U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Digestive System Neuroendocrine Tumor G2

MedGen UID:
474250
Concept ID:
C3272617
Neoplastic Process
Synonyms: Gastrointestinal NET G2; Gastrointestinal Neuroendocrine Tumor G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the digestive system. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Professional guidelines

PubMed

Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Kasajima A, Klöppel G
Pathologie (Heidelb) 2024 Nov;45(Suppl 1):51-55. Epub 2024 Oct 2 doi: 10.1007/s00292-024-01360-3. PMID: 39356330
Parisi A, Delaunay B, Pinterpe G, Hollebecque A, Blanc JF, Bouattour M, Assenat E, Ben Abdelghani M, Sarabi M, Niger M, Vivaldi C, Mandalà M, Palloni A, Bensi M, Garattini SK, Tougeron D, Combe P, Salati M, Rimini M, Cella CA, Tucci M, Diana A, Mori E, Longarini R, Artru P, Roth G, Evesque L, Vienne A, Turpin A, Hiret S, Bourgeois V, Herve C, Paulon R, Stacoffe M, Malka D, Neuzillet C, Edeline J, Lievre A, Guimbaud R, Chapda MCP, Rimassa L, Giampieri R, Valle J, Berardi R, Fares N
Eur J Cancer 2024 Mar;200:113587. Epub 2024 Feb 6 doi: 10.1016/j.ejca.2024.113587. PMID: 38340384
Hamada Y, Tanaka K, Mukai K, Baba Y, Kobayashi M, Tominaga S, Kawabata H, Sawai S, Kaneko M, Sugimoto S, Inoue H, Mimuro M, Tamaru S, Nakagawa H
Dig Dis Sci 2023 Jul;68(7):3148-3157. Epub 2023 Apr 6 doi: 10.1007/s10620-023-07914-4. PMID: 37024740
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544
Ezziddin S, Opitz M, Attassi M, Biermann K, Sabet A, Guhlke S, Brockmann H, Willinek W, Wardelmann E, Biersack HJ, Ahmadzadehfar H
Eur J Nucl Med Mol Imaging 2011 Mar;38(3):459-66. Epub 2010 Sep 18 doi: 10.1007/s00259-010-1610-2. PMID: 20852858

Diagnosis

Kasajima A, Klöppel G
Pathologie (Heidelb) 2024 Nov;45(Suppl 1):51-55. Epub 2024 Oct 2 doi: 10.1007/s00292-024-01360-3. PMID: 39356330
Parisi A, Delaunay B, Pinterpe G, Hollebecque A, Blanc JF, Bouattour M, Assenat E, Ben Abdelghani M, Sarabi M, Niger M, Vivaldi C, Mandalà M, Palloni A, Bensi M, Garattini SK, Tougeron D, Combe P, Salati M, Rimini M, Cella CA, Tucci M, Diana A, Mori E, Longarini R, Artru P, Roth G, Evesque L, Vienne A, Turpin A, Hiret S, Bourgeois V, Herve C, Paulon R, Stacoffe M, Malka D, Neuzillet C, Edeline J, Lievre A, Guimbaud R, Chapda MCP, Rimassa L, Giampieri R, Valle J, Berardi R, Fares N
Eur J Cancer 2024 Mar;200:113587. Epub 2024 Feb 6 doi: 10.1016/j.ejca.2024.113587. PMID: 38340384
Sun H, Zhang S, Liu K, Zhou J, Wang X, Shen T, Wang X
Acta Radiol 2019 Nov;60(11):1394-1404. Epub 2019 Mar 26 doi: 10.1177/0284185119840212. PMID: 30913907
Kim JY, Hong SM
Arch Pathol Lab Med 2016 May;140(5):437-48. doi: 10.5858/arpa.2015-0314-RA. PMID: 27128301
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544

Therapy

Salemi R, Vivarelli S, Ricci D, Scillato M, Santagati M, Gattuso G, Falzone L, Libra M
J Transl Med 2023 Mar 14;21(1):195. doi: 10.1186/s12967-023-04036-3. PMID: 36918929Free PMC Article
Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936
Zhang M, Zhao P, Shi X, Zhao A, Zhang L, Zhou L
BMC Endocr Disord 2017 Jul 13;17(1):39. doi: 10.1186/s12902-017-0190-6. PMID: 28705205Free PMC Article
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Ezziddin S, Opitz M, Attassi M, Biermann K, Sabet A, Guhlke S, Brockmann H, Willinek W, Wardelmann E, Biersack HJ, Ahmadzadehfar H
Eur J Nucl Med Mol Imaging 2011 Mar;38(3):459-66. Epub 2010 Sep 18 doi: 10.1007/s00259-010-1610-2. PMID: 20852858

Prognosis

Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Sun H, Zhang S, Liu K, Zhou J, Wang X, Shen T, Wang X
Acta Radiol 2019 Nov;60(11):1394-1404. Epub 2019 Mar 26 doi: 10.1177/0284185119840212. PMID: 30913907
Mafficini A, Scarpa A
Endocr Rev 2019 Apr 1;40(2):506-536. doi: 10.1210/er.2018-00160. PMID: 30657883Free PMC Article
Kim JY, Hong SM
Arch Pathol Lab Med 2016 May;140(5):437-48. doi: 10.5858/arpa.2015-0314-RA. PMID: 27128301
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544

Clinical prediction guides

Parisi A, Delaunay B, Pinterpe G, Hollebecque A, Blanc JF, Bouattour M, Assenat E, Ben Abdelghani M, Sarabi M, Niger M, Vivaldi C, Mandalà M, Palloni A, Bensi M, Garattini SK, Tougeron D, Combe P, Salati M, Rimini M, Cella CA, Tucci M, Diana A, Mori E, Longarini R, Artru P, Roth G, Evesque L, Vienne A, Turpin A, Hiret S, Bourgeois V, Herve C, Paulon R, Stacoffe M, Malka D, Neuzillet C, Edeline J, Lievre A, Guimbaud R, Chapda MCP, Rimassa L, Giampieri R, Valle J, Berardi R, Fares N
Eur J Cancer 2024 Mar;200:113587. Epub 2024 Feb 6 doi: 10.1016/j.ejca.2024.113587. PMID: 38340384
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Goo JJ, Baek DH, Kim HW, Lee HS, Lee JY, Park SB, Song GA, Lee SH, Lee JH; Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
Surg Endosc 2023 Jul;37(7):5196-5204. Epub 2023 Mar 22 doi: 10.1007/s00464-023-09999-4. PMID: 36947224
Sun H, Zhang S, Liu K, Zhou J, Wang X, Shen T, Wang X
Acta Radiol 2019 Nov;60(11):1394-1404. Epub 2019 Mar 26 doi: 10.1177/0284185119840212. PMID: 30913907
Ezziddin S, Opitz M, Attassi M, Biermann K, Sabet A, Guhlke S, Brockmann H, Willinek W, Wardelmann E, Biersack HJ, Ahmadzadehfar H
Eur J Nucl Med Mol Imaging 2011 Mar;38(3):459-66. Epub 2010 Sep 18 doi: 10.1007/s00259-010-1610-2. PMID: 20852858

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...