID: 21568252
Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature.
Fandiño M, Connolly M, Usher L, Palm S, Kozak FK
Int J Pediatr Otorhinolaryngol 2011 Jan;75(1):33-8. Epub 2010 Nov 12 doi: 10.1016/j.ijporl.2010.10.001. PMID: 21074868
The influence of premorbid language skills and behavior on language recovery in children with verbal auditory agnosia.
Klein SK, Tuchman RF, Rapin I
J Child Neurol 2000 Jan;15(1):36-43. doi: 10.1177/088307380001500109. PMID: 10641609
Language growth in children with expressive language delay.
Fischel JE, Whitehurst GJ, Caulfield MB, DeBaryshe B
Pediatrics 1989 Feb;83(2):218-27. PMID: 2913552

Clinical prediction guides

Language phenotypes in children with autism spectrum disorder, expressive language disorder, and typical language development.
Doghadze I, Gagoshidze T
Appl Neuropsychol Child 2025 Jan-Mar;14(1):12-22. Epub 2023 Jun 9 doi: 10.1080/21622965.2023.2221359. PMID: 37293942
X-linked myotubular myopathy: a clinical report and a review of the mild phenotype.
Barreto-Mota R, Figueirinha J, Quental R, Fonseca J, Melo C, Sampaio M, Sousa R
Rev Neurol 2023 Apr 1;76(7):243-246. doi: 10.33588/rn.7607.2021447. PMID: 36973888Free PMC Article
Sensorimotor function in preschool-aged children with expressive language disorder.
Müürsepp I, Aibast H, Gapeyeva H, Pääsuke M
Res Dev Disabil 2014 Jun;35(6):1237-43. Epub 2014 Mar 28 doi: 10.1016/j.ridd.2014.03.007. PMID: 24685939
Language growth in children with expressive language delay.
Fischel JE, Whitehurst GJ, Caulfield MB, DeBaryshe B
Pediatrics 1989 Feb;83(2):218-27. PMID: 2913552
Behavioral correlates of developmental expressive language disorder.
Caulfield MB, Fischel JE, DeBaryshe BD, Whitehurst GJ
J Abnorm Child Psychol 1989 Apr;17(2):187-201. doi: 10.1007/BF00913793. PMID: 2745899

Recent systematic reviews

Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis.
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D, Rehm J
Lancet 2016 Mar 5;387(10022):978-987. Epub 2016 Jan 6 doi: 10.1016/S0140-6736(15)01345-8. PMID: 26777270

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